Zobrazeno 51 - 60
of 646
pro vyhledávání: '"Susan M Domchek"'
Autor:
Angela M. DeMichele, Peter J. O'Dwyer, Kevin R. Fox, Susan M. Domchek, Angela R. Bradbury, Maryann Gallagher, Colleen Redlinger, Jessica Burrell, Mark Rosen, Priti Lal, Michael Feldman, Andrea Troxel, Nicholas P. McAndrew, Amy S. Clark
KM Curves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22da2a0269c9cb62f5e3a013987edfe6
https://doi.org/10.1158/1078-0432.22471710
https://doi.org/10.1158/1078-0432.22471710
Autor:
Jirong Long, Wei Zheng, Paul D.P. Pharoah, Thomas A. Sellers, Georgia Chenevix-Trench, Ellen L. Goode, Andrew Berchuck, Antonis C. Antoniou, Simon A. Gayther, Kristin K. Zorn, Drakoulis Yannoukakos, Anna H. Wu, Alicja Wolk, Emily White, Nicolas Wentzensen, Jeffrey N. Weitzel, Penelope M. Webb, Digna Velez Edwards, Ana Vega, Adriaan Vanderstichele, Elizabeth J. van Rensburg, Shelley S. Tworoger, Nadine Tung, Antonia Trichopoulou, Amanda E. Toland, Marc Tischkowitz, Mads Thomassen, Soo H. Teo, Manuel R. Teixeira, Anthony J. Swerdlow, Rebecca Sutphen, Amanda B. Spurdle, Melissa C. Southey, Honglin Song, Christian F. Singer, Jacques Simard, Weiva Sieh, Priyanka Sharma, Veronica W. Setiawan, Rita K. Schmutzler, Dale P. Sandler, Iwona K. Rzepecka, Mary Anne Rossing, Matti A. Rookus, Isabelle Romieu, Cristina Rodríguez-Antona, Gustavo C. Rodriguez, Harvey Risch, Gad Rennert, Susan J. Ramus, Miquel Angel Pujana, Catherine M. Phelan, Paolo Peterlongo, Tanja Pejovic, Petra H.M. Peeters, Michael T. Parsons, Sue K. Park, Ana Osorio, Håkan Olsson, Sara H. Olson, Olufunmilayo I. Olopade, Edith Olah, Kenneth Offit, Robert L. Nussbaum, Liene Nikitina-Zake, Finn C. Nielsen, Heli Nevanlinna, Susan L. Neuhausen, Marco Montagna, Francesmary Modugno, Melissa A. Merritt, Iain A. McNeish, Lesley McGuffog, Taymaa May, Amalia Mattiello, Douglas A. Levine, Fabienne Lesueur, Goska Leslie, Nhu D. Le, Ava Kwong, Susanne K. Kjaer, Lambertus A. Kiemeney, Linda E. Kelemen, Beth Y. Karlan, Paul James, Anna Jakubowska, Claudine Isaacs, Evgeny N. Imyanitov, David G. Huntsman, Peter J. Hulick, Antoinette Hollestelle, Claus K. Høgdall, Michelle A.T. Hildebrandt, Florian Heitz, Ute Hamann, Jacek Gronwald, Mark H. Greene, Marc T. Goodman, David E. Goldgar, Andrew K. Godwin, Graham G. Giles, Judy Garber, Patricia A. Ganz, Eitan Friedman, George Fountzilas, Renée T. Fortner, Peter A. Fasching, Diana M. Eccles, Douglas F. Easton, Thilo Dörk, Susan M. Domchek, Orland Diez, Joe Dennis, Anna deFazio, Mary B. Daly, Daniel W. Cramer, Fergus J. Couch, Kathleen B.M. Claes, Jenny Chang-Claude, Ian Campbell, Maria A. Caligo, Trinidad Caldes, Ralf Butzow, James Brenton, Line Bjorge, Javier Benitez, Daniel R. Barnes, Rosa B. Barkardottir, Elisa V. Bandera, Banu K. Arun, Hoda Anton-Culver, Irene L. Andrulis, Kirsten B. Moysich, Jamie K. Teer, Brett M. Reid, Jennifer B. Permuth, Yian A. Chen, Hae Kyung Im, Joellen M. Schildkraut, Bingshan Li, Xingyi Guo, Lang Wu, Alicia Beeghly-Fadiel, Yingchang Lu
Large-scale genome-wide association studies (GWAS) have identified approximately 35 loci associated with epithelial ovarian cancer (EOC) risk. The majority of GWAS-identified disease susceptibility variants are located in noncoding regions, and causa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e690127f98de38e275c696f108a3156
https://doi.org/10.1158/0008-5472.c.6510431.v1
https://doi.org/10.1158/0008-5472.c.6510431.v1
Autor:
Ronnie Shapira-Frommer, Lindsey Rolfe, Jen Borrow, Jim Xiao, Jeff Isaacson, Sandra Goble, Lara Maloney, Heidi Giordano, Ana Montes, Tamar Safra, Lee-may Chen, Yvette Drew, Judith Balmaña, Susan M. Domchek, Manish R. Patel, Patricia LoRusso, Amit M. Oza, Howard A. Burris, Geoffrey I. Shapiro, Rebecca Kristeleit
Purpose: Rucaparib is a potent, oral, small-molecule PARP inhibitor. This phase I–II study was the first to evaluate single-agent oral rucaparib at multiple doses.Experimental Design: Part 1 (phase I) sought to determine the MTD, recommended phase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c8e514606746346332e3c5e0aa91d79
https://doi.org/10.1158/1078-0432.c.6526886.v1
https://doi.org/10.1158/1078-0432.c.6526886.v1
Autor:
Fergus J. Couch, Kathleen S. Hruska, Steven N. Hart, Eric C. Polley, Alvaro N.A. Monteiro, Siddhartha Yadav, Susan M. Domchek, Jie Na, Huaizhi Huang, Carolyn A. Dunn, Wei Shen, Sounak Gupta, Windy Berkofsky-Fessler, Susan Hiraki, Megan L. Marshall, Hana Yang, Maegan E. Roberts, Lisa R. Susswein, Chunling Hu
Supplementary Table from Classification of BRCA2 Variants of Uncertain Significance (VUS) Using an ACMG/AMP Model Incorporating a Homology-Directed Repair (HDR) Functional Assay
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0631fea32022e91b9bf2f3d3c59c8bfc
https://doi.org/10.1158/1078-0432.22487394.v1
https://doi.org/10.1158/1078-0432.22487394.v1
Autor:
Angela M. DeMichele, Peter J. O'Dwyer, Kevin R. Fox, Susan M. Domchek, Angela R. Bradbury, Maryann Gallagher, Colleen Redlinger, Jessica Burrell, Mark Rosen, Priti Lal, Michael Feldman, Andrea Troxel, Nicholas P. McAndrew, Amy S. Clark
Purpose:The CDK 4/6 inhibitor palbociclib rapidly and reversibly inhibits the cell cycle. The goal of this study was to exploit the cell cycle through intermittent, alternating dosing with palbociclib/paclitaxel to enhance efficacy. We determined the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97d5c8fe5b94ee5a0dd12850f50afa22
https://doi.org/10.1158/1078-0432.c.6527973.v1
https://doi.org/10.1158/1078-0432.c.6527973.v1
Autor:
Antonis C. Antoniou, Douglas F. Easton, Georgia Chenevix-Trench, Beth Karlan, Christine Walsh, Jenny Gross, Kate Nathanson, Simon A. Gayther, Lara Sucheston, Kunle Odunsi, Mary Beattie, Robert Nussbaum, Susan L. Neuhausen, Linda Steele, Karin Henriksson, Anna von Wachenfeld, Johanna Rantala, Paolo Aretini, Maria Caligo, Torben Kruse, Anne-Marie Gerdes, Mads Thomassen, Kevin Sweet, Leigha Senter, Amanda Ewart Toland, Evgeny Imyanitov, Anna Sokolenko, Mark H. Greene, Phuong L. Mai, Christine Rappaport, Muy-Kheng Tea, Christian F. Singer, Mia M. Gaudet, Rita Sakr, Kenneth Offit, Csilla Szabo, Noralane M. Lindor, Vernon S. Pankratz, Zachary Fredericksen, Xianshu Wang, Judy E. Garber, Nadine Tung, Wendy Rubinstein, Timothy R. Rebbeck, Stephen Fox, Max Yan, Emma D'Andrea, Simona Agata, Marco Montagna, Jacques Simard, Martine Dumont, Rosa B. Barkardottir, Adalgeir Arason, Bjarni A. Agnarsson, Joan Brunet, Conxi Lazaro, Ignacio Blanco, Kristiina Aittomäki, Päivi Heikkilä, Tuomas Heikkinen, Carmen Cañadas, Miguel de la Hoya, Trinidad Caldes, Beth N. Peshkin, Claudine Isaacs, Laure Barjhoux, Muriel Belotti, Dominique Stoppa-Lyonnet, Heidrun Gevensleben, Ines Schönbuchner, Raymonda Varon-Mateeva, Sabine Preisler-Adams, Doroteha Gadzicki, Helmut Deissler, Christian Sutter, Dieter Niederacher, Norbert Arnold, Karin Kast, Alfons Meindl, Barbara Wappenschmidt, Rita K. Schmutzler, Andrew K. Godwin, JoEllen Weaver, Catherine Houghton, Lucy E. Side, Mark T. Rogers, Lisa Walker, Carole Brewer, D. Gareth Evans, Debra Frost, Susan Peock, Rob B. van der Luijt, Mieke Kriege, Frans B. Hogervorst, Muhammad U. Rashid, Ute Hamann, Paolo Radice, Laura Ottini, Anna Laura Putignano, Riccardo Dolcetti, Barbara Pasini, Sara Volorio, Monica Barile, Bernard Peissel, Siranoush Manoukian, Javier Benítez, Alexandra Stavropoulou, Ana Osorio, Finn C. Nielsen, Thomas V. O. Hansen, Laima Tihomirova, Ramunas Janavicius, Esther M. John, Frances O'Malley, David Goldgar, Mary Beth Terry, Melissa C. Southey, Olga M. Sinilnikova, Sue Healey, Lesley McGuffog, Christoph Engel, Fergus J. Couch, Anna Marie Mulligan, Mark Sherman, Mark Robson, Amanda Spurdle, Susan J. Ramus, Heli Nevanlinna, Diana Eccles, Susan M. Domchek, Irene L. Andrulis, Daniel Barrowdale, Nasim Mavaddat
PDF file - 127K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4433dad8020516dbf09c92d1765c74ec
https://doi.org/10.1158/1055-9965.22438447.v1
https://doi.org/10.1158/1055-9965.22438447.v1
Autor:
Angela M. DeMichele, Peter J. O'Dwyer, Kevin R. Fox, Susan M. Domchek, Angela R. Bradbury, Maryann Gallagher, Colleen Redlinger, Jessica Burrell, Mark Rosen, Priti Lal, Michael Feldman, Andrea Troxel, Nicholas P. McAndrew, Amy S. Clark
Dose Cohort Scema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1073572a62e0113190fecd86383fd91e
https://doi.org/10.1158/1078-0432.22471713
https://doi.org/10.1158/1078-0432.22471713
Autor:
Eitan Friedman, Antonis C. Antoniou, Georgia Chenevix-Trench, Paul D.P. Pharoah, Andrew Lee, Sue Healey, Daniel Barrowdale, Lesley McGuffog, Karoline B. Kuchenbaecker, Åke Borg, Marie Stenmark Askmalm, Hans Ehrencrona, Anna von Wachenfeldt, Johanna Rantala, Yael Laitman, Uffe Birk Jensen, Mads Thomassen, Inge Sokilde Pedersen, Anders Bojesen, Amanda Ewart Toland, Irene L. Andrulis, Sandrine Tchatchou, Gord Glendon, Anna Marie Mulligan, Gad Rennert, Phuong L. Mai, Mark H. Greene, Catherine M. Phelan, Muy-Kheng M. Tea, Georg Pfeiler, Daphne Geschwantler Kaulich, Christine Rappaport, Christian F. Singer, Andreas Berger, Vijai Joseph, Liying Zhang, Mark E. Robson, Lauren Jacobs, Marina Corines, Kenneth Offit, Csilla I. Szabo, Xianshu Wang, Noralane M. Lindor, Fergus J. Couch, Curtis Olswold, Manuel R. Teixeira, Jocelyne Chiquette, Adalgeir Arason, Grzegorz Sukiennicki, Katarzyna Jaworska-Bieniek, Katarzyna Durda, Jacek Gronwald, Cezary Cybulski, Lidia Feliubadalo, Joan Brunet, Conxi Lazaro, Ignacio Blanco, Orland Diez, Edith Olah, J. Margriet Collée, Helena C. van Doorn, Margreet G.E.M. Ausems, Nicoline Hoogerbrugge, Maaike P.G. Vreeswijk, Annemarie H. van der Hout, Hanne E.J. Meijers-Heijboer, Theo A.M. van Os, Kristiina Aittomäki, Heli Nevanlinna, Pedro Perez Segura, Miguel de la Hoya, Larry J. Copeland, Gustavo C. Rodriguez, Michael L. Friedlander, Marion Piedmonte, Muriel Belotti, Sylvie Mazoyer, Pascal Pujol, Olivier Caron, Olga M. Sinilnikova, Nadia Boutry-Kryza, Lisa Golmard, Laurence Venat-Bouvet, Laure Barjhoux, Isabelle Coupier, Francesca Damiola, Dominique Stoppa-Lyonnet, Claude Houdayer, Capucine Delnatte, Bruno Buecher, Brigitte Bressac-de Paillerets, Shan Wang-Gohrke, Barbara Wappenschmidt, Raymonda Varon-Mateeva, Norbert Arnold, Nina Ditsch, Kerstin Rhiem, Karin Kast, Hansjoerg Plendl, Doris Steinemann, Dieter Niederacher, Christoph Engel, Christian Sutter, Andrea Gehrig, Alfons Meindl, Tom Van Maerken, Kathleen Claes, Andrew K. Godwin, Trevor Cole, Steve Ellis, Shirley V. Hodgson, Rosemarie Davidson, Radka Platte, Patrick J. Morrison, Mary E. Porteous, Mark T. Rogers, M. John Kennedy, Lucy E. Side, Louise Izatt, Lisa Walker, Julian Barwell, Julian Adlard, Marc Tischkowitz, Jackie Cook, Angela Brady, Diana Eccles, Debra Frost, D. Gareth R. Evans, Claire Foo, Carole Brewer, Alan Donaldson, Judy E. Garber, Florentia Fostira, Athanassios Vratimos, Paolo Radice, Maria Grazia Tibiletti, Aline Martayan, Laura Papi, Giuseppe Giannini, Alessandra Viel, Stefano Fortuzzi, Frederique Mariette, Filomena Ficarazzi, Monica Barile, Giulietta Scuvera, Daniela Zaffaroni, Bernard Peissel, Siranoush Manoukian, Jeffrey N. Weitzel, Kathleen R. Blazer, Edye E. Conway, Javier Benitez, Cristina Martínez-Bouzas, Ana Osorio, Lars Jønson, Bent Ejlertsen, Anne-Marie Gerdes, Thomas V.O. Hansen, Susan L. Neuhausen, Yuan Chun Ding, Elizabeth J. van Rensburg, Cecilia M. Dorfling, Ramunas Janavicius, Saundra S. Buys, David E. Goldgar, Melissa C. Southey, Alex Miron, Wendy K. Chung, Jenny Lester, Sandra Orsulic, Beth Y. Karlan, Banu K. Arun, Timothy R. Rebbeck, Susan M. Domchek, Katherine L. Nathanson, Robert L. Nussbaum, Olufunmilayo I. Olopade, Encarna B. Gómez Garcia, Anna Jakubowska, Jan Lubinski, Laura Matricardi, Marco Montagna, Ana-Teresa Maia, Felicity Lose, Logan C. Walker, Amanda B. Spurdle, Frederieke H. van der Baan, Marjanka K. Schmidt, Matti A. Rookus, Bowang Chen, Stefan Wilkening, Ute Hamann, Douglas F. Easton, Rosalind A. Eeles, Penny Soucy, Jacques Simard, Rita K. Schmutzler, Anja Rudolph, Kirsten B. Moysich, Jenny Chang-Claude, Paolo Peterlongo
Background:BRCA1 and BRCA2 mutation carriers are at substantially increased risk for developing breast and ovarian cancer. The incomplete penetrance coupled with the variable age at diagnosis in carriers of the same mutation suggests the existence of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b50629d680afbc648da1757bc0ba5038
https://doi.org/10.1158/1055-9965.c.6516276
https://doi.org/10.1158/1055-9965.c.6516276
Autor:
Ronnie Shapira-Frommer, Lindsey Rolfe, Jen Borrow, Jim Xiao, Jeff Isaacson, Sandra Goble, Lara Maloney, Heidi Giordano, Ana Montes, Tamar Safra, Lee-may Chen, Yvette Drew, Judith Balmaña, Susan M. Domchek, Manish R. Patel, Patricia LoRusso, Amit M. Oza, Howard A. Burris, Geoffrey I. Shapiro, Rebecca Kristeleit
Supplementary data include the following: Figure S1. Rucaparib plasma concentration-time profiles following once daily oral administration Figure S2. Rucaparib plasma concentration-time profiles following twice daily oral administration Figure S3. Ob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5956bf8ec49e11a05528435711dac1d4
https://doi.org/10.1158/1078-0432.22468277.v1
https://doi.org/10.1158/1078-0432.22468277.v1
Autor:
Katrina Armstrong, Susan M. Domchek, Christopher Jepson, Lynn M. Schuchter, Michael E. Ming, Peter A. Kanetsky, Kathryn Volpicelli, Karen Glanz
Background: Little is known about the impact of knowledge of CDKN2A and MC1R genotype on melanoma prevention behaviors like sun avoidance and skin examination in the context of familial melanoma.Methods: Seventy-three adults with a family history of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ee989a0a83679affb20d926cebb89d1
https://doi.org/10.1158/1055-9965.c.6515419.v1
https://doi.org/10.1158/1055-9965.c.6515419.v1