Zobrazeno 1 - 10
of 118
pro vyhledávání: '"Takahiko Shiina"'
Autor:
Takahiko Shiina, Yuji Suzuki, Kazuhiro Horii, Tomoya Sawamura, Natsufu Yuki, Yuuki Horii, Yasutake Shimizu
Publikováno v:
Journal of Physiological Sciences, Vol 74, Iss 1, Pp 1-12 (2024)
Abstract Purines such as ATP are regulatory transmitters in motility of the gastrointestinal tract. The aims of this study were to propose functional roles of purinergic regulation of esophageal motility. An isolated segment of the rat esophagus was
Externí odkaz:
https://doaj.org/article/0ce033dac2624bf8b2bae08339892a12
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 4, p 1985 (2024)
The tunica muscularis of mammalian esophagi is composed of striated muscle and smooth muscle. Contraction of the esophageal striated muscle portion is mainly controlled by cholinergic neurons. On the other hand, smooth muscle contraction and relaxati
Externí odkaz:
https://doaj.org/article/1fbcd22c955d4e07a95e2f94e782e460
Autor:
Hiromi H. Ueda, Kiyotada Naitou, Hiroyuki Nakamori, Kazuhiro Horii, Takahiko Shiina, Tatsunori Masatani, Mitsuya Shiraishi, Yasutake Shimizu
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract The central nervous system is involved in regulation of defaecation. It is generally considered that supraspinal regions control the spinal defaecation centre. However, signal transmission from supraspinal regions to the spinal defaecation c
Externí odkaz:
https://doaj.org/article/3364da7d49cc4cee83da194773133382
Autor:
Takahiko Shiina, Yasutake Shimizu
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 20, p 7599 (2020)
Multiple mRNA isoforms are often generated during processing such as alternative splicing of precursor mRNAs (pre-mRNA), resulting in a diversity of generated proteins. Alternative splicing is an essential mechanism for the functional complexity of e
Externí odkaz:
https://doaj.org/article/84a6d4f3d7e6462397c4bbb1b42d2b73
Autor:
Tomoya Sawamura, Natsufu Yuki, Kazuhiro Horii, Kiyotada Naitou, Hiroshi Yamaguchi, Akihiro Yamanaka, Takahiko Shiina, Yasutake Shimizu
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 324:G466-G475
The A11 region and the raphe nuclei, constituting descending pain inhibitory pathways, are related to both intracolonic noxious stimuli-induced colorectal motility and stress-induced defecation. Our findings may provide an explanation for the concurr
Autor:
Tomoya Sawamura, Natsufu Yuki, Kanae Aoki, Kazuhiro Horii, Yuuki Horii, Kiyotada Naitou, Shumpei Tsukamoto, Takahiko Shiina, Yasutake Shimizu
Publikováno v:
American Journal of Physiology: Gastrointestinal & Liver Physiology; Feb2024, Vol. 326 Issue 2, pG195-G204, 10p
Publikováno v:
Journal of Smooth Muscle Research. 59:28-33
Autor:
Kazuhiro Horii, Tomoya Sawamura, Ayaka Onishi, Natsufu Yuki, Kiyotada Naitou, Takahiko Shiina, Yasutake Shimizu
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 323:G1-G8
Our recent studies have shown that noxious stimuli in the colorectum enhance colorectal motility via the brain and spinal defecation centers in male rats. In female rats, however, noxious stimuli have no effect on colorectal motility. The purpose of
Publikováno v:
Biomedical Research. 43:53-57
Autor:
Kiyotada Naitou, Honoka Iwashita, Hiromi H. Ueda, Mitsuya Shiraishi, Yoshikazu Fujimoto, Kazuhiro Horii, Tomoya Sawamura, Takahiko Shiina, Yasutake Shimizu
Publikováno v:
American journal of physiology. Gastrointestinal and liver physiology. 323(1)
Noxious stimuli on the colorectum cause colorectal contractions through activation of descending monoaminergic pathways projecting from the supraspinal defecation center to the spinal defecation center. Since it is known that substance P is involved