Zobrazeno 21 - 30
of 141
pro vyhledávání: '"Toru Sakura"'
Autor:
Hiroaki Shimizu, Toru Sakura, Takayuki Saitoh, Akihiko Yokohama, Takuma Ishizaki, Nahoko Hatsumi, Satoru Takada, Hiroshi Handa
Publikováno v:
Leukemia research. 103
Additional cytogenetic abnormality (ACA) acquisition at relapse has been recognized as clonal evolution at the cytogenetic level, and has a significant prognostic impact on relapsed acute myeloid leukemia (AML) patients. We retrospectively investigat
Autor:
Yoshihiro Hatta, Akiko Saito, Maki Hagihara, Itaru Matsumura, Yuichi Yahagi, Tsutomu Takahashi, Yoshiko Atsuta, Hiroatsu Iida, Naoki Mori, Isamu Sugiura, Koichiro Minauchi, Fumihiko Hayakawa, Akihiro Hirakawa, Kiyotoshi Imai, Tohru Murayama, Takeshi Saito, Yasushi Miyazaki, Etsuko Yamazaki, Hitoshi Kiyoi, Toru Sakura
Publikováno v:
International journal of hematology. 113(3)
This phase 1/2 study aimed to identify the maximum tolerated dose, the recommended phase 2 dose (RP2D), and efficacy of the clofarabine, etoposide, and cyclophosphamide combination regimen in adult patients with relapsed/refractory acute lymphoblasti
Autor:
Naohito Fujishima, Toru Sakura, Mine Harada, Tohru Murayama, Tetsuya Eto, Koichi Akashi, Kana Matsumoto, Junji Kishimoto, Kunihiko Morita, Naoyuki Uchida, Yoshinobu Maeda, Toshihiro Miyamoto, Shinichiro Mori, Takanori Teshima, Shuichi Taniguchi, Takuya Yamashita, Michihiro Hidaka, Goichi Yoshimoto
Publikováno v:
International journal of hematology. 112(4)
An optimal pretransplant conditioning regimen for allogeneic hematopoietic stem cell transplantation (allo-HSCT) in older adults has not been established. Three prospective multicenter phase II studies were conducted, in which 142 patients older than
Autor:
Shigehisa Tamaki, Akihiro Takeshita, Hitoshi Minamiguchi, Katsumichi Fujimaki, Hiroyuki Fujita, Masako Iwanaga, Yasushi Miyazaki, Yoshiko Atsuta, Yasunori Ueda, Akihiro Tomita, Toru Sakura, Masashi Sawa, Maki Hagihara, Itaru Matsumura, Masamitsu Yanada, Yoshihito Uchino, Nobuaki Dobashi, Yukio Kobayashi, Norio Asou, Yasuhiro Taniguchi, Hitoshi Kiyoi, Noriko Usui, Tomoki Naoe, Yoshinobu Maeda, Shigeki Ohtake, Rikio Suzuki
Publikováno v:
Annals of hematology. 99(12)
Significant advancements have been achieved with regard to the outcomes of acute promyelocytic leukemia (APL) patients through the introduction of all-trans retinoic acid; however, early hemorrhagic death and differentiation syndrome remain the major
Autor:
Nobuaki Dobashi, Yasushi Miyazaki, Shigeki Ohtake, Akihiro Takeshita, Yukako Obata, Noriko Usui, Toru Sakura, Hiroaki Furumaki, Yoshinobu Maeda, Rikio Suzuki, Masashi Sawa, Itaru Matsumura, Masamitsu Yanada, Masaru Nakagawa, Shigehisa Tamaki, Norio Asou, Yoshiko Atsuta, Maki Hagihara, Yasunori Ueda, Hitoshi Kiyoi, Tomoki Naoe, Hiroyuki Fujita, Yasuhiro Taniguchi, Katsumichi Fujimaki, Yukio Kobayashi
Publikováno v:
Leukemia. 33:358-370
Between April 2004 and December 2010, we conducted a prospective randomized controlled study comparing tamibarotene with all-trans retinoic acid (ATRA) in the maintenance therapy of newly diagnosed acute promyelocytic leukemia (APL), and here report
Autor:
Tsukasa Oda, Hiroaki Shimizu, Takuma Ishizaki, Tetsuhiro Kasamatsu, Toru Sakura, Hirokazu Murakami, Takayuki Saitoh, Yusuke Minato, Akihiko Yokohama, Makiko Takizawa, Noriyuki Takahashi, Takumi Hoshino, Hiroshi Handa, Norifumi Tsukamoto, Nanami Gotoh, Kana Souma
Publikováno v:
European journal of haematologyREFERENCES. 104(6)
OBJECTIVE Myelodysplastic syndromes (MDS), caused by various genetic mutations in hematopoietic stem cells, are associated with highly variable outcomes. Poly (ADP-ribose) polymerase-1 (PARP1) plays an important role in DNA damage repair and contribu
Autor:
Norifumi Tsukamoto, Hiroshi Handa, Tsukasa Oda, Takayuki Saitoh, Alkebsi Lobna, Akihiko Yokohama, Hiroaki Shimizu, Toru Sakura, Hirokazu Murakami, Nanami Gotoh, Takumi Hoshino, Tetsuhiro Kasamatsu, Noriyuki Takahashi, Yusuke Minato, Makiko Takizawa
Publikováno v:
International Journal of Hematology. 108:246-253
Recent studies have shown that tumors of relapsed acute myeloid leukemia (AML) present additional genetic mutations compared to the primary tumors. The base excision repair (BER) pathway corrects oxidatively damaged mutagenic bases and plays an impor
Autor:
Yukinori Nakamura, Ken-ichi Matsuoka, Naoyuki Uchida, Yasushi Miyazaki, Koji Iwato, Yoshiko Atsuta, Fumihiko Kimura, Yukiyasu Ozawa, Jun Aoki, Toru Sakura, Kazuteru Ohashi, Ken Ishiyama, Mineo Kurokawa, Yuichiro Nawa, Kazunari Aoki, Makoto Hirokawa, Hidehiro Itonaga, Koji Kato, Tatsuo Ichinohe, Takayuki Ishikawa
Publikováno v:
Biology of Blood and Marrow Transplantation. 24:840-848
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative therapeutic option for patients with chronic myelomonocytic leukemia (CMML). We retrospectively compared the post-transplantation outcomes of 159 patients with CMML who unde
Autor:
Mineo Kurokawa, Naoyuki Uchida, Michihiro Hidaka, Yukiyasu Ozawa, Toru Sakura, Kazuteru Ohashi, Naoki Kobayashi, Shinichi Kako, Yasuyuki Arai, Shuichi Mizuta, Makoto Onizuka, Junji Tanaka, Tetsuya Eto, Koji Iwato, Yoshiko Atsuta, Tadakazu Kondo, Kaoru Kahata, Takahiro Fukuda, Akio Shigematsu
Publikováno v:
American Journal of Hematology. 93:47-57
Allogeneic hematopoietic stem cell transplantation (HSCT) with the conventional cyclophosphamide and total body irradiation (CY/TBI) regimen is an essential therapeutic strategy for acute lymphoblastic leukemia (ALL) in adults. Medium-dose etoposide
Autor:
Kazuhiko Kakihana, Norio Asou, Toru Sakura, Hitoshi Kiyoi, Tohru Murayama, K Imai, Shigeki Ohtake, Yasushi Miyazaki, Yukio Kobayashi, Shin Fujisawa, Heiwa Kanamori, Yasunori Ueda, Takahiro Yamauchi, M. Kurokawa, Yasuhiko Miyata, Toshiaki Yujiri, Keitaro Matsuo, Fumihiko Hayakawa, Kazunori Ohnishi, Tomoki Naoe, Yoshikazu Ito, Isamu Sugiura, Noriko Usui
Publikováno v:
Leukemia. 32:626-632
High-dose methotrexate (Hd-MTX) therapy has recently been applied to the treatment of adult acute lymphoblastic leukemia (ALL) based on pediatric protocols; however, its effectiveness for adult ALL has not yet been confirmed in a rigorous manner. We