Zobrazeno 31 - 40
of 91
pro vyhledávání: '"Susanna M. Hofmann"'
Autor:
Aparna Neelakandhan, Matthias H. Tschöp, Mostafa Bakhti, Katrin Fischer, Aimée Bastidas-Ponce, Sophie Tritschler, Miguel A. Sánchez-Garrido, Anika Böttcher, Stephan Sachs, Erik Bader, Susanna M. Hofmann, Sara S. Roscioni, Fabian J. Theis, Siegfried Ussar, Brian Finan, Heiko Lickert, Annette Feuchtinger, Sigrid Jall, Burcak Yesildag, Richard D. DiMarchi, Marta Tarquis-Medina, Alexandra Harger, Maximilian Kleinert, Marion Cornu, Christine B. Jensen, Bin Yang, Timo D. Müller
Publikováno v:
Nat. Metab. 2, 192-209 (2020)
Sachs, S, Bastidas-Ponce, A, Tritschler, S, Bakhti, M, Böttcher, A, Sánchez-Garrido, M A, Tarquis-Medina, M, Kleinert, M, Fischer, K, Jall, S, Harger, A, Bader, E, Roscioni, S, Ussar, S, Feuchtinger, A, Yesildag, B, Neelakandhan, A, Jensen, C B, Cornu, M, Yang, B, Finan, B, DiMarchi, R D, Tschöp, M H, Theis, F J, Hofmann, S M, Müller, T D & Lickert, H 2020, ' Targeted pharmacological therapy restores β-cell function for diabetes remission ', Nature Metabolism, vol. 2, no. 2, pp. 192-209 . https://doi.org/10.1038/s42255-020-0171-3
Nature Metabolism
Sachs, S, Bastidas-Ponce, A, Tritschler, S, Bakhti, M, Böttcher, A, Sánchez-Garrido, M A, Tarquis-Medina, M, Kleinert, M, Fischer, K, Jall, S, Harger, A, Bader, E, Roscioni, S, Ussar, S, Feuchtinger, A, Yesildag, B, Neelakandhan, A, Jensen, C B, Cornu, M, Yang, B, Finan, B, DiMarchi, R D, Tschöp, M H, Theis, F J, Hofmann, S M, Müller, T D & Lickert, H 2020, ' Targeted pharmacological therapy restores β-cell function for diabetes remission ', Nature Metabolism, vol. 2, no. 2, pp. 192-209 . https://doi.org/10.1038/s42255-020-0171-3
Nature Metabolism
Dedifferentiation of insulin-secreting β cells in the islets of Langerhans has been proposed to be a major mechanism of β-cell dysfunction. Whether dedifferentiated β cells can be targeted by pharmacological intervention for diabetes remission, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::326ff9bec73d13a151285ddd1708c077
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=58501
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=58501
Autor:
Michael Ristow, Mostafa Bakhti, Peter Huypens, Timo D. Müller, Mark L. Heiman, Susanna M. Hofmann, Alan D. Cherrington, Heiko Lickert, Martin Hrabé de Angelis, Stephen C. Woods, Annette Schürmann, Johannes Beckers, Mary Courtney Moore, Peter J. Havel, Christoffer Clemmensen, Simone Renner, Eckhard Wolf, Martin Klingenspor, Matthias H. Tschöp, Maximilian Kleinert
Publikováno v:
Kleinert, Maximilian; Clemmensen, Christoffer; Hofmann, Susanna M; Moore, Mary C; Renner, Simone; Woods, Stephen C; et al.(2018). Animal models of obesity and diabetes mellitus.. Nature reviews. Endocrinology, 14(3), 140-162. doi: 10.1038/nrendo.2017.161. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/3z3879vp
Nature reviews. Endocrinology, vol 14, iss 3
Nature reviews. Endocrinology, vol 14, iss 3
More than one-third of the worldwide population is overweight or obese and therefore at risk of developing type 2 diabetes mellitus. In order to mitigate this pandemic, safer and more potent therapeutics are urgently required. This necessitates the c
Autor:
Andries Kalsbeek, Nikita L. Korpel, Susanna M. Hofmann, Irina Milanova, Yuanqing Gao, Andrés Vidal-Itriago, Robby Zachariah Tom, Martin J. T. Kalsbeek, Chun-Xia Yi
Publikováno v:
Mol. Metab. 7, 155-160 (2017)
Molecular Metabolism, 7, 155-160. Elsevier B.V.
Molecular metabolism, 7, 155-160. Elsevier GmbH
Molecular Metabolism, Vol 7, Iss, Pp 155-160 (2018)
Molecular Metabolism, 7, 155-160. Elsevier B.V.
Molecular metabolism, 7, 155-160. Elsevier GmbH
Molecular Metabolism, Vol 7, Iss, Pp 155-160 (2018)
Objective: Leptin is a cytokine produced by adipose tissue that acts mainly on the hypothalamus to regulate appetite and energy homeostasis. Previous studies revealed that the leptin receptor is expressed not only in neurons, but also in glial cells.
Autor:
Pamela Fischer-Posovszky, Stephan Sachs, Lucia Berti, Ellen Walheim, Martin Wabitsch, Martin Hrabě de Angelis, Daniel Tews, Bernhard Raedle, Susanna M. Hofmann, Harald Staiger, Martin Jastroch, Gabi Kastenmüller, Matthias H. Tschöp, Michaela Keuper
Publikováno v:
Molecular Metabolism, Vol 6, Iss 10, Pp 1226-1239 (2017)
Molecular Metabolism
Mol. Metab. 6, 1226-1239 (2017)
Molecular Metabolism
Mol. Metab. 6, 1226-1239 (2017)
Objective Obesity-associated WAT inflammation is characterized by the accumulation and local activation of macrophages (MΦs), and recent data from mouse studies suggest that macrophages are modifiers of adipocyte energy metabolism and mitochondrial
Autor:
Martin Irmler, Carola W. Meyer, I P Fischer, M. H. Tschöp, M. Hrabě de Angelis, Frauke Neff, Johannes Beckers, Siegfried Ussar, Stephan Sachs, Susanna M. Hofmann
Publikováno v:
Int. J. Obes. 42, 507-517 (2018)
International Journal of Obesity (2005)
International Journal of Obesity (2005)
Background/Objectives: Dieting is a popular yet often ineffective way to lower body weight, as the majority of people regain most of their pre-dieting weights in a relatively short time. The underlying molecular mechanisms driving weight regain and t
Autor:
Arthur J. Verhoeven, Yuanqing Gao, Clarita Layritz, Jie Yan, Andrés Vidal-Itriago, Thomas O. Eichmann, Cristina García-Cáceres, Robert H. Eckel, Frédéric M. Vaz, Nicole N. van der Wel, Riekelt H. Houtkooper, Robby Zachariah Tom, Chun-Xia Yi, Susanna M. Hofmann, Andries Kalsbeek, Martin J. T. Kalsbeek
Publikováno v:
Cell Rep. 20, 3034-3042 (2017)
Cell reports, 20(13), 3034-3042. Cell Press
Cell Reports, 20(13), 3034-3042. Cell Press
Cell Reports, Vol 20, Iss 13, Pp 3034-3042 (2017)
Cell reports, 20(13), 3034-3042. Cell Press
Cell Reports, 20(13), 3034-3042. Cell Press
Cell Reports, Vol 20, Iss 13, Pp 3034-3042 (2017)
Consumption of a hypercaloric diet upregulates microglial innate immune reactivity along with a higher expression of lipoprotein lipase (Lpl) within the reactive microglia in the mouse brain. Here, we show that knockdown of the Lpl gene specifically
Autor:
Timo D. Müller, Matthias H. Tschöp, Richard D. DiMarchi, Brian Finan, Sigrid Jall, Frauke Neff, Christoffer Clemmensen, Stephan Sachs, Susanna M. Hofmann
Publikováno v:
Molecular Metabolism
Mol. Metab. 6, 440-446 (2017)
Molecular Metabolism, Vol 6, Iss 5, Pp 440-446 (2017)
Mol. Metab. 6, 440-446 (2017)
Molecular Metabolism, Vol 6, Iss 5, Pp 440-446 (2017)
Objective Obesity is a major health threat that affects men and women equally. Despite this fact, weight-loss potential of pharmacotherapies is typically first evaluated in male mouse models of diet-induced obesity (DIO). To address this disparity we
Plasma proteome profiling discovers novel proteins associated with non-alcoholic fatty liver disease
Autor:
Peter V. Treit, Nicolai J. Wewer Albrechtsen, Stephan Sachs, Kerstin Stemmer, Jens J. Holst, Anders Ellekær Junker, Matthias H. Tschöp, Alberto Santos, Tina Vilsbøll, Filip K. Knop, Timo D. Müller, Susanna M. Hofmann, Lili Niu, Philipp E. Geyer, Sophia Doll, Matthias Mann, Lise Lotte Gluud
Publikováno v:
Mol. Syst. Biol. 15:e8793 (2019)
Molecular Systems Biology
BASE-Bielefeld Academic Search Engine
Niu, L, Geyer, P E, Albrechtsen, N J W, Gluud, L L, Santos, A, Doll, S, Treit, P V, Holst, J J, Knop, F K, Vilsbøll, T, Junker, A, Sachs, S, Stemmer, K, Müller, T D, Tschöp, M H, Hofmann, S M & Mann, M 2019, ' Plasma proteome profiling discovers novel proteins associated with non-alcoholic fatty liver disease ', Molecular Systems Biology, vol. 15, e8793 . https://doi.org/10.15252/msb.20188793
Molecular Systems Biology
BASE-Bielefeld Academic Search Engine
Niu, L, Geyer, P E, Albrechtsen, N J W, Gluud, L L, Santos, A, Doll, S, Treit, P V, Holst, J J, Knop, F K, Vilsbøll, T, Junker, A, Sachs, S, Stemmer, K, Müller, T D, Tschöp, M H, Hofmann, S M & Mann, M 2019, ' Plasma proteome profiling discovers novel proteins associated with non-alcoholic fatty liver disease ', Molecular Systems Biology, vol. 15, e8793 . https://doi.org/10.15252/msb.20188793
Non‐alcoholic fatty liver disease (NAFLD) affects 25% of the population and can progress to cirrhosis with limited treatment options. As the liver secretes most of the blood plasma proteins, liver disease may affect the plasma proteome. Plasma prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9e2972462557b1d88f6da1f82359f42
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=55606
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=55606
Autor:
Christoffer, Clemmensen, Brian, Finan, Timo D, Müller, Richard D, DiMarchi, Matthias H, Tschöp, Susanna M, Hofmann
Publikováno v:
Nature reviews. Endocrinology. 15(2)
Obesity and its comorbidities, such as type 2 diabetes mellitus and cardiovascular disease, constitute growing challenges for public health and economies globally. The available treatment options for these metabolic disorders cannot reverse the disea
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 5, Iss 5, Pp 321-327 (2016)
Mol. Metab. 5, 321-327 (2016)
Molecular Metabolism, Vol 5, Iss 5, Pp 321-327 (2016)
Mol. Metab. 5, 321-327 (2016)
Background: High density lipoproteins (HDLs) are thought to be atheroprotective and to reduce the risk of cardiovascular disease (CVD). Besides their antioxidant, antithrombotic, anti-inflammatory, anti-apoptotic properties in the vasculature, HDLs a