Zobrazeno 51 - 60
of 286
pro vyhledávání: '"Vivianna, M Van Deerlin"'
Autor:
Hayley Richardson, John Q. Trojanowski, David A. Wolk, Vivianna M. Van Deerlin, EunRan Suh, Brian Alfaro, Virginia M.-Y. Lee, Jeffrey J. Nirschl, Edward B. Lee, Nicholas Loh, Matias Porras-Paniagua, John L. Robinson, Sharon X. Xie
Publikováno v:
Brain
Cerebral amyloid angiopathy (CAA), limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) and Lewy bodies occur in the absence of clinical and neuropathological Alzheimer’s disease, but their prevalence and severity
Autor:
Pentti J. Tienari, James B. Leverenz, Nahid Tayebi, Gabriele Mora, Bradley F. Boeve, Laura Palmer, Steve M. Gentleman, Ellen Sidransky, Pau Pastor, Liana S. Rosenthal, G. Xiromerisiou, Sara Saez-Atienzar, Francesco Landi, Scott M. Kaiser, Qinwen Mao, Claire Troakes, Peter St George-Hyslop, Andrea Calvo, Suzanne Lesage, Mario Masellis, Randy Woltjer, Marilyn S. Albert, Thomas T. Warner, Lorraine N. Clark, Gregory Klein, Charles Duyckaerts, Seth Love, Ed Monuki, Lawrence S. Honig, Kelley Faber, Dennis W. Dickson, Lucy Norcliffe-Kaufmann, Cornelis Blauwendraat, Ronald C. Kim, Kevin Morgan, Clifton L. Dalgard, Joshua T. Geiger, Ali Torkamani, Jinhui Ding, Juan Fortea, Eliezer Masliah, Ekaterina Rogaeva, Matthew H. Perkins, Clemens R. Scherzer, John Q. Trojanowski, Zbigniew K. Wszolek, Glenda M. Halliday, Jordi Clarimón, Sonja W. Scholz, Olaf Ansorge, Makayla K. Portley, Toshiko Tanaka, Mary B. Makarious, Safa Al-Sarraj, Giancarlo Logroscino, John D. Eicher, Neill R. Graff-Radford, Carmen Lage, Ziv Gan-Or, Francesca Brett, Alison Goate, Raffaele Ferrari, John C. Morris, J. Raphael Gibbs, Lynn M. Bekris, Jose-Alberto Palma, Angela K. Hodges, Regina H. Reynolds, Alexis Brice, Monica Diez-Fairen, Coralie Viollet, Patrick May, Minna Oinas, Erika Salvi, Vivianna M. Van Deerlin, Estrella Morenas-Rodríguez, Anni Moore, Zane Jaunmuktane, Eileen H. Bigio, Daniele Cusi, Douglas Galasko, Ruth Chia, Kathy L. Newell, Isabel Santana, Claudia Schulte, David Goldstein, Thomas Gasser, Owen A. Ross, Walter A. Kukull, Tatiana Foroud, Chad A. Caraway, David A. Bennett, Samreen Ahmed, Lilah M. Besser, Antonio Canosa, Daniel Alcolea, Yevgeniya Abramzon, Elisabet Londos, Laura Parkkinen, Sandra E. Black, Eric Topol, Marya S. Sabir, Olga Pletnikova, Grisel Lopez, Tanis J. Ferman, Johannes Attems, Matthew J. Barrett, Margaret E. Flanagan, Horacio Kaufmann, Stuart Pickering Brown, Jon Infante, Ryan C. Bohannan, Alberto Lleó, Eloy Rodríguez-Rodríguez, Huw R. Morris, Gianluca Floris, Ted M. Dawson, Maura Brunetti, Alan E. Renton, Andrew B. Singleton, Karen Marder, Alan J. Thomas, Pascual Sanchez-Juan, Adriano Chiò, Nigel J. Cairns, David J. Stone, Tammaryn Lashley, Mike A. Nalls, Bernardino Ghetti, Sara Bandres-Ciga, Zalak Shah, Ian G. McKeith, Susan M. Resnick, Julia Keith, Liisa Myllykangas, Diego Albani, Christopher M. Morris, Vikram Shakkottai, M. Ryten, Ronald L. Walton, Isabel González-Aramburu, Luigi Ferrucci, Bryan J. Traynor, Amanda B. Kuzma, Afina W. Lemstra, Thomas G. Beach, Juan C. Troncoso, Emil K. Gustavsson, Maurizio Grassano, John Hardy, Geidy E. Serrano, Rejko Krüger, Dag Aarsland, Bension S. Tilley, Dena G. Hernandez
The genetic basis of Lewy body dementia (LBD) is not well understood. Here, we performed whole-genome sequencing in large cohorts of LBD cases and neurologically healthy controls to study the genetic architecture of this understudied form of dementia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d60a2822fe0ec61643d2f0301fa609c
https://doi.org/10.1101/2020.07.06.185066
https://doi.org/10.1101/2020.07.06.185066
Autor:
Edward B. Lee, Xuran Wang, Aivi T. Nguyen, EunRan Suh, David Choi, Kathryn Roeder, Zhen Miao, Vivianna M. Van Deerlin, Kui Wang, Joshua A Azevedo, Gang Hu, Mingyao Li
Publikováno v:
Acta neuropathologica
Beta-amyloid deposition is a defining feature of Alzheimer's disease (AD). How genetic risk factors, like APOE and TREM2, intersect with cellular responses to beta-amyloid in human tissues is not fully understood. Using single-nucleus RNA sequencing
Autor:
Andrew Siderowf, Meredith Spindler, Rebecca Lobrovich, Corey T. McMillan, Claire Peterson, David A. Wolk, Daniel T. Ohm, John Q. Trojanowski, Katheryn A.Q. Cousins, Edward B. Lee, Andres Deik, David J. Irwin, Vivianna M. Van Deerlin, Garrett S. Gibbons, Lauren Elman, Murray Grossman
Publikováno v:
Acta Neuropathol
Neurodegeneration of the locus coeruleus (LC) in age-related neurodegenerative diseases such as Alzheimer's disease (AD) is well documented. However, detailed studies of LC neurodegeneration in the full spectrum of frontotemporal lobar degeneration (
Autor:
Daniel Weintraub, EunRan Suh, Howard I. Hurtig, Thomas F. Tropea, John Q. Trojanowski, Alice Chen-Plotkin, David L Dai, Edward B. Lee, Vivianna M. Van Deerlin, John L. Robinson
Publikováno v:
Acta Neuropathol
Growing evidence suggests overlap between Alzheimer’s disease (AD) and Parkinson’s disease (PD) pathophysiology in a subset of patients. Indeed, 50–80% of autopsy cases with a primary clinicopathological diagnosis of Lewy body disease (LBD) –
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e171d239a0f29a6d2f8a952189bb3f7
https://doi.org/10.1101/2020.04.07.20056614
https://doi.org/10.1101/2020.04.07.20056614
Autor:
Nigel J. Cairns, David J. Stone, Tamas Revesz, Rita Guerreiro, Janice L. Holton, Jose Bras, Andrew J. Lees, Tanis J. Ferman, Afina W. Lemstra, Eliezer Masliah, Pentti J. Tienari, Pau Pastor, Ronald C. Petersen, Geidy E. Serrano, Celia Kun-Rodrigues, Elisabet Londos, Henrik Zetterberg, Dena G. Hernandez, John C. Morris, Tatiana Orme, Andrew B. Singleton, Owen A. Ross, Ekaterina Rogaeva, Thomas G. Beach, Karen Marder, Claire Troakes, Tammaryn Lashley, Kevin Morgan, Peter St George-Hyslop, Suzanne Lesage, Laura Parkkinen, Olaf Ansorge, Dennis W. Dickson, Glenda M. Halliday, John Q. Trojanowski, Liisa Myllykangas, Lorraine N. Clark, Isabel Santana, Neill R. Graff-Radford, Brad F. Boeve, Safa Al-Sarraj, Douglas Galasko, Minna Oinas, Vivianna M. Van Deerlin, Yaroslau Compta, John Hardy, Valentina Escott-Price, Lawrence S. Honig, Claire E. Shepherd, David M. A. Mann, Stuart Pickering-Brown, Lee Darwent
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-11 (2020)
Orme, T, Hernandez, D, Ross, O A, Kun-Rodrigues, C, Darwent, L, Shepherd, C E, Parkkinen, L, Ansorge, O, Clark, L, Honig, L S, Marder, K, Lemstra, A, Rogaeva, E, St George-Hyslop, P, Londos, E, Zetterberg, H, Morgan, K, Troakes, C, Al-Sarraj, S, Lashley, T, Holton, J, Compta, Y, Van Deerlin, V, Trojanowski, J Q, Serrano, G E, Beach, T G, Lesage, S, Galasko, D, Masliah, E, Santana, I, Pastor, P, Tienari, P J, Myllykangas, L, Oinas, M, Revesz, T, Lees, A, Boeve, B F, Petersen, R C, Ferman, T J, Escott-Price, V, Graff-Radford, N, Cairns, N J, Morris, J C, Pickering-Brown, S, Mann, D, Halliday, G, Stone, D J, Dickson, D W, Hardy, J, Singleton, A, Guerreiro, R & Bras, J 2020, ' Analysis of neurodegenerative disease-causing genes in dementia with Lewy bodies ', Acta Neuropathologica Communinications, vol. 8, no. 1, 5, pp. 5 . https://doi.org/10.1186/s40478-020-0879-z
Acta Neuropathologica Communications
Acta Neuropathologica Communinications, 8(1):5. BioMed Central
Universidad de Barcelona
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-11 (2020)
Orme, T, Hernandez, D, Ross, O A, Kun-Rodrigues, C, Darwent, L, Shepherd, C E, Parkkinen, L, Ansorge, O, Clark, L, Honig, L S, Marder, K, Lemstra, A, Rogaeva, E, St George-Hyslop, P, Londos, E, Zetterberg, H, Morgan, K, Troakes, C, Al-Sarraj, S, Lashley, T, Holton, J, Compta, Y, Van Deerlin, V, Trojanowski, J Q, Serrano, G E, Beach, T G, Lesage, S, Galasko, D, Masliah, E, Santana, I, Pastor, P, Tienari, P J, Myllykangas, L, Oinas, M, Revesz, T, Lees, A, Boeve, B F, Petersen, R C, Ferman, T J, Escott-Price, V, Graff-Radford, N, Cairns, N J, Morris, J C, Pickering-Brown, S, Mann, D, Halliday, G, Stone, D J, Dickson, D W, Hardy, J, Singleton, A, Guerreiro, R & Bras, J 2020, ' Analysis of neurodegenerative disease-causing genes in dementia with Lewy bodies ', Acta Neuropathologica Communinications, vol. 8, no. 1, 5, pp. 5 . https://doi.org/10.1186/s40478-020-0879-z
Acta Neuropathologica Communications
Acta Neuropathologica Communinications, 8(1):5. BioMed Central
Dementia with Lewy bodies (DLB) is a clinically heterogeneous disorder with a substantial burden on healthcare. Despite this, the genetic basis of the disorder is not well defined and its boundaries with other neurodegenerative diseases are unclear.
Autor:
Johannes Brettschneider, Jon B Toledo, Vivianna M Van Deerlin, Lauren Elman, Leo McCluskey, Virginia M-Y Lee, John Q Trojanowski
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39216 (2012)
We evaluated clinicopathological correlates of upper motor neuron (UMN) damage in amyotrophic lateral sclerosis (ALS), and analyzed if the presence of the C9ORF72 repeat expansion was associated with alterations in microglial inflammatory activity.Mi
Externí odkaz:
https://doaj.org/article/d486916b7f83428a8465f32cb4a2239e
Autor:
Samuel Maiser, Yuen T. So, Vivianna M. Van Deerlin, Gang Wu, Lauren Elman, James Caress, Evadnie Rampersaud, Colin Quinn, Corey T. McMillan, Murray Grossman, Joanne Wuu, Ted M. Burns, Adam C. Naj, Andrea Swenson, Jin Sha, Carlayne E. Jackson, Wenan Chen, Leo McCluskey, Edward B. Lee, Jeffrey Statland, Katerina Placek, J. Paul Taylor, Philip A. Cook, James C. Gee, J. S. Katz, John Q. Trojanowski, John Ravits, Volkan Granit, Michael Benatar, Rosa Rademakers, David J. Irwin, David Walk, Erik P. Pioro, Laura Hennessy
Amyotrophic lateral sclerosis (ALS) is a multi-system disease characterized primarily by progressive muscle weakness. Cognitive dysfunction is commonly observed in patients, however factors influencing risk for cognitive dysfunction remain elusive. U
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c3c23940e3321352de1f68b94f91cee
https://doi.org/10.1101/2019.12.23.19014407
https://doi.org/10.1101/2019.12.23.19014407
Autor:
Ole A. Andreassen, Vivianna M. Van Deerlin, David Simon, Claire E. Wegel, Guido Alves, Ruwani Wijeyekoon, Jodi Maple-Grødem, Alastair J. Noyce, Roger A. Barker, Bart P.C. van de Warrenburg, Peter Heutink, Shirley Eberly, J. Raphael Gibbs, Alexis Brice, Kumaraswamy Naidu Chitrala, Lasse Pihlstrøm, Marlies van Nimwegen, Khanh-Dung H. Nguyen, Ganqiang Liu, Bernard Ravina, Clemens R. Scherzer, Jean-Christophe Corvol, Bastiaan R. Bloem, Jacobus J. van Hilten, Karol Estrada, Faraz Faghri, Jonathan R. Evans, Daniel Weintraub, Ole-Bjørn Tysnes, Aaron G. Day-Williams, Hampton L. Leonard, Jonggeol J. Kim, Fabrice Danjou, David P. Breen, Samantha J. Hutten, Andrew B. Singleton, Hirotaka Iwaki, Peggy Auinger, Mike A. Nalls, Kirsten M. Scott, Dena G. Hernandez, Mathias Toft, Jacqueline Rick, Caroline H. Williams-Gray, Cornelis Blauwendraat
Publikováno v:
2019, ' Genomewide association study of Parkinson's disease clinical biomarkers in 12 longitudinal patients' cohorts ', Movement Disorders, vol. 34, no. 12 . https://doi.org/10.1002/mds.27845
Movement Disorders, 34, 1839-1850
Movement disorders 34(12), 1839-1850 (2019). doi:10.1002/mds.27845
Mov Disord
Movement Disorders
Movement Disorders, 34, 12, pp. 1839-1850
Movement Disorders, 34, 1839-1850
Movement disorders 34(12), 1839-1850 (2019). doi:10.1002/mds.27845
Mov Disord
Movement Disorders
Movement Disorders, 34, 12, pp. 1839-1850
Item does not contain fulltext BACKGROUND: Several reports have identified different patterns of Parkinson's disease progression in individuals carrying missense variants in GBA or LRRK2 genes. The overall contribution of genetic factors to the sever
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d75d743e4735219496720da03a92501
https://www.pure.ed.ac.uk/ws/files/112990604/Breen_GWAS_MovtDisorders.pdf
https://www.pure.ed.ac.uk/ws/files/112990604/Breen_GWAS_MovtDisorders.pdf
Autor:
Edward B. Lee, David J. Irwin, Murray Grossman, John L. Robinson, Sharon X. Xie, John Q. Trojanowski, Garrett S. Gibbons, Carrie Caswell, Bruce L. Miller, Ning Yan, EunRan Suh, Virginia M.-Y. Lee, Vivianna M. Van Deerlin
Publikováno v:
J Neuropathol Exp Neurol
Journal of neuropathology and experimental neurology, vol 79, iss 3
Journal of neuropathology and experimental neurology, vol 79, iss 3
Distinct neuronal and glial tau pathologies define corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP). Additional Alzheimer disease, TDP-43, and Lewy body copathologies are also common. The interplay of these pathologies with cl