Zobrazeno 51 - 60
of 98
pro vyhledávání: '"Vincent W. Keng"'
Autor:
Stephen C. Schmechel, David A. Largaespada, Vincent W. Keng, Anthony E. Rizzardi, Margaret H. Collins, Colleen L. Forster, Amanda L. Halfond, Caitlin B. Conboy, Eric P. Rahrmann, Aaron L. Sarver, Andrew D. Greeley, Adrienne L. Watson, Nancy Ratner, Margaret R. Wallace, Leah K. Anderson, Kwangmin Choi, Branden S. Moriarity, Brian R. Wahl
Publikováno v:
Cancer Discovery. 3:674-689
Genetic changes required for the formation and progression of human Schwann cell tumors remain elusive. Using a Sleeping Beauty forward genetic screen, we identified several genes involved in canonical Wnt signaling as potential drivers of benign neu
Autor:
Christopher L. Moertel, Adrienne L. Watson, Vincent W. Keng, David A. Largaespada, Natalie K. Wolf, Bernat Gel, Dominic A. Beckmann, Margaret H. Collins, Eduard Serra, Margaret R. Wallace, Aaron L. Sarver, Branden S. Moriarity, Kwangmin Choi, Nancy Ratner, Eric P. Rahrmann
Publikováno v:
Nature genetics
Malignant peripheral nerve sheath tumors (MPNSTs) are sarcomas of Schwann cell lineage origin that occur sporadically or in association with the inherited syndrome neurofibromatosis type 1. To identify genetic drivers of MPNST development, we used th
Autor:
Eric B. Schwartz, Walter J. Jessen, Jianqiang Wu, James R. Fuchs, Yuanshu Zou, Kevin A. T. Silverstein, Jose A. Cancelas, Deanna M. Patmore, Kwangmin Choi, Mi-Ok Kim, Edwin Jousma, Ami V. Patel, David A. Largaespada, Eva Dombi, Gang Huang, Barbara R. Tschida, David E. Levy, Jed J. Kendall, Vincent W. Keng, Robert J. Spinner, Danhua Fan, Nancy Ratner, Anat Stemmer-Rachamimov
Publikováno v:
Cell Reports, Vol 14, Iss 8, Pp 1979-1990 (2016)
SummaryTo identify genes and signaling pathways that initiate Neurofibromatosis type 1 (NF1) neurofibromas, we used unbiased insertional mutagenesis screening, mouse models, and molecular analyses. We mapped an Nf1-Stat3-Arid1b/β-catenin pathway tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d4cd23be8f1a14cb8ed8e1e19cb857a
https://europepmc.org/articles/PMC4782770/
https://europepmc.org/articles/PMC4782770/
Autor:
David A. Largaespada, Eric P. Rahrmann, Walter J. Jessen, Barbara R. Tschida, Tilat A. Rizvi, Nancy Ratner, Christopher L. Moertel, Adrienne L. Watson, Margaret H. Collins, Vincent W. Keng
Publikováno v:
Cancer Research. 72:3405-3413
The genetic evolution from a benign neurofibroma to a malignant sarcoma in patients with neurofibromatosis type 1 (NF1) syndrome remains unclear. Schwann cells and/or their precursor cells are believed to be the primary pathogenic cell in neurofibrom
Autor:
Barbara R. Tschida, Vincent W. Keng, Margaret H. Collins, David A. Largaespada, Hua Li, Adrienne L. Watson, Tilat A. Rizvi, Kwangmin Choi, Branden S. Moriarity, Margaret R. Wallace, Eric P. Rahrmann, Nancy Ratner
Publikováno v:
Sarcoma
Sarcoma, Vol 2012 (2012)
Sarcoma, Vol 2012 (2012)
The genetic mechanisms involved in the transformation from a benign neurofibroma to a malignant sarcoma in patients with neurofibromatosis-type-1- (NF1-)associated or sporadic malignant peripheral nerve sheath tumors (MPNSTs) remain unclear. It is hy
Publikováno v:
Hepatology. 53:781-790
The mechanisms associated with hepatitis B virus (HBV)–induced hepatocellular carcinoma (HCC) remain elusive, and there are currently no well-established animal models for studying this disease. Using the Sleeping Beauty transposon as a delivery sy
Autor:
David A. Largaespada, Barbara R. Tschida, Amy P. Chiu, Dewi Kenneth Rowlands, Vincent W. Keng, Xiao-Xiao Li, Lilian H. Lo
Publikováno v:
Cancer Research. 78:5183-5183
Metastases account for most cancer-related deaths as a result of primary cancer spreading to distant sites. Amongst human hepatocellular carcinoma (HCC), there is a drastic decrease in the survival rate observed in patients with early stage localized
Autor:
Stephen C. Ekker, Christian Schmedt, Vincent W. Keng, Barbara J. Ryan, David A. Largaespada, Kirk J. Wangensteen, Darius Balciunas
Publikováno v:
Genetics. 183:1565-1573
Insertional mutagenesis screens play an integral part in the annotating of functional data for all sequenced genes in the postgenomic era. Chemical mutagenesis screens are highly efficient but identifying the causative gene can be a laborious task. O
Publikováno v:
Genome Research. 18:859-868
Retrotransposons constitute a major component of the genome and their proliferation significantly impacts genome evolution. Retrotransposons can propagate autonomously or nonautonomously. Nonautonomous type transposition occurs through trans-compleme
Retrotransposons Influence the Mouse Transcriptome: Implication for the Divergence of Genetic Traits
Publikováno v:
Genetics. 176:815-827
Massive accumulation of retrotransposons, comprising >40% of human and mouse genomes, is one of the major events in the evolution of the genome. However, most retrotransposons have lost retrotransposition competency, which makes studying their role i