Zobrazeno 61 - 70
of 330
pro vyhledávání: '"Xin-Hua Feng"'
Autor:
Qinghua Liao, Mei Tang, Haitao Zhang, Liangyi Chen, Shuaifeng Li, Guoxuan Zhong, Jia Feng, Jianhui Zhao, Chenliang Wang, Huasong Lu, Yuan Si, Liuju Li, Xiaolei Cao, Manuel Kaulich, Li Li, Feifeng Zhu, Fangwei Wang, Tingbo Liang, Bin Zhao, Zongping Xia, Xin-Hua Feng, Haidong Li
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
The human kinome comprises 538 kinases playing essential functions by catalyzing protein phosphorylation. Annotation of subcellular distribution of the kinome greatly facilitates investigation of normal and disease mechanisms. Here, we present Kinome
Autor:
Xiaolei Cao, Xin-Hua Feng, Manuel Kaulich, Zongping Xia, Jia Feng, Jianhui Zhao, Haidong Li, Tingbo Liang, Huasong Lu, Shuaifeng Li, Feifeng Zhu, Chenliang Wang, Fangwei Wang, Bin Zhao, Mei Tang, Yuan Si, Guoxuan Zhong, Li Li, Haitao Zhang, Qinghua Liao, Liangyi Chen, Liuju Li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::483f40ec0d5856e31d16ba4d42c4821d
https://doi.org/10.7554/elife.64943.sa2
https://doi.org/10.7554/elife.64943.sa2
Autor:
Li Shen, Jian Zou, Qingzhe Wu, Shengduo Liu, Shiying Wu, Jun Qin, Songying Ouyang, Fansen Meng, Xin-Hua Feng, Fei Zhang, Xinran Li, Ruyuan Zhou, Jun Huang, Pinglong Xu, Zongping Xia, Hai Song, Qian Zhang
Publikováno v:
Nature Cell Biology. 21:1027-1040
Sensing cytosolic DNA through the cGAS–STING pathway constitutes a widespread innate immune mechanism to monitor cellular damage and microbial invasion. Evading this surveillance is crucial in tumorigenesis, but the process remains largely unexplor
Autor:
Tao Huang, Jin Jin, Xin-tao Mao, Rong-bei Liu, Yu Zhang, Jiang-yan Zhong, Xin-Hua Feng, Zhengjun Gao, Ling-jie Huang, Jian-shuai Yu, Ke-qi Fan, Yuan Zhao, Qian Cao, Fei Wang, Peng Xiao, Yiyuan Li
Publikováno v:
Journal of Clinical Investigation. 129:2856-2871
Calcineurin acts as a calcium-activated phosphatase that dephosphorylates various substrates, including members of the nuclear factor of activated T cells (NFAT) family, to trigger their nuclear translocation and transcriptional activity. However, th
Autor:
Tingbo Liang, Yulong Wang, Youli Zu, Ting Liu, Zhe Chen, Yongxian Xu, Bin Zhao, Junfang Ji, Jun Qin, Yi Li, Xia Lin, Xin-Hua Feng, Stephen P. Malkoski, Qianting Zhang, Yi Yu, Hongxing Wu, Mu Xiao, Lan Qin, Shuchen Gu, Hao Li, Hongbin Ji, Fenfang Chen, Chen Ding, Pinglong Xu, Li Shen, Yezhang Zhu
Publikováno v:
Nature Cell Biology. 21:179-189
Loss of TGF-β tumour suppressive response is a hallmark of human cancers. As a central player in TGF-β signal transduction, SMAD4 (also known as DPC4) is frequently mutated or deleted in gastrointestinal and pancreatic cancer. However, such genetic
Autor:
Jian Zou, Jianping Jin, Xin-Hua Feng, Ting Liu, Jinquan Liu, Shuchen Gu, Mingjie Zheng, Meiling Zhao, Bo Yuan
Publikováno v:
Journal of Genetics and Genomics. 45:639-650
Smads are critical intracellular signal transducers for transforming growth factor-β (TGF-β) in mammalian cells. In this study, we have identified WD repeat-containing protein 74 (WDR74) as a novel transcriptional coactivator for Smads in the canon
Autor:
Jun Qin, Yan Jessie Zhang, Qirou Wu, Xiaojian Wang, Xin-Hua Feng, Fansen Meng, Pinglong Xu, Mengqiu Wang, Liming Wu, Shengduo Liu, Xia Lin, Fei Zhang, Seema Irani, Xiao Li, Jian Zou, Tingbo Liang, Ruyuan Zhou, Hai Song, Qian Zhang
Publikováno v:
PLoS Biology
PLoS Biology, Vol 19, Iss 2, p e3001122 (2021)
PLoS Biology, Vol 19, Iss 2, p e3001122 (2021)
The Hippo-YAP pathway responds to diverse environmental cues to manage tissue homeostasis, organ regeneration, tumorigenesis, and immunity. However, how phosphatase(s) directly target Yes-associated protein (YAP) and determine its physiological activ
Autor:
Qian Zhang, Hongxin Guan, Hai Song, Jun Qin, Ailian Wang, Shasha Chen, Dan Zhang, Pinglong Xu, Qirou Wu, Tingbo Liang, Xiaojian Wang, Shengduo Liu, Junxian Wang, Songying Ouyang, Zhengfan Jiang, Jian Zou, Xin-Hua Feng
Publikováno v:
Molecular cell. 80(5)
Mitochondrial morphology shifts rapidly to manage cellular metabolism, organelle integrity, and cell fate. It remains unknown whether innate nucleic acid sensing, the central and general mechanisms of monitoring both microbial invasion and cellular d
Autor:
Xin-Hua Feng, Xinran Li
Publikováno v:
Biochemical pharmacology. 180
The Transforming Growth Factor-β (TGF-β) signaling pathway plays a versatile role in diverse physiological and disease conditions. Outcomes of TGF-β signaling are divergent, sometimes even opposite, on cellular functions and disease progression th
Autor:
Yu Jiang, Vesa Kaartinen, Gustavo J. Martinez, Kentaro Tanaka, Xin-Hua Feng, Shinya Tanaka, Qiang Tian, Xiaohu Wang, Chen Dong, Tomohiro Kurosaki, Xiaowei Yan
Publikováno v:
The Journal of Experimental Medicine
Trim33, a modulator of TGF-β signaling, mediates the proinflammatory function of Th17 cells by the promotion of IL-17 and repression of IL-10 production. These cytokine expressions are regulated through an epigenetic mechanism in cooperation with Sm