Zobrazeno 21 - 30
of 288
pro vyhledávání: '"Wei-Yi Ong"'
Publikováno v:
Neuromolecular medicine. 24(4)
The SARS-CoV-2 virus gains entry to cells by binding to angiotensin-converting enzyme 2 (ACE2). Since circumventricular organs and parts of the hypothalamus lack a blood-brain barrier, and immunohistochemical studies demonstrate that ACE2 is highly e
Autor:
Sandra Soh, Wei-Yi Ong
Publikováno v:
Cells; Volume 11; Issue 3; Pages: 457
Cells, Vol 11, Iss 457, p 457 (2022)
Cells, Vol 11, Iss 457, p 457 (2022)
Withanolide A is a naturally occurring phytochemical that is found in Ashwagandha (Withania somnifera, fam. Solanaceae) or Indian Ginseng. In the current study, we elucidated the effect of withanolide A on 7-ketocholesterol (7KC) induced injury in hC
Autor:
Wan Shun Daniel Tan, Wei-Yi Ong, Sally Shuxian Koh, Wai Shiu Fred Wong, Deron R. Herr, Ting Yu Amelia Yam, Kanokporn Chayaburakul
Publikováno v:
Neuromolecular Medicine
Microglial cells are resident macrophages of the central nervous system (CNS) that respond to bioactive lipids such as docosahexaenoic acid (DHA). Low micromolar concentrations of DHA typically promote anti-inflammatory functions of microglia, but hi
Autor:
Peiyan Wong, Wei Lun Seow, Wee Siong Chew, Deron R. Herr, Wei Wang, Federico Torta, Wei-Yi Ong, Ping Xiang, Jing Kai Chang, Raghav Sundar, Aishwarya Bandla, Markus R. Wenk, Brenda Wan Shing Lam, Kanokporn Chayaburakul, Violeta Lopez
Publikováno v:
Journal of Biological Chemistry. 295:1143-1152
Platinum-based therapeutics are used to manage many forms of cancer, but frequently result in peripheral neuropathy. Currently, the only option available to attenuate chemotherapy-induced neuropathy is to limit or discontinue this treatment. Sphingos
Autor:
Hidayat Lokman, Huck-Hui Ng, Audrey Tze Ting Khoo, Wei-Yi Ong, Junghyun Jo, Grace Lim, Hoang Dai Tran, Seung-Jae Lee, Weonjin Yu, Lin Yang, Lai Ping Yaw, Ya Yin Chang, Jessica Jiaxin Xie, Kah-Leong Lim, Bin Xiao, Eng-King Tan, Tzuen Yih Saw, Byung Chul Jung, Alfred Xuyang Sun, Hyunsoo Shawn Je
Publikováno v:
Annals of neurology. 90(3)
Objective: We utilized human midbrain-like organoids (hMLOs) generated from human pluripotent stem cells carrying glucocerebrosidase gene (GBA1) and α-synuclein (α-syn; SNCA) perturbations to investigate genotype-to-phenotype relationships in Parki
Publikováno v:
Molecular Neurobiology. 57:372-392
Autotaxin (ATX) is a soluble extracellular enzyme that is abundant in mammalian plasma and cerebrospinal fluid (CSF). It has two known enzymatic activities, acting as both a phosphodiesterase and a phospholipase. The majority of its biological effect
Autor:
Jasmine Hui Min Lee, Tatsuma Hind, Jerold Chun, Siew Mon Lim, Nicholas Wei Jie Hay, Wei-Yi Ong, Malavika Srikanth, Deron R. Herr, Wee Siong Chew, Rich Rivera
Publikováno v:
European Journal of Pharmacology. 841:49-56
Lysophosphatidic acid receptor 1 (LPA1) is one of six G protein-coupled receptors (GPCRs) activated by the bioactive lipid, lysophosphatidic acid (LPA). Previous studies have shown that LPA1 signaling plays a major role in the pathophysiology of neur
Autor:
Malavika Srikanth, Kalashobini Chandrasaharan, Deron R. Herr, Wei-Yi Ong, Xinyuan Zhao, Kanokporn Chayaburakul
Publikováno v:
NeuroMolecular Medicine. 20:504-514
DHA is one of the most abundant fatty acids in the brain, largely present in stores of membrane phospholipids. It is readily released by the action of phospholipase A2 and is known to induce anti-inflammatory and neurotrophic effects. It is not thoug
Autor:
Ping, Xiang, Wee Siong, Chew, Wei Lun, Seow, Brenda Wan Shing, Lam, Wei-Yi, Ong, Deron R, Herr
Publikováno v:
Neurochemistry international. 146
Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid which modulates vascular integrity through its receptors, S1P
Autor:
Xin Ying, Chua, Leona T Y, Ho, Ping, Xiang, Wee Siong, Chew, Brenda Wan Shing, Lam, Christopher P, Chen, Wei-Yi, Ong, Mitchell K P, Lai, Deron R, Herr
Publikováno v:
Neuromolecular medicine. 23(1)
Sphingosine 1-phosphates (S1Ps) are bioactive lipids that mediate a diverse range of effects through the activation of cognate receptors, S1P