Zobrazeno 61 - 70
of 159
pro vyhledávání: '"Shingo Kajimura"'
Autor:
Shingo Kajimura, Carlos H.G. Sponton
Publikováno v:
Cell Metabolism. 26:285-287
The rise of follicle-stimulating hormone (FSH) is a hallmark of menopause associated with osteoporosis and visceral adiposity. In Nature, Zaidi and colleagues (Liu et al., 2017) report that blocking FSH action reduces body fat by promoting brown/beig
Autor:
Alexander J. Knights, Yingxu Ma, Margo P. Emont, Jianke Gong, X.Z. Shawn Xu, Xiaona Qiao, Shingo Kajimura, Shanshan Liu, Jun Wu, Yong Chen, Jine Wang, Heejin Jun
Publikováno v:
Dev Cell
Summary Maintaining energy homeostasis upon environmental challenges, such as cold or excess calorie intake, is essential to the fitness and survival of mammals. Drug discovery efforts targeting β-adrenergic signaling have not been fruitful after de
Autor:
Shingo Kajimura, Carlos H.G. Sponton
Publikováno v:
EMBO Molecular Medicine
EMBO Molecular Medicine, Vol 10, Iss 8, Pp n/a-n/a (2018)
EMBO Molecular Medicine, Vol 10, Iss 8, Pp n/a-n/a (2018)
Prevalence of type 2 diabetes (T2D) and obesity is increasing worldwide. Currently available therapies are not suited for all patients in the heterogeneous obese/T2D population, hence the need for novel treatments. Fibroblast growth factor 21 (FGF21)
Autor:
Evanna L. Mills, Lawrence Kazak, Jessica B. Spinelli, Ryan Garrity, Steven P. Gygi, Takeshi Yoneshiro, Edward T. Chouchani, Marcia C. Haigis, Michael P. Murphy, Shingo Kajimura, Gina Z. Lu, Kerry A. Pierce, Mark P. Jedrychowski, Sara Vidoni, Sally Winther, Clary B. Clish, Alexander S. Banks
Brown and beige adipose tissue thermogenesis can combat metabolic disease, which requires activation by extrinsic stimuli(1). Adipocyte lipolysis through cAMP/PKA signaling initiates thermogenic respiration, and this pathway has been subject to longs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77b187742acd648ac777c4242a0440d3
https://europepmc.org/articles/PMC7045287/
https://europepmc.org/articles/PMC7045287/
Autor:
Carlos H.G. Sponton, Shingo Kajimura
Beige adipocytes are an inducible form of thermogenic adipose cells that emerge within the white adipose tissue in response to a variety of environmental stimuli, such as chronic cold acclimation. Similar to brown adipocytes that reside in brown adip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e4d6c9a45155a64ef580339d15db9e9
https://europepmc.org/articles/PMC6692864/
https://europepmc.org/articles/PMC6692864/
Autor:
Xiaodan Lu, Kenji Ikeda, Pema Maretich, Shingo Kajimura, Yong Chen, Svetlana Altshuler-Keylin, Takeshi Yoneshiro, Carlos H.G. Sponton, Qiang Wang
Publikováno v:
Science signaling. 11(527)
Beige adipocytes are an inducible form of mitochondria-enriched thermogenic adipocytes that emerge in response to external stimuli, such as chronic cold exposure. We have previously shown that after the withdrawal of external stimuli, beige adipocyte
Autor:
Roman Camarda, Jeremy Williams, Serghei Malkov, Lisa J. Zimmerman, Suzanne Manning, Dvir Aran, Andrew Beardsley, Daniel Van de Mark, Yong Chen, Charles Berdan, Sharon M. Louie, Celine Mahieu, Daphne Superville, Matthew Gruner, Juliane Winkler, Elizabeth Willey, John D. Gagnon, Kosaku Shinoda, K. Mark Ansel, Zena Werb, Daniel K. Nomura, Shingo Kajimura, Atul J. Butte, Melinda E. Sanders, Daniel C. Liebler, Hope Rugo, Gregor Krings, John A. Shepherd, Andrei Goga
During tumorigenesis, a heterotypic interface exists between cancer and stromal cells that can both support and repress tumor growth. In the breast, studies have demonstrated a pro-tumorigenic role for adipocytes. However, the molecular mechanisms by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62d842c98279efc9d30a95ceb92bbc63
https://doi.org/10.1101/277939
https://doi.org/10.1101/277939
Autor:
Kenji Ikeda, Carlos H.G. Sponton, Kazuki Tajima, Qiang Wang, Yong Chen, Kyeongkyu Kim, Zachary Brown, Takeshi Yoneshiro, Kosaku Shinoda, Annarita Scaramozza, Shingo Kajimura, Andrew S. Brack
Publikováno v:
Nature, vol 565, iss 7738
Nature
Nature
Environmental cues profoundly affect cellular plasticity in multicellular organisms. For instance, exercise promotes a glycolytic-to-oxidative fiber-type switch in skeletal muscle, and cold acclimation induces beige adipocyte biogenesis in adipose ti
Autor:
Diana L. Alba, Jingyi Chi, Shingo Kajimura, Kosaku Shinoda, Kenji Ikeda, Pema Maretich, Yangyu Yang, Yutaka Hasegawa, Daniel Stifler, Suneil K. Koliwad, Paul Cohen, Yasushi Ishigaki, Takashi Hosono, Yong Chen
Publikováno v:
Cell metabolism, vol 27, iss 1
Summary Adipose tissue fibrosis is a hallmark of malfunction that is linked to insulin resistance and type 2 diabetes; however, what regulates this process remains unclear. Here we show that the PRDM16 transcriptional complex, a dominant activator of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f631fabf50efb970fd99a3574704fc68
https://europepmc.org/articles/PMC5765755/
https://europepmc.org/articles/PMC5765755/
Publikováno v:
Trends in endocrinology and metabolism: TEM. 29(3)
Two types of thermogenic fat cells, brown adipocytes and beige adipocytes, play a key role in the regulation of systemic energy homeostasis in mammals. Both brown fat and beige fat possess thermogenic properties in addition to common morphological an