Zobrazeno 81 - 90
of 126
pro vyhledávání: '"Tomi P. Mäkelä"'
Publikováno v:
Cancer Research. 74:4857-4857
While the role of LKB1 mutations in the Peutz-Jeghers polyposis syndrome (PJS) is uncontroversial, the originating cell type remains unclear as Lkb1 mutations in both epithelial cells and stromal smooth muscle cells (SMCs) have been proposed as tumor
Autor:
Tea Vallenius, Tomi P. Mäkelä
Publikováno v:
Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics
Our understanding of cancer as a genetic disease is increasingly growing using information from genome-scale experimental approaches, and the focus is turning from analyzing single genes to analyzing signaling networks. Together with the first target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00e86f09fa871dfe1e27df008514dd74
https://doi.org/10.1002/047001153x.g105313
https://doi.org/10.1002/047001153x.g105313
Autor:
Tomi P. Mäkelä, Pia Alhopuro, F W M de Rooij, Lauri A. Aaltonen, Auli Karhu, Sanna K. Ylisaukko-oja, T Vogel, J.H.P. Wilson, P Katajisto, Virpi Launonen, Laura Näätsaari, I. P. M. Tomlinson, Gabriela Moeslein, Anne Marie Westerman, Rainer Lehtonen
Publikováno v:
University of Helsinki
British Journal of Cancer, 92(6), 1126-1129. Nature Publishing Group
British Journal of Cancer
British Journal of Cancer, 92(6), 1126-1129. Nature Publishing Group
British Journal of Cancer
Mutations in LKB1 lead to Peutz-Jeghers syndrome (PJS). However, only a subset of PJS patients harbours LKB1 mutations. We performed a mutation analysis of three genes encoding novel LKB1-interacting proteins, BRG1, STRADalpha, and MO25alpha, in 28 L
Autor:
Derrick J. Rossi, Ari Ristimäki, Lina Udd, Antti Ylikorkala, Heikki Järvinen, Pekka Katajisto, Anna—Maria Lahesmaa, Anna Lepistö, Tomi P. Mäkelä
Publikováno v:
Gastroenterology. 127(4)
Background & Aims: Peutz—Jeghers syndrome (PJS) is typically manifested as severe gastrointestinal polyposis. Polyps in PJS patients and in Lkb1 +/− mice that model PJS polyposis are frequently characterized by elevated cyclooxygenase-2 (COX-2).
Autor:
Henrik Spåhr, Vera Baraznenok, Tomas Linder, Camilla O. Samuelsen, Tomi P. Mäkelä, Claes M. Gustafsson, Steen Holmberg, Damien Hermand, Olga Khorosjutina
Publikováno v:
The Journal of biological chemistry. 278(51)
The fission yeast Schizosaccharomyces pombe has proved an important model system for cross-species comparative studies of many fundamental processes in the eukaryotic cell, such as cell cycle control and DNA replication. The RNA polymerase II transcr
Autor:
Tomi P. Mäkelä, Patrick Charnay, Derrick J. Rossi, Anders Paetau, Nina Korsisaari, Mark Henkemeyer
Publikováno v:
Journal of cell science. 115(Pt 22)
The mammalian Mat1 protein has been implicated in cell cycle regulation as part of the Cdk activating kinase (CAK), and in regulation of transcription as a subunit of transcription factor TFIIH. To address the role of Mat1 in vivo, we have used a Cre
Publikováno v:
Molecular biology of the cell. 12(12)
In normal cells, activation of cyclin-dependent kinases (cdks) requires binding to a cyclin and phosphorylation by the cdk-activating kinase (CAK). The Kaposi's sarcoma-associated herpesvirus encodes a protein with similarity to D-type cyclins. This
Autor:
Arno Pihlak, Tomi P. Mäkelä, Marianne Tiainen, Jean Vandenhaute, Thomas Westerling, Jean-Yves Thuret, Damien Hermand, Tea Vallenius, Guillaume Cottarel, Carl Mann
Publikováno v:
The EMBO journal. 20(1-2)
Activating phosphorylation of cyclin-dependent kinases (Cdks) is mediated by at least two structurally distinct types of Cdk-activating kinases (Caks): the trimeric Cdk7-cyclin H-Mat1 complex in metazoans and the single-subunit Cak1 in budding yeast.
Publikováno v:
The Journal of biological chemistry. 275(15)
The PDZ-LIM family of proteins (Enigma/LMP-1, ENH, ZASP/Cypher, RIL, ALP, and CLP-36) has been suggested to act as adapters that direct LIM-binding proteins to the cytoskeleton. Most interactions of PDZ-LIM proteins with the cytoskeleton have been id
Autor:
Päivi M. Ojala, Tomi P. Mäkelä, Kazuhito Yamamoto, Stanley J. Korsmeyer, Peter Biberfeld, Esmeralda Castaños-Velez
Publikováno v:
Nature cell biology. 2(11)
v-cyclin encoded by Kaposi's sarcoma herpesvirus/human herpesvirus 8 (KSHV or HHV8) associates with cellular cyclin-dependent kinase 6 (CDK6) to form a kinase complex that promotes cell-cycle progression, but can also induce apoptosis in cells with h