Zobrazeno 41 - 50
of 1 552
pro vyhledávání: '"Wiegering, A."'
Autor:
J. Diers, J. Wagner, P. Baum, S. Lichthardt, C. Kastner, N. Matthes, H. Matthes, C.‐T. Germer, S. Löb, A. Wiegering
Publikováno v:
BJS Open, Vol 4, Iss 2, Pp 310-319 (2020)
Background The impact of hospital volume after rectal cancer surgery is seldom investigated. This study aimed to analyse the impact of annual rectal cancer surgery cases per hospital on postoperative mortality and failure to rescue. Methods All patie
Externí odkaz:
https://doaj.org/article/577664d354b0400ea6eee5d9e2cfdd89
Autor:
Angela Tomasovic, Theresa Brand, Constanze Schanbacher, Sofia Kramer, Martin W. Hümmert, Patricio Godoy, Wolfgang Schmidt-Heck, Peter Nordbeck, Jonas Ludwig, Susanne Homann, Armin Wiegering, Timur Shaykhutdinov, Christoph Kratz, Ruth Knüchel, Hans-Konrad Müller-Hermelink, Andreas Rosenwald, Norbert Frey, Jutta Eichler, Dobromir Dobrev, Ali El-Armouche, Jan G. Hengstler, Oliver J. Müller, Karsten Hinrichs, Friederike Cuello, Alma Zernecke, Kristina Lorenz
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Drugs targeting dysregulated ERK1/2 signaling can cause severe cardiac side effects, precluding their wide therapeutic application. Here, a new and cardio-safe targeting strategy is presented that interferes with ERK dimerization to prevent pathologi
Externí odkaz:
https://doaj.org/article/422072e270cd48449067eb1413f577cb
Autor:
Sven Lichthardt, Johanna Wagner, Stefan Löb, Niels Matthes, Caroline Kastner, Friedrich Anger, Christoph-Thomas Germer, Armin Wiegering
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-8 (2020)
Abstract Background Preoperative chemoradiotherapy is the recommended standard of care for patients with local advanced rectal cancer. However, it remains unclear, whether a prolonged time interval to surgery results in an increased perioperative mor
Externí odkaz:
https://doaj.org/article/05833cea802b4f58a4847c40d8cf5a06
Autor:
Wagner Johanna, Lock Johan F., Kastner Carolin, Klein Ingo, Krajinovic Katica, Löb Stefan, Germer Christoph-Thomas, Wiegering Armin
Publikováno v:
Innovative Surgical Science, Vol 4, Iss 4, Pp 144-151 (2019)
About 10% of patients taking a chronic, oral anticoagulant therapy require an invasive procedure that can be associated with an increased risk for peri-interventional or perioperative bleeding. Depending on the risk for thromboembolism and the risk f
Externí odkaz:
https://doaj.org/article/bf6a16bc0d5b48a5a6dfd89819c3fc33
Targeting bromodomain-containing protein 4 (BRD4) inhibits MYC expression in colorectal cancer cells
Autor:
C. Otto, S. Schmidt, C. Kastner, S. Denk, J. Kettler, N. Müller, C.T. Germer, E. Wolf, P. Gallant, A. Wiegering
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 21, Iss 11, Pp 1110-1120 (2019)
The transcriptional regulator BRD4 has been shown to be important for the expression of several oncogenes including MYC. Inhibiting of BRD4 has broad antiproliferative activity in different cancer cell types. The small molecule JQ1 blocks the interac
Externí odkaz:
https://doaj.org/article/d3ad9943a1bc4db391441e2d19b014f5
Autor:
J. Diers, J. Wagner, P. Baum, S. Lichthardt, C. Kastner, N. Matthes, S. Löb, H. Matthes, C.‐T. Germer, A. Wiegering
Publikováno v:
BJS Open, Vol 3, Iss 5, Pp 672-677 (2019)
Background Colonic cancer is the most common cancer of the gastrointestinal tract. The aim of this study was to determine mortality rates following colonic cancer resection and the effect of hospital caseload on in‐hospital mortality in Germany. Me
Externí odkaz:
https://doaj.org/article/24957f533d7e444d970500343950ddb7
Targeting bromodomain-containing protein 4 (BRD4) inhibits MYC expression in colorectal cancer cells
Autor:
Otto, C., Schmidt, S., Kastner, C., Denk, S., Kettler, J., Müller, N., Germer, C.T., Wolf, E., Gallant, P., Wiegering, A.
Publikováno v:
In Neoplasia November 2019 21(11):1110-1120
Autor:
Albert Busch, Jessica Pauli, Greg Winski, Sonja Bleichert, Ekaterina Chernogubova, Susanne Metschl, Hanna Winter, Matthias Trenner, Armin Wiegering, Christoph Otto, Johannes Fischer, Judith Reiser, Julia Werner, Joy Roy, Christine Brostjan, Christoph Knappich, Hans-Henning Eckstein, Valentina Paloschi, Lars Maegdefessel
Publikováno v:
JCI Insight, Vol 6, Iss 15 (2021)
Abdominal aortic aneurysm (AAA) is a disease with high morbidity and mortality, especially when ruptured. The rationale of this study was to evaluate the repurposing of lenvatinib, a multi–tyrosine kinase inhibitor, in limiting experimental AAA gro
Externí odkaz:
https://doaj.org/article/aac1ee9249d0448ab8daa9aa9135c5d1
Akademický článek
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Autor:
Anne Hendricks, Sophie Müller, Martin Fassnacht, Christoph-Thomas Germer, Verena A. Wiegering, Armin Wiegering, Joachim Reibetanz
Publikováno v:
Cancers, Vol 14, Iss 2, p 291 (2022)
(1) Background: Locoregional lymphadenectomy (LND) in adrenocortical carcinoma (ACC) may impact oncological outcome, but the findings from individual studies are conflicting. The aim of this systematic review and meta-analysis was to determine the on
Externí odkaz:
https://doaj.org/article/43cc346c1ea44389a1ff0dcbf4407f43