Zobrazeno 21 - 30
of 126
pro vyhledávání: '"Tomi P. Mäkelä"'
Autor:
Yan Yan, Tea Vallenius, Tomi P. Mäkelä, Iris P. L. Wong, Jorma J. Palvimo, Kari Vaahtomeri, Saara Ollila
Publikováno v:
Nature Communications
Article
AMP-activated protein kinase (AMPK) inhibits several anabolic pathways such as fatty acid and protein synthesis, and identification of AMPK substrate specificity would be useful to understand its role in particular cellular processes and
AMP-activated protein kinase (AMPK) inhibits several anabolic pathways such as fatty acid and protein synthesis, and identification of AMPK substrate specificity would be useful to understand its role in particular cellular processes and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66609806e6560b215a785df5efc6527b
http://hdl.handle.net/10138/165272
http://hdl.handle.net/10138/165272
Autor:
Tomi P. Mäkelä, Mira Heinonen, Alexandra Thiel, Marie-Christine Rio, Ari Ristimäki, Annabrita Hemmes, Kirsi Narko, Caj Haglund, Catherine Tomasetto
Publikováno v:
International Journal of Cancer. 131:1032-1041
Cyclooxygenase-2 (Cox-2) expression is a marker of reduced survival in gastric cancer patients, and inhibition of Cox-2 suppresses gastrointestinal carcinogenesis in experimental animal models. To investigate the role of Cox-2 in gastric carcinogenes
Autor:
Lina Udd, Tomi P. Mäkelä
Publikováno v:
Familial Cancer. 10:425-435
The Peutz-Jeghers syndrome (PJS) culprit kinase LKB1 phosphorylates and activates multiple intracellular kinases regulating cell metabolism and polarity. The relevance of each of these pathways is highly variable depending on the tissue type, but typ
Autor:
Timofey V. Tselykh, Tomi P. Mäkelä, Ying Yang, Katja Helenius, Heli K. J. Pessa, Mikko J. Frilander
Publikováno v:
Nucleic Acids Research
The relevance of serine 5 phosphorylation of RNA polymerase II carboxy-terminal domain during initiation has been difficult to determine in mammalian cells as no general in vivo Ser5 kinase has been identified. Here, we demonstrate that deletion of t
Publikováno v:
Molecular and Cellular Biology. 29:315-323
Mammalian Cdk7, cyclin H, and Mat1 form the kinase submodule of transcription factor IIH (TFIIH) and have been considered ubiquitously expressed elements of the transcriptional machinery. Here we found that Mat1 and Cdk7 levels are undetectable in ad
Autor:
Niklas Ekman, Marianne Tiainen, Tea Vallenius, Pekka Katajisto, Tomi P. Mäkelä, Kari Vaahtomeri, Anou Londesborough
Publikováno v:
Development. 135:2331-2338
Inactivation of the tumor suppressor kinase Lkb1 in mice leads to vascular defects and midgestational lethality at embryonic day 9-11 (E9-E11). Here, we have used conditional targeting to investigate the defects underlying the Lkb1(-/-) phenotype. En
Publikováno v:
Molecular and Cellular Biology. 27:6177-6182
The Cdk8 kinase and associated proteins form a nonessential transcriptional repressor module of the Mediator in the budding yeast Saccharomyces cerevisiae. Genetic analyses of this module have demonstrated functions ranging from environmental respons
Autor:
Tomi P. Mäkelä, Michael D. Schneider, Brett H. Graham, Derrick J. Rossi, Motoaki Sano, Min Xie, Fernando Scaglia, Noriaki Shimizu, Katja Helenius, Heinrich Taegtmeyer, Yasukatsu Izumi, Christopher R. Wilson, Lingyun Hu, E. Dale Abel, George E. Taffet, Robia G. Pautler, Sihem Boudina, Masanori Asakura, Anastasia Kralli, Hirotoshi Tanaka
Publikováno v:
Cell Metabolism. 5:129-142
The Cdk7/cyclin H/ménage-à-trois 1 (MAT1) heterotrimer has proposed functions in transcription as the kinase component of basal transcription factor TFIIH and is activated in adult hearts by Gq-, calcineurin-, and biomechanical stress-dependent pat
Autor:
Tea Vallenius, Lina Udd, Kari Vaahtomeri, Tomi P. Mäkelä, Marianne Tiainen, Pekka Katajisto, Niklas Ekman
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. 1775:63-75
Inactivating germline mutations in the LKB1 gene underlie Peutz-Jeghers syndrome characterized by hamartomatous polyps and an elevated risk for cancer. Recent studies suggest the involvement of LKB1 also in more common human disorders including diabe
Autor:
Ying Yang, Pekka Paivinen, Chang Xie, Alexis Leigh Krup, Tomi P. Makela, Keith E. Mostov, Jeremy F. Reiter
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
The mechanisms underlying tubular organ elongation remain poorly understood. Here, the authors show that primary cilia interpret Hedgehog signals to pattern the developing gut and that smooth muscle in the gut wall generates mechanical forces that di
Externí odkaz:
https://doaj.org/article/83752cdb44f4477cb1159ac65b303db8