Zobrazeno 51 - 60
of 227
pro vyhledávání: '"Shigeki Ohtake"'
Autor:
Masahiro Mihara, Kazuma Ohyashiki, Moritaka Gotoh, Kazunori Ohnishi, Shigeki Ohtake, Shuichi Miyawaki, Atsushi Wakita, Yoshikazu Ito, Tomoki Naoe, Satoru Takada
Publikováno v:
International Journal of Hematology. 96:485-491
We conducted a phase 1 study of a combination of gemtuzumab ozogamicin (GO) plus conventional chemotherapy in elderly patients (≥65 years old) with relapsed or refractory CD33-positive acute myeloid leukemia (AML). Patients received a standard dose
Autor:
Hidesaku Asakura, Akihiro Yachie, Akiko Sekiya, Keiko Maruyama, Eriko Morishita, Shigeki Ohtake, Takeo Yuno
Publikováno v:
Thrombosis Research. 130(3):e188-e193
Introduction: Heme oxygenase-1 (HO-1) is the rate limiting enzyme that catalyzes the conversion of heme into biliverdin, free iron, and carbon monoxide (CO). The first human case of HO-1 deficiency showed abnormalities in blood coagulation and the fi
Autor:
Shigeki Ohtake, Tomohide Tsuda, Hidesaku Asakura, Xiuri Jin, Eriko Morishita, Tomoe Hayashi, Yasuko Kadohira, Takashi Wada, Masami Shibayama, Akiko Sekiya, Haruka Nomoto
Publikováno v:
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis. 23(7)
Introduction: Careful monitoring of the hypercoagulable state is required during pregnancy. However, coagulation and fibrinolysis markers are not fully utilized because there are no reference values reflective of coagulation and fibrinolysis dynamics
Autor:
Hiroyuki Mano, Toshihide Ueno, Shigeki Ohtake, Toru Sakura, Tomoki Naoe, Mineo Kurokawa, Shinji Kohsaka, Junko Takita, Eisei Kondo, Toshiaki Yujiri, Fumihiko Hayakawa, Akiko Kunita, Koichiro Doi, Takahiko Yasuda, Eirin Sai, Katsumichi Fujimaki, Yasushi Miyazaki, Yasunori Ueda, Masahito Kawazu, Shinobu Tsuzuki, Naoto Imoto, Shinya Kojima, Yasutaka Aoyama, Shinichi Morishita, Masafumi Taniwaki, Masashi Fukayama, Hitoshi Kiyoi
Publikováno v:
Nature genetics. 48(5)
The oncogenic mechanisms underlying acute lymphoblastic leukemia (ALL) in adolescents and young adults (AYA; 15-39 years old) remain largely elusive. Here we have searched for new oncogenes in AYA-ALL by performing RNA-seq analysis of Philadelphia ch
Autor:
Yusuke Sato, Seishi Ogawa, Shigeki Ohtake, Yumi Sasaki, Motohiro Kato, Satoko Morishima, Masashi Sanada, Kohei Hosokawa, Takamasa Katagiri, Yuka Mori, Shinji Nakao, Aiko Sato-Otsubo, Yasuo Morishima, Koichi Kashiwase
Publikováno v:
Blood. 118:6601-6609
Idiopathic aplastic anemia (AA) is a common cause of acquired BM failure. Although autoimmunity to hematopoietic progenitors is thought to be responsible for its pathogenesis, little is known about the molecular basis of this autoimmunity. Here we sh
Autor:
Shuichi Miyawaki, Kensuke Usuki, Fumihiko Kimura, Shigehisa Tamaki, Hiroyuki Fujita, Toshikazu Yamaguchi, Isamu Sugiura, Takaaki Ono, Kunio Kitamura, Kenichi Tadokoro, Yasutaka Aoyama, Nobuhiko Emi, Hiroyasu Kaya, Ryuzo Ohno, Shigeki Ohtake, Heiwa Kanamori, Tomoki Naoe, Kazunori Ohnishi
Publikováno v:
Leukemia Research. 35:598-603
BCR-ABL1 kinase domain mutations were evaluated in 60 imatinib-resistant patients with Philadelphia-positive (Ph + ) leukemia using PCR-Invader assay and direct sequencing. In chronic myelogenous leukemia (CML) – chronic phase (CP), 5 had P-loop mu
Autor:
Shin Fujisawa, Norio Asou, Kazunori Ohnishi, Hitoshi Kiyoi, Atsushi Fujieda, Hisashi Sakamaki, Sumihisa Honda, Shigeki Ohtake, Noriko Usui, Yasushi Miyazaki, Yukihiko Kimura, Shuichi Miyawaki, Takahisa Yamane, Ryuzo Ohno, Tadashi Nagai, Toru Sakura, Chiaki Nakaseko, Masatomo Takahashi, Katsuji Shinagawa, Koichi Miyamura, Hiroshi Handa, Masafumi Taniwaki, Fumiharu Yagasaki, Tomoki Naoe
Publikováno v:
Blood. 117:2366-2372
We conducted a prospective randomized study to assess the optimal postremission therapy for adult acute myeloid leukemia in patients younger than 65 years in the first complete remission. A total of 781 patients in complete remission were randomly as
Publikováno v:
European Journal of Haematology. 86:226-236
Glycosylphosphatidylinositol-anchored protein-deficient (GPI-AP−) T cells can be detected in some patients with bone marrow failure (BMF), but the link between these cells and BMF pathophysiology remains to be elucidated. To clarify the significanc
Autor:
Mika Omote, Akiko Sekiya, Yoshiyuki Wakugawa, Keiko Maruyama, Yasuko Kadohira, Tomoe Hayashi, Moeko Shinohara, Eriko Morishita, Shigeki Ohtake, Shinji Nakao, Itsumi Shimogawara, Megumi Karato, Hidesaku Asakura
Publikováno v:
International Journal of Hematology. 93:216-219
An inherited antithrombin deficiency is an autosomal dominant thrombotic disorder. We identified two pedigrees of inherited type I antithrombin deficiency and two responsible mutations in each. A novel 21-22delAA appeared to have caused a frameshift
Autor:
K Miyamura, Masami Inoue, Takakazu Kawase, M Onizuka, Nakao S, Hiroshi Sao, Tetsuya Fukuda, Yasuo Morishima, J. L. Espinoza, Akiyoshi Takami, Shigeki Ohtake, Yoshihisa Kodera, H Akiyama, Shinichiro Okamoto
Publikováno v:
Bone Marrow Transplantation. 46:1455-1463
IL-17 has an important role in the host defense against extracellular pathogens and the pathophysiology of autoimmune diseases. This study retrospectively examined the impact of a single-nucleotide polymorphism (rs2275913, G197A) in the IL-17 gene of