Zobrazeno 11 - 20
of 167
pro vyhledávání: '"Takashi Umehara"'
Cutting the ovarian surface improves the responsiveness to exogenous hormonal treatment in aged mice
Autor:
Takashi Umehara, Nao Urabe, Toshiki Obata, Takashi Yamaguchi, Atsushi Tanaka, Masayuki Shimada
Publikováno v:
Reproductive Medicine and Biology, Vol 19, Iss 4, Pp 415-424 (2020)
Abstract Purpose Ovarian vascular abnormality and ovarian fibrosis are observed in the low responder patients and aging mice. Vascularization and fibrosis are regulated by injury‐repair system, such as wound. Thus, in this study, the authors tried
Externí odkaz:
https://doaj.org/article/b0b48e57839f408ebe79d9e040948f5e
Publikováno v:
Cancers, Vol 14, Iss 21, p 5404 (2022)
Eukaryotic gene expression is regulated through chromatin conformation, in which enhancers and promoters physically interact (E–P interactions). How such chromatin-mediated E–P interactions affect gene expression is not yet fully understood, but
Externí odkaz:
https://doaj.org/article/b2dc6d0cef53464a865a7c63c13e33f1
Autor:
Takashi Umehara
Publikováno v:
Epigenomes, Vol 6, Iss 3, p 18 (2022)
Epigenomic modifications are unique in the type and amount of chemical modification at each chromosomal location, can vary from cell to cell, and can be externally modulated by small molecules. In recent years, genome-wide epigenomic modifications ha
Externí odkaz:
https://doaj.org/article/c9e7a913c4674a79a397fd18438931fb
Autor:
Takeshi Tsusaka, Masaki Kikuchi, Tadahiro Shimazu, Takehiro Suzuki, Yoshihiro Sohtome, Mai Akakabe, Mikiko Sodeoka, Naoshi Dohmae, Takashi Umehara, Yoichi Shinkai
Publikováno v:
Epigenetics & Chromatin, Vol 11, Iss 1, Pp 1-16 (2018)
Abstract Background G9a and the related enzyme GLP were originally identified as histone lysine methyltransferases and then shown to also methylate several other non-histone proteins. Results Here, we performed a comprehensive screen to identify thei
Externí odkaz:
https://doaj.org/article/1cc73731d93540978a8329f7d39f5860
Autor:
Lusy Handoko, Bogumil Kaczkowski, Chung-Chau Hon, Marina Lizio, Masatoshi Wakamori, Takayoshi Matsuda, Takuhiro Ito, Prashanti Jeyamohan, Yuko Sato, Kensaku Sakamoto, Shigeyuki Yokoyama, Hiroshi Kimura, Aki Minoda, Takashi Umehara
Publikováno v:
Epigenetics, Vol 13, Iss 4, Pp 410-431 (2018)
The bromodomain and extra-terminal domain (BET) proteins are promising drug targets for cancer and immune diseases. However, BET inhibition effects have been studied more in the context of bromodomain-containing protein 4 (BRD4) than BRD2, and the BE
Externí odkaz:
https://doaj.org/article/a5a3e24b8e2b44a8ae4456359d3ec093
Autor:
Hideaki Niwa, Takashi Umehara
Publikováno v:
Epigenetics, Vol 12, Iss 5, Pp 340-352 (2017)
Until 2004, many researchers believed that protein methylation in eukaryotic cells was an irreversible reaction. However, the discovery of lysine-specific demethylase 1 in 2004 drastically changed this view and the concept of chromatin regulation. Si
Externí odkaz:
https://doaj.org/article/579491c57f574614a496f2ba49e8c47b
Publikováno v:
PLoS Biology, Vol 17, Iss 8, p e3000398 (2019)
In most mammals, the male to female sex ratio of offspring is about 50% because half of the sperm contain either the Y chromosome or X chromosome. In mice, the Y chromosome encodes fewer than 700 genes, whereas the X chromosome encodes over 3,000 gen
Externí odkaz:
https://doaj.org/article/b39e68f475b7454bb0b0536af26d446f
Autor:
Zhendong Zhu, Takashi Umehara, Tetsuji Okazaki, Masaaki Goto, Yoko Fujita, S. A. Masudul Hoque, Tomoko Kawai, Wenxian Zeng, Masayuki Shimada
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Sperm motility patterns are continuously changed after ejaculation to fertilization in the female tract. Hyperactivated motility is induced with high glucose medium in vitro or the oviduct fluids in vivo, whereas sperm maintain linear motility in the
Externí odkaz:
https://doaj.org/article/4404b514550e4e2ba650d6aa6a5e6907
Autor:
Yosuke Yoneyama, Peter Lanzerstorfer, Hideaki Niwa, Takashi Umehara, Takashi Shibano, Shigeyuki Yokoyama, Kazuhiro Chida, Julian Weghuber, Fumihiko Hakuno, Shin-Ichiro Takahashi
Publikováno v:
eLife, Vol 7 (2018)
Insulin-like growth factor-I receptor (IGF-IR) preferentially regulates the long-term IGF activities including growth and metabolism. Kinetics of ligand-dependent IGF-IR endocytosis determines how IGF induces such downstream signaling outputs. Here,
Externí odkaz:
https://doaj.org/article/388bab19741b4c1cb10063dd56c18698
Autor:
Hiroya Kitasaka, Tomoko Kawai, S A Masudul Hoque, Takashi Umehara, Youko Fujita, Masayuki Shimada
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0192458 (2018)
It has been known that EGF-like factor secreted from LH-stimulated granuloma cells acts on granulosa cells and cumulus cells to induce ovulation process. Granulosa cells are changed the morphology with differentiating cell functions to produce proges
Externí odkaz:
https://doaj.org/article/c60347316a3344dd81b9dbcb029a679d