Zobrazeno 61 - 70
of 112
pro vyhledávání: '"Thurl E. Harris"'
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 6, Pp 1662-1677 (2013)
Peroxisome proliferator-activated receptor α (PPARα) and PPARγ coactivator 1α (PGC-1α) are crucial transcriptional regulators for genes involved in FA oxidation. Lipin-1 is essential for this increased capacity for β-oxidation in fasted livers,
Autor:
Karim Nadra, Mayurranjan S. Mitra, Roman Chrast, Kari T. Chambers, Xiong Su, Hongmei Ren, Zhouji Chen, Brian N. Finck, Samuel Klein, Andrew J. Morris, Thurl E. Harris, Angela M. Hall
Publikováno v:
Proceedings of the National Academy of Sciences. 110:642-647
Lipin 1 is a coregulator of DNA-bound transcription factors and a phosphatidic acid (PA) phosphatase (PAP) enzyme that catalyzes a critical step in the synthesis of glycerophospholipids. Lipin 1 is highly expressed in adipocytes, and constitutive los
Autor:
Damian P Kotevski, Zengying Wu, Weiqin Chen, Yuan Tian, Ivan Lukmantara, Yanfei Qi, Hongyuan Yang, Mona Lei, Daniel E. Cooper, Robert G. Parton, George Liu, Martin Pagac, Thurl E. Harris, Zhonghua Liu, Xun Huang, Pawel Sadowski, Salome Boroda, Charles Ferguson, Hoi Yin Mak, Ximing Du, Rosalind A. Coleman
Publikováno v:
Cell reports
Cell Reports, Vol 17, Iss 6, Pp 1546-1559 (2016)
Cell Reports, Vol 17, Iss 6, Pp 1546-1559 (2016)
SUMMARY Berardinelli-Seip congenital lipodystrophy 2 (BSCL2) is caused by loss-of-function mutations in SEIPIN, a protein implicated in both adipogenesis and lipid droplet expansion but whose molecular function remains obscure. Here, we identify phys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7641adc6dc993bfd0e544a275463829
Autor:
Thurl E. Harris, Di Wu, Jeffrey Shabanowitz, Zheng Fu, Jessica R. Chapman, Donald F. Hunt, Lifu Wang
Publikováno v:
Journal of Biological Chemistry. 287:12510-12519
Intestinal cell kinase (ICK), named after its cloning origin, the intestine, is actually a ubiquitously expressed and highly conserved serine/threonine protein kinase. Recently we reported that ICK supports cell proliferation and G(1) cell cycle prog
Autor:
Isabel Gonzalez, Carol Burdsal, Jennifer L. Sloan, Ann Sutherland, Sela Mager, Thurl E. Harris, Patrick M. Martin
Publikováno v:
Developmental Biology. 361(2):286-300
Uterine implantation is a critical element of mammalian reproduction and is a tightly and highly coordinated event. An intricate and reciprocal uterine-embryo dialog exists to synchronize uterine receptivity with the concomitant activation of the bla
Autor:
Cláudia F. Santos, Nilberto R.F. Nascimento, Robert M. Carey, Nancy L. Howell, Thurl E. Harris, Brandon A. Kemp, John J Gildea
Publikováno v:
Hypertension. 58:107-113
cGMP functions as an extracellular (paracrine) messenger acting at the renal proximal tubule and is an important modulator of pressure-natriuresis (P-N). The signaling pathway activated by cGMP in the tubule cell basolateral membrane remains unknown.
Autor:
Brian N. Finck, Thurl E. Harris
Publikováno v:
Trends in Endocrinology & Metabolism. 22:226-233
Lipin family proteins are emerging as crucial regulators of lipid metabolism. In triglyceride synthesis, lipins act as lipid phosphatase enzymes at the endoplasmic reticular membrane, catalyzing the dephosphorylation of phosphatidic acid to form diac
Autor:
Hwi Jin Ko, Thurl E. Harris, John C. Lawrence, Jason K. Kim, Mark A. Magnuson, Susanna R. Keller, Anil Kumar, Dae Young Jung
Publikováno v:
Diabetes
OBJECTIVE Rictor is an essential component of mammalian target of rapamycin (mTOR) complex (mTORC) 2, a kinase that phosphorylates and activates Akt, an insulin signaling intermediary that regulates glucose and lipid metabolism in adipose tissue, ske
Autor:
Thurl E. Harris, Stephen B. G. Abbott, Gavin H. West, Ruth L. Stornetta, Patrice G. Guyenet, Michal G. Fortuna, Seth D. DePuy
Publikováno v:
The Journal of Neuroscience. 29:5806-5819
The retrotrapezoid “nucleus” (RTN), located in the rostral ventrolateral medullary reticular formation, contains a bilateral cluster of ∼1000 glutamatergic noncatecholaminergic Phox2b-expressing propriobulbar neurons that are activated by CO2in
Autor:
Zhouji Chen, Matthew C. Gropler, John C. Lawrence, Jin Norris, Brian N. Finck, Thurl E. Harris
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 28:1738-1744
Objective— Lipin 1 controls fatty acid metabolism in the nucleus as a transcriptional regulator and in the cytosol as an enzyme catalyzing the penultimate step in phosphoglycerol triacylglyceride (TAG) synthesis. We sought to evaluate the effects o