Zobrazeno 11 - 20
of 112
pro vyhledávání: '"Thurl E. Harris"'
Autor:
Martin Pagac, Daniel E. Cooper, Yanfei Qi, Ivan E. Lukmantara, Hoi Yin Mak, Zengying Wu, Yuan Tian, Zhonghua Liu, Mona Lei, Ximing Du, Charles Ferguson, Damian Kotevski, Pawel Sadowski, Weiqin Chen, Salome Boroda, Thurl E. Harris, George Liu, Robert G. Parton, Xun Huang, Rosalind A. Coleman, Hongyuan Yang
Publikováno v:
Cell Reports, Vol 17, Iss 6, Pp 1546-1559 (2016)
Berardinelli-Seip congenital lipodystrophy 2 (BSCL2) is caused by loss-of-function mutations in SEIPIN, a protein implicated in both adipogenesis and lipid droplet expansion but whose molecular function remains obscure. Here, we identify physical and
Externí odkaz:
https://doaj.org/article/bba742076e6a484f95bec3c954f64b30
Autor:
Samantha E. Adamson, Akshaya K. Meher, Yu-hsin Chiu, Joanna K. Sandilos, Nathaniel P. Oberholtzer, Natalie N. Walker, Stefan R. Hargett, Scott A. Seaman, Shayn M. Peirce-Cottler, Brant E. Isakson, Coleen A. McNamara, Susanna R. Keller, Thurl E. Harris, Douglas A. Bayliss, Norbert Leitinger
Publikováno v:
Molecular Metabolism, Vol 4, Iss 9, Pp 610-618 (2015)
Objective: Defective glucose uptake in adipocytes leads to impaired metabolic homeostasis and insulin resistance, hallmarks of type 2 diabetes. Extracellular ATP-derived nucleotides and nucleosides are important regulators of adipocyte function, but
Externí odkaz:
https://doaj.org/article/9b68597c47644aa7ac673be018d95003
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 6, Pp 1662-1677 (2013)
Peroxisome proliferator-activated receptor α (PPARα) and PPARγ coactivator 1α (PGC-1α) are crucial transcriptional regulators for genes involved in FA oxidation. Lipin-1 is essential for this increased capacity for β-oxidation in fasted livers,
Externí odkaz:
https://doaj.org/article/2414c553a6794a3eb23614eeb2120fe6
Autor:
Jacob H. Murray, Ariel L. Burgio, Martina Beretta, Stefan R. Hargett, Thurl E. Harris, Ellen Olzomer, R. Justin Grams, Christopher J. Garcia, Catherine Li, Joseph M. Salamoun, Kyle L. Hoehn, Webster L. Santos
Publikováno v:
Journal of Medicinal Chemistry. 66:3876-3895
Autor:
Roberto Mendez, Minhaj Shaikh, Michael C. Lemke, Kun Yuan, Adam H. Libby, Dina L. Bai, Mark M. Ross, Thurl E. Harris, Ku-Lung Hsu
Publikováno v:
RSC Chemical Biology.
We provide a family-wide assessment of accessible sites for covalent targeting that combined with AlphaFold revealed predicted small molecule binding pockets for guiding future inhibitor development of the DGK superfamily.
Autor:
Qianyi Yang, Jameson Hinkle, Jordan N. Reed, Redouane Aherrahrou, Zhiwen Xu, Thurl E. Harris, Erin J. Stephenson, Kiran Musunuru, Susanna R. Keller, Mete Civelek
Publikováno v:
Diabetes
Genome-wide association studies identified single nucleotide polymorphisms on chromosome 7 upstream of KLF14 to be associated with metabolic syndrome traits and increased risk for Type 2 Diabetes (T2D). The associations were more significant in women
Autor:
Scott Yeudall, Clint M. Upchurch, Philip V. Seegren, Caitlin M. Pavelec, Jan Greulich, Michael C. Lemke, Thurl E. Harris, Bimal N. Desai, Kyle L. Hoehn, Norbert Leitinger
Publikováno v:
Science Advances. 8
Acetyl-CoA carboxylase (ACC) regulates lipid synthesis; however, its role in inflammatory regulation in macrophages remains unclear. We generated mice that are deficient in both ACC isoforms in myeloid cells. ACC deficiency altered the lipidomic, tra
Autor:
Katharina Bottermann, Lisa Kalfhues, Rianne Nederlof, Anne Hemmers, Lucia M. Leitner, Vici Oenarto, Jana Nemmer, Mirjam Pfeffer, Vidisha Raje, Rene Deenen, Patrick Petzsch, Heba Zabri, Karl Köhrer, Andreas S. Reichert, Maria Grandoch, Jens W. Fischer, Diran Herebian, Johannes Stegbauer, Thurl E. Harris, Axel Gödecke
Publikováno v:
Basic Research in Cardiology. 117
Although p38 MAP Kinase α (p38 MAPKα) is generally accepted to play a central role in the cardiac stress response, to date its function in maladaptive cardiac hypertrophy is still not unambiguously defined. To induce a pathological type of cardiac
Autor:
Ku-Lung Hsu, Heather A. Ferris, Jeffrey W. Brulet, Mitchell E. Granade, Thurl E. Harris, Tao Huang, Seyyedmohsen Hosseinibarkooie, Adam L. Borne
Publikováno v:
Chemical Science
Sulfonyl-triazoles are a new class of electrophiles that mediate covalent reaction with tyrosine residues on proteins through sulfur-triazole exchange (SuTEx) chemistry. Recent studies demonstrate the broad utility and tunability of SuTEx chemistry f
Publikováno v:
Journal of Cardiovascular Pharmacology and Therapeutics. 26:289-297
The pathological role of adipose derived fatty acids following myocardial infarction has long been hypothesized. However, most methods for reducing adipocyte lipolysis have significant non-adipose effects. Atglistatin, a direct inhibitor of the initi