Zobrazeno 91 - 100
of 261
pro vyhledávání: '"Yong J. Lee"'
Publikováno v:
Biochemical pharmacology. 88(2)
Recent studies indicate that a complex relationship exists between autophagy and apoptosis. In this study we investigated a regulatory relationship between autophagy and apoptosis in colorectal cancer cells utilizing molecular and biochemical approac
Autor:
Mi Young Han, Sun Hee Baek, Eun Mi Park, Young Mee Park, Jin Na Min, Yong J. Lee, Yun Sil Lee
Publikováno v:
Journal of Cellular Physiology. 183:100-107
Expression of heat shock proteins (HSPs) has been shown to protect mammalian cells exposed to a variety of stress stimuli. Among various HSPs, small HSPs from diverse species were shown to protect cells against oxidative stress. Here, we show that th
Autor:
Sandra Galoforo, Yong J. Lee, Lisa A. Ridnour, Julia E. Sim, Henry Jay Forman, Peter M. Corry, Douglas R. Spitz, Jinah Choi
Publikováno v:
Free Radical Biology and Medicine. 28:575-584
Signal transduction pathway involved in glucose deprivation-induced oxidative stress were investigated in human breast carcinoma cells (MCF-7/ADR). In MCF-7/ADR, glucose deprivation-induced prolonged activation of c-Jun N-terminal kinase (JNK1) as we
Publikováno v:
International Journal of Developmental Neuroscience. 17:447-461
To investigate the hypothesis that protein kinase Calpha (PKCalpha) is functional glial tumor cell invasion, stable PKCalpha sense and antisense transfected U-87 cell lines were established and PKCalpha expression characterized by Western blot and PK
Publikováno v:
International Journal of Cancer. 82:293-297
Prostate tumor cells (PC-3) were transduced with defective, recombinant adenovirus containing a fusion gene encoding the Escherichia coli cytosine deaminase and herpes simplex virus type-1 thymidine kinase under the control of a cytomegalovirus promo
Autor:
Yong J. Lee, Peter M. Corry
Publikováno v:
Molecular and Cellular Biochemistry. 202:1-8
Although the synthesis of angiogenic factors in hypoxic regions of solid tumors is recognized as one of the critical steps in tumor growth and metastasis, the signal transduction pathway involved in hypoxic induction of basic fibroblast growth factor
Autor:
Peter M. Corry, Yong J. Lee
Publikováno v:
Journal of Biological Chemistry. 273:29857-29863
In previous reports we demonstrated that glucose deprivation induces metabolic oxidative stress in drug-resistant human breast carcinoma MCF-7/ADR cells (Lee, Y. J., Galoforo, S. S., Berns, c. M., Chen, J. C., Davis, B. H., Swim, J. E., Corry, P. M.,
Autor:
Sandra Galoforo, Yong J. Lee, Robert V. Blackburn, M B S Christine Berns, Peter M. Corry, Nalini M. Motwani
Publikováno v:
Cancer. 82:1137-1145
BACKGROUND High grade gliomas represent very aggressive and lethal forms of human cancer, which often exhibit recurrence after surgical intervention and resistance to conventional chemotherapeutic and radiologic treatment. The clinically approved ant
Publikováno v:
Journal of Cellular Physiology. 174:27-34
Previously we and others have demonstrated that oxidative stress involving generation of reactive oxygen species (ROS) is responsible for the cytotoxic action of TNF alpha. Protective effect of small heat shock proteins (HSP) against diverse oxidativ
Autor:
Christine M. Berns, Peter M. Corry, Donna McEachern, Sandra Galoforo, Robert V. Blackburn, Elwood P. Armour, Yong J. Lee
Publikováno v:
International Journal of Cancer. 72:871-877
We have developed a novel system for examining the possible contribution of small heat shock proteins (hsp) to tumor growth. L929 fibrosarcoma cells, which do not express significant levels of endogenous hsp25, were stably transfected with either mur