Zobrazeno 11 - 19
of 19
pro vyhledávání: '"Shaima'a Hamarsheh"'
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Oncogenic KRAS mutations are the most frequent mutations in human cancer, but most difficult to target. While sustained proliferation caused by oncogenic KRAS-downstream signalling is a main driver of carcinogenesis, there is increasing evidence that
Autor:
Franziska M. Uhl, Dietmar Pfeifer, Melanie Boerries, Donatella De Feo, Shaima’a Hamarsheh, Heiko Becker, Benedikt S. Saller, Lena Osswald, Claudia Lengerke, Janaki Manoja Vinnakota, Miriam Erlacher, Geoffroy Andrieux, Justus Duyster, Sandra Duquesne, Robert Zeiser, Martina Konantz, Mark E. Cooper, Annette Schmitt-Graeff, Tilman Brummer, Christoph Schürch, Charlotte M. Niemeyer, Nils Venhoff, Olaf Groß, Michael Lübbert, Khalid Shoumariyeh, Burkhard Becher, Susanne Unger, Bruce R. Blazar
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature Communications
Oncogenic Ras mutations occur in various leukemias. It was unclear if, besides the direct transforming effect via constant RAS/MEK/ERK signaling, an inflammation-related effect of KRAS contributes to the disease. Here, we identify a functional link b
Autor:
Lena, Osswald, Shaima'a, Hamarsheh, Franziska Maria, Uhl, Geoffroy, Andrieux, Claudius, Klein, Christine, Dierks, Sandra, Duquesne, Lukas M, Braun, Annette, Schmitt-Graeff, Justus, Duyster, Melanie, Boerries, Tilman, Brummer, Robert, Zeiser
Publikováno v:
Molecular cancer research : MCR. 19(9)
The bone marrow microenvironment (BMME) is key player in regulation and maintenance of hematopoiesis. Oncogenic
Autor:
Shaima'a, Hamarsheh, Lena, Osswald, Benedikt S, Saller, Susanne, Unger, Donatella, De Feo, Janaki Manoja, Vinnakota, Martina, Konantz, Franziska M, Uhl, Heiko, Becker, Michael, Lübbert, Khalid, Shoumariyeh, Christoph, Schürch, Geoffroy, Andrieux, Nils, Venhoff, Annette, Schmitt-Graeff, Sandra, Duquesne, Dietmar, Pfeifer, Matthew A, Cooper, Claudia, Lengerke, Melanie, Boerries, Justus, Duyster, Charlotte M, Niemeyer, Miriam, Erlacher, Bruce R, Blazar, Burkard, Becher, Olaf, Groß, Tilman, Brummer, Robert, Zeiser
Publikováno v:
Nature Communications
Oncogenic Ras mutations occur in various leukemias. It was unclear if, besides the direct transforming effect via constant RAS/MEK/ERK signaling, an inflammation-related effect of KRAS contributes to the disease. Here, we identify a functional link b
Autor:
Heiko Bruns, Stefano Ricagno, Cindy Flamann, Shaima’a Hamarsheh, Frank Neumann, Andreas Mackensen, Katrin Bitterer, Maike Büttner-Herold, Cristina Visentin, Robert Zeiser, Christian Bach, Dimitrios Mougiakakos, Stefan Haskamp, Daniel Hofbauer, Martin Böttcher, Savita Bisht, Chiara De Luca, Fabio Moda, Martin Eberhardt, Luca Broggini, Bernd M. Spriewald, Julio Vera, Mario M. Zaiss, Jens Nolting, Simon Völkl
Publikováno v:
Immunity. 54:1772-1787.e9
As substantial constituents of the multiple myeloma (MM) microenvironment, pro-inflammatory macrophages have emerged as key promoters of disease progression, bone destruction, and immune impairment. We identify beta-2-microglobulin (β2m) as a driver
Autor:
Shaima’a Hamarsheh, Kathrin Hanke, Melanie Boerries, Jung-Seok Kim, Justus Duyster, Nimitha R. Mathew, Steffen Jung, Nadia El-Khawanky, Dominik Schmidt, Thomas Blank, Louise Chappell-Maor, Tobias Goldmann, Jürgen Finke, Daniel Erny, Gabriele Ihorst, Marco Prinz, Petya Apostolova, Janaki Manoja Vinnakota, Bruce R. Blazar, Geoffroy Andrieux, Robert Zeiser
Publikováno v:
J Clin Invest
Journal of Clinical Investigation
Journal of Clinical Investigation
Acute graft-versus-host disease (GVHD) can affect the central nervous system (CNS). The role of microglia in CNS-GVHD remains undefined. In agreement with microglia activation, we found that profound morphological changes and MHC-II and CD80 upregula
Autor:
Daniel Hofbauer, Savita Bisht, Robert Zeiser, Jens Nolting, Heiko Bruns, Shaima’a Hamarsheh, Dimitrios Mougiakakos, Andreas Mackensen, Frank Neumann, Stefano Ricagno, Maike Büttner-Herold, Katrin Bitterer, Martin Boettcher, Martin Eberhardt, Mario M. Zaiss
Publikováno v:
Blood. 134:2314-2314
Multiple myeloma (MM) is closely dependent on cross-talk between malignant plasma cells and cellular components of the inflammatory bone marrow milieu, which promotes disease progression, bone destruction and immune-impairment. However, the molecular
Autor:
Tilman Brummer, Shaima’a Hamarsheh, Olaf Groß, Claudia Lengerke, Oliver Gorka, Lena Osswald, Justus Duyster, Melanie Börries, Miriam Erlacher, Robert Zeiser
Publikováno v:
Blood. 132:2618-2618
Oncogenic Ras mutations occur frequently in myelodysplastic (MDS) and myeloproliferative syndromes (MPN). It was unclear if besides the direct transforming effect via constant RAS/MEK/ERK signaling, an inflammation related effect of KRAS contributes
Autor:
Carlos Caldas, Chitra Joseph, Christopher C. Nolan, Emad A. Rakha, Elena Provenzano, Ian O. Ellis, Andrew R. Green, Shaima’a Hamarsheh, Abhik Mukherjee, Madeleine L. Craze
Publikováno v:
European Journal of Surgical Oncology (EJSO). 42:S251
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