Zobrazeno 71 - 80
of 126
pro vyhledávání: '"Tomi P. Mäkelä"'
Autor:
Veijo Hukkanen, Riitta Alitalo, Harri Hirvonen, Tarja-Terttu Pelliniemi, Toivo T. Salmi, Sakari Knuutila, Tomi P. Mäkelä
Publikováno v:
Blood. 78:3012-3020
The myc proto-oncogenes encode nuclear phosphoproteins, which are believed to participate in the control of cell proliferation and differentiation. Deregulated expression of c-myc has been implicated in several human hematopoietic malignancies. We ha
Publikováno v:
European Journal of Cancer and Clinical Oncology. 27:1323-1327
11 Albert VA, Howard K, Geller AC, Miller DR, Prout MN, Lew RA. Years of potential life lost: another indicator of the impact of cutaneous malignant melanoma on society. J Am Acad Dewnatol 1990,23,308-310. Osterlind A, Tucker MA, Hou-Jensen K, et al.
Publikováno v:
Europe PubMed Central
Chromosomal abnormalities affecting proto-oncogenes are frequently detected in human cancer. Oncogenes of the myc family are activated in several types of tumors as a result of gene amplification or chromosomal translocation. We have recently found t
Autor:
Juha Partanen, Kari Alitalo, Elina Eerola, Lena Claesson-Welsh, Jaana Korhonen, H. Hirvonen, Tomi P. Mäkelä
Publikováno v:
The EMBO Journal. 10:1347-1354
We have previously identified two novel members of the fibroblast growth factor receptor (FGFR) gene family expressed in K562 erythroleukemia cells. Here we report cDNA cloning and analysis of one of these genes, named FGFR-4. The deduced amino acid
Autor:
Sampsa Hautaniemi, Tomi P. Mäkelä, Jianmin Wu, Tea Vallenius, Jukka Westermarck, Kristian Ovaska
Publikováno v:
Nature methods. 6(1)
There is an increasing demand for network analysis of protein-protein interactions (PPIs). We introduce a web-based protein interaction network analysis platform (PINA), which integrates PPI data from six databases and provides network construction,
Publikováno v:
Proceedings of the National Academy of Sciences. 87:8913-8917
Tyrosine phosphorylation is important in the transmission of growth and differentiation signals; known tyrosine kinases include several oncoproteins and growth factor receptors. Interestingly, some differentiated cell types, such as erythrocytes and
Autor:
Kari Vaahtomeri, Tomi P. Mäkelä, Niklas Ekman, Ronald A. DePinho, Eeva Ventelä, Ari Ristimäki, Pekka Katajisto, Robert Feil, Nabeel Bardeesy
Publikováno v:
Nature genetics. 40(4)
Germline mutations in STK11 (also known as LKB1) are found in individuals with Peutz-Jeghers syndrome (PJS) manifesting with gastrointestinal polyps that contain a prominent stromal component. Epithelia in polyps of Stk11(+/-) mice can retain a funct
Cellular organization into epithelial architecture maintains structural integrity and homeostasis by suppressing cell proliferation and apoptosis. However, it is unclear whether the epithelial organization is sufficient to block induction of cell-aut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b7d545a680ced6c564d54de2fd2d7bf
https://europepmc.org/articles/PMC1976192/
https://europepmc.org/articles/PMC1976192/
Publikováno v:
Cancer Genetics and Cytogenetics. 102:139-141
The antimitotic drug 2-methoxyestradiol is an end metabolite of catechol estrogens. In vivo, it arrests cells in mitosis by interfering with the dynamics of the mitotic spindle without disrupting tubulin formation. It has a mitotic index similar to t
Autor:
Johanna Sjöström, Tomi P. Mäkelä
Publikováno v:
eLS
The cell cycle and apoptosis are central gene-regulated cellular pathways. A number of diseases evolve due to deregulation of these pathways. Keywords: apoptosis; cell cycle; cancer; autoimmune disease; neurodegenerative disease