Zobrazeno 61 - 70
of 153
pro vyhledávání: '"Thushan I de Silva"'
Autor:
Bozena Poller, Hayley Colton, Amy State, Cariad Evans, Alexander J Keeley, Alison Cope, Matthew Parker, Leeanne Tovey, Thushan I de Silva, Michael Ankcorn, Mohammad Raza, Mehmet Yavuz
Publikováno v:
Journal of Infection
The Journal of Infection
The Journal of Infection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06b9e505d81a9ffc3a3317038ab7019c
https://eprints.whiterose.ac.uk/166000/8/E_and_RdRP_assay_JoI_letter_accepted_version.pdf
https://eprints.whiterose.ac.uk/166000/8/E_and_RdRP_assay_JoI_letter_accepted_version.pdf
Autor:
Peter J. M. Openshaw, Cameron J Fairfield, Ewen M Harrison, Louise Sigfrid, Malcolm G Semple, Hayley E Hardwick, Conor Egan, Jonathan S. Nguyen-Van-Tam, Andrew Seaton, Clark D Russell, Thomas M Drake, Laura Merson, Jake Dunning, Daniel G. Wootton, Michelle Girvan, Annemarie B Docherty, Riinu Pius, Kenneth Baillie, Thushan I de Silva, Lance Turtle, Antonia Ho
Publikováno v:
SSRN Electronic Journal.
Background: Microbiological characterisation of co-infections and secondary infections in COVID-19 is lacking, while antimicrobial usage is high. We aimed to describe microbiologically-confirmed co-/secondary infections, and antimicrobial usage, in h
Autor:
Florencia A.T. Tettamanti, Cristina Venturini, Oliver T. Stirrup, José Afonso Guerra-Assuncao, Adela Alcolea-Medina, Angela H. Becket, Matthew Byott, Themoula Charalampous, Ana da Silva Filipe, Dan Frampton, Sharon Glaysher, Tabassum Khan, Raghavendran Kulasegara-Shylini, Beatrix Kele, Irene M. Monahan, Guy Mollett, Matthew D. Parker, Emanuela Pelosi, Paul Randell, Sunando Roy, Joshua F. Taylor, Sophie J. Weller, Eleri Wilson-Davies, Phillip Wade, Rachel Williams, COG-UK HOCI Variant Substudy Consortium, Andrew Copas, Teresa Cutino-Moguel, Nick Freemantle, Andrew C Hayward, Alison Holmes, Joseph Hughes Hughes, Tabitha W. Mahungu, Gaia Nebbia, Eleni Nastouli, David G. Partridge, Cassie F. Pope, James R. Price, Samuel C. Robson, Kordo Saeed, Gee Yen Shin, Thushan I. de Silva, Luke B. Snell, Emma C. Thomson, Adam A. Witney, Judith Breuer
Publikováno v:
SSRN Electronic Journal.
Background: Recently emerging SARS-CoV-2 variants have been associated with an increased rate of transmission within the community. Little is known about the impact their increased infectivity has on transmission within hospitals. Methods: We collect
Autor:
Rebecca Brown, Graham S. Ogg, Tao Dong, Julian C. Knight, Adrienn Angyal, Danning Dong, Lance Turtle, Guihai Liu, Zixi Yin, Susanna Dunachie, Thushan I de Silva, Yanchun Peng, Matthew Parker, Benjamin B Lindsey, Mala K. Maini, Alexander J. Mentzer, Xuan Yao, Dhruv R. Shah, Sarah Rowland-Jones
Publikováno v:
SSRN Electronic Journal.
We identify amino acid variants within dominant SARS-CoV-2 T-cell epitopes by interrogating global sequence data. Several variants within nucleocapsid and ORF3a epitopes have arisen independently in multiple lineages and result in loss of recognition
Autor:
Ed Clark, Ícaro Maia Santos de Castro, Rodrigo L T Ogava, Ya Jankey Jagne, David Jeffries, Hadijatou Sallah, Colin D. Bingle, Rebecca Ellis-Watson, André G. Costa-Martins, Benjamin B Lindsey, John S. Tregoning, Debby Bogaert, Thushan I de Silva, Edwin P. Armitage, Jose Ordovas-Montanes, Karim Mane, Beate Kampmann, Bankole Ahadzie, Helder I. Nakaya
Publikováno v:
SSRN Electronic Journal.
Rationale: In children lacking adaptive immunity to influenza, upper respiratory tract innate immune responses may be important and explain variability in viral shedding and disease outcome. Objectives: We used live attenuated influenza vaccine (LAIV
Autor:
Thushan I de Silva, Julia Edgar, Claire E. Turner, Alex Remmington, Luke R. Green, Samuel Haywood
Publikováno v:
Microbial Genomics. 7
The major human pathogen Streptococcus pyogenes shares an intimate evolutionary history with mobile genetic elements, which in many cases carry genes encoding bacterial virulence factors. During recent whole-genome sequencing of a longitudinal sample
Autor:
Thomas Marjot, Pamela Kearns, Ana Hughes, Thushan I de Silva, Michelle Willicombe, Sarah Pirrie, Amanda Kirkham, Georgina Meacham, Daniel Rea, Stefan Siebert, Sophie L. Irwin, Susanna Dunachie, Lance Turtle, Sophia Magwaro, Zixiang Lim, Carl S. Goodyear, David B. Thomas, Stavros I. Dimitriadis, Alex G. Richter, Jack Satsangi, Charlotte Gaskell, Iain B. McInnes, Peter Kelleher, Paul B. Miller, Eleanor Barnes, Sarah Bowden, Zay Win, Neil Basu, Paul Klenerman, Gordon Cook, Sam M. Murray
Publikováno v:
SSRN Electronic Journal.
SARS-COV-2 vaccines have been shown to be efficacious primarily in healthy volunteer populations and population level studies. Immune responses following SARS-CoV-2 vaccination are less well characterised in potentially immune vulnerable patient grou
Autor:
Abdoulie Bojang, Saikou Y. Bah, Edrissa Jallow, Bully Camara, Isatou Jagne, Thushan I de Silva, Christian Bottomley, Claire E. Turner, Umberto D'Alessandro, Abdul Karim Sesay, Elina Senghore, Anna Roca, Alexander J Keeley, Claire Oluwalana
BackgroundGroup A Streptococcus (GAS) is a major human pathogen and an important cause of maternal and neonatal sepsis.MethodsWe performed a posthoc analysis of a double-blind, placebo-controlled randomized-trial (ratio 1:1) carried out in The Gambia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a16779892194a10ae150f196706064bf
https://doi.org/10.1101/2020.12.04.20236653
https://doi.org/10.1101/2020.12.04.20236653
Autor:
Christina Dold, Helen A. Fletcher, John Frater, Alessandro Sette, Munir Pirmohamed, Mohammed K. Ali, Helen Brown, Andrew J. Pollard, Kareena Adair, Paul Thomson, Susanna Dunachie, M. Azim Ansari, Hossain Delowar Akhter, Kanoot Jaruthamsophon, Senthil Chinnakannan, Serat-E Ali, Donal T. Skelly, Panagiota Zacharopoulou, Narayan Ramamurthy, Timothy Donnison, Philippa C Matthews, David W Eyre, Dean J. Naisbitt, Carl-Philipp Hackstein, Nicholas T.Y. Lim, Alexander J. Mentzer, James T. Grist, Patpong Rongkard, Lizzie Stafford, Lance Turtle, Sarah Rowland-Jones, Carolina V. Arancibia-Cárcamo, Emily Adland, M Pace, Christopher P. Conlon, Oxford Protective T cell Immunology for Covid (Optic) Clinical team, Wenqin Li, Katie Jeffrey, Gavin R. Screaton, Thushan I de Silva, Amy Flaxman, Paul Klenerman, Joshua Gardner, Peter J. M. Openshaw, Teresa Lambe, Oliver Sampson, Eleanor Barnes, Craig Thompson, Vinicius A Vieira, Lian Lee, Catherine de Lara, Daniela Weiskopf, Philip J. R. Goulder, B Kronsteiner, Tao Dong Dong, Ryan S Thwaites, Anthony Brown, Adrienn Angyal, Graham S. Ogg, Ane Ogbe, Shona C Moore, Monday O. Ogese
A major issue in identification of protective T cell responses against SARS-CoV-2 lies in distinguishing people infected with SARS-CoV-2 from those with cross-reactive immunity generated by exposure to other coronaviruses. We characterised SARS-CoV-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::022f779a35ddf73ff3bd0f70f0cad194
https://doi.org/10.1101/2020.09.28.20202929
https://doi.org/10.1101/2020.09.28.20202929
Autor:
André G. Costa-Martins, Karim Mane, Benjamin B. Lindsey, Rodrigo L.T. Ogava, Ícaro Castro, Ya Jankey Jagne, Hadijatou J. Sallah, Edwin P. Armitage, Sheikh Jarju, Bankole Ahadzie, Rebecca Ellis-Watson, John S. Tregoning, Colin D. Bingle, Debby Bogaert, Ed Clarke, Jose Ordovas-Montanes, David Jeffries, Beate Kampmann, Helder I. Nakaya, Thushan I. de Silva
Publikováno v:
Cell Reports Medicine
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Summary In children lacking influenza-specific adaptive immunity, upper respiratory tract innate immune responses may influence viral replication and disease outcome. We use trivalent live attenuated influenza vaccine (LAIV) as a surrogate challenge