Zobrazeno 71 - 80
of 528
pro vyhledávání: '"Vipul Jairath"'
Autor:
Jiannan Li, Sinan Lin, Jie Wang, Brian G. Feagan, Minhu Chen, Chenchen Qian, David H. Bruining, Dominik Bettenworth, Vipul Jairath, Florian Rieder, Ren Mao, Stenosis Therapy
Publikováno v:
Physiol Rev
Intestinal fibrosis is considered an inevitable complication of Crohn’s disease (CD) that results in symptoms of obstruction and stricture formation. Endoscopic or surgical treatment is required to treat the majority of patients. Progress in the ma
Autor:
Geert R. D'Haens, Florian Rieder, Rocio Sedano, Tran M Nguyen, Ahmed Almradi, Claire E Parker, Brian G. Feagan, Christopher Ma, Lisa M. Shackelton, William J. Sandborn, Vipul Jairath
Publikováno v:
Inflamm Bowel Dis
Background Several indices exist to measure pouchitis disease activity; however, none are fully validated. As an initial step toward creating a validated instrument, we identified pouchitis disease activity indices, examined their operating propertie
Autor:
Yasi Xiao, Nicolas Benoit, Rocio Sedano, Vipul Jairath, Neeraj Narula, Jeffrey D. McCurdy, Greg Rosenfeld, Waqqas Afif, Peter L. Lakatos, Talat Bessissow
Publikováno v:
Digestive Diseases and Sciences. 67:5213-5219
Treatment options for acute severe ulcerative colitis (ASUC) are limited. Tofacitinib, an approved treatment for moderate to severe ulcerative colitis, could be a potential rescue therapy for ASUC given its rapid onset of action.To evaluate the effec
Autor:
Mathieu Uzzan, Yoram Bouhnik, Maria Abreu, Harris A Ahmad, Shashi Adsul, Hilde Carlier, Marla Dubinsky, Matthew Germinaro, Vipul Jairath, Irene Modesto, Eric Mortensen, Neeraj Narula, Ezequiel Neimark, Alessandra Oortwijn, Marijana Protic, David T Rubin, Young S Oh, Jolanta Wichary, Laurent Peyrin-Biroulet, Walter Reinisch
Publikováno v:
Journal of Crohn's and Colitis.
BackgroundRates of enrolment in clinical trials in inflammatory bowel disease [IBD] have decreased dramatically in recent years. This has led to delays, increased costs and failures to develop novel treatments.AimsThe aim of this work is to describe
Autor:
Luca Massimino, Orazio Palmieri, Amanda Facoetti, Davide Fuggetta, Salvatore Spanò, Luigi Antonio Lamparelli, Silvia D'Alessio, Stefania Cagliani, Federica Furfaro, Ferdinando D'Amico, Alessandra Zilli, Gionata Fiorino, Tommaso Lorenzo Parigi, Daniele Noviello, Anna Latiano, Fabrizio Bossa, Tiziana Latiano, Alessandra Pirola, Luca Mologni, Rocco Giovanni Piazza, Danilo Abbati, Francesco Perri, Chiara Bonini, Laurent Peyrin-Biroulet, Alberto Malesci, Vipul Jairath, Silvio Danese, Federica Ungaro
ObjectivesUlcerative colitis (UC) is a chronic inflammatory disorder of unknown aetiology. Gut virome dysbiosis is fundamental in UC progression, although its role in the early phases of the disease is far from fully understood. Therefore, we sought
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccd4194b70c9b5643230a2934eeab1d6
https://hdl.handle.net/10281/414797
https://hdl.handle.net/10281/414797
Autor:
Virginia Solitano, Antonio Facciorusso, Dermot P.B. McGovern, Tran Nguyen, Ruben J. Colman, Lily Zou, Brigid S. Boland, Silje W. Syversen, Kristin Kaasen Jørgensen, Christopher Ma, Alessandro Armuzzi, Aze Wilson, Vipul Jairath, Siddharth Singh
Publikováno v:
Clinical gastroenterology and hepatology.
Background & Aims: Identifying patients at high risk of immunogenicity is important when selecting tumor necrosis factor (TNF)-α antagonists in patients with immune-mediated inflammatory diseases (IMIDs). We evaluated the association HLA-DQA1∗05 g
Publikováno v:
Nature reviews. Gastroenterologyhepatology.
Publikováno v:
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, vol 20, iss 12
Clin Gastroenterol Hepatol
Clin Gastroenterol Hepatol
Background & aimsPatients with Crohn's disease (CD) treated with ustekinumab who experience inadequate response, or loss of response after standard induction and/or maintenance dosing may benefit from dose escalation. We conducted a systematic review
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c6178ce5b3a9a18fa70971346b665ff
https://escholarship.org/uc/item/270528g4
https://escholarship.org/uc/item/270528g4
Publikováno v:
Journal of Biopharmaceutical Statistics. 32:740-767
Concordance refers to the probability that subjects with high values on one variable also have high values on another variable. This index has wide application in practice, as a measure of effect size in group-comparison studies, an index of accuracy
Autor:
Emily C.L. Wong, Parambir S. Dulai, John K. Marshall, Vipul Jairath, Walter Reinisch, Neeraj Narula
Publikováno v:
Alimentary Pharmacology & Therapeutics. 55:1151-1159
It is unclear whether improvement in patient-reported outcomes (PROs) relative to baseline symptom burden in Crohn's disease (CD) is associated with subsequent endoscopic remission.To evaluate the relationship between dominant PRO resolution post-ind