Zobrazeno 61 - 70
of 189
pro vyhledávání: '"Serge Y. Fuchs"'
Autor:
Nathan Shores, Partha K. Chandra, Lili Bao, Tong Wu, Kyoung-Sub Song, Darren P. Baker, Curt H. Hagedorn, Srikanta Dash, Fatma M. Aboulnasr, William C. Wimley, Shuanghu Liu, Luis A. Balart, Serge Y. Fuchs
Publikováno v:
The American Journal of Pathology. 184(1):214-229
A stable and persistent Hepatitis C virus (HCV) replication cell culture model was developed to examine clearance of viral replication during long-term treatment using interferon-α (IFN-α), IFN-λ, and ribavirin (RBV). Persistently HCV-infected cel
Autor:
Rong-Bing Guo, Serge Y. Fuchs, Yuliya V. Katlinskaya, Haineng Xu, Kanstantsin V. Katlinski, Xinyuan Liu, Shuai Wu, Lieyang Chen, Fang Xianlong, Kangjian Zhang, Jing Xiao, Xiao-Fei Yin, Xi Jun Liu, Da-Cheng Wang, Hui-Ling Li, Liang Chu, Yuan-Qin Yang, Guang-Wen Wei, Yan-Ni Xu, Sujing Yuan
Purpose: Antiproliferative, antiviral, and immunomodulatory activities of endogenous type I IFNs (IFN1) prompt the design of recombinant IFN1 for therapeutic purposes. However, most of the designed IFNs exhibited suboptimal therapeutic efficacies aga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd92768b7d1f5508d47610f6222e352a
https://europepmc.org/articles/PMC5373932/
https://europepmc.org/articles/PMC5373932/
Autor:
Nektaria Maria Leli, Frank Chinga, Christine Polte, Paul P. Wang, Davide Ruggero, Feven Tameire, Ioannis I. Verginadis, Alexandra M Monroy, Constantinos Koumenis, Crystal S. Conn, Weixuan Fu, Rani Ojha, J. Alan Diehl, Zoya Ignatova, Andrew V. Kossenkov, Serge Y. Fuchs, Jiangbin Ye, Ravi K. Amaravadi, Carlo Salas Salinas
Publikováno v:
Nature Cell Biology. 21:1052-1052
Autor:
Nicholas J Matheson, Susan W. Volk, Ahmad A. Tarhini, J. Alan Diehl, Jun Gui, Paul J. Lehner, Yuliya V. Katlinskaya, Angelica Ortiz, Constantinos Koumenis, Angela K Brice, John M. Kirkwood, Wei Guo, Hallgeir Rui, Christina Cho, Simran Handa, Sabyasachi Bhattacharya, Christopher J. Carbone, Pengfei Yu, Sonja Ludwig, Cindy Sander, Serge Y. Fuchs, Andy J. Minn, Robin Antrobus, Farima Zahedi, Qiujing Yu, Kim Wals, Theresa L. Whiteside, Victor Haas, Kanstantsin V. Katlinski
Publikováno v:
Cancer Cell. 35:33-45.e6
Tumor-derived extracellular vesicles (TEV) "educate" healthy cells to promote metastases. We found that melanoma TEV downregulated type I interferon (IFN) receptor and expression of IFN-inducible cholesterol 25-hydroxylase (CH25H). CH25H produces 25-
Autor:
Christopher J. Carbone, Serge Y. Fuchs
Publikováno v:
Journal of Cellular Biochemistry. 115:8-16
Activation of cytokine receptor-associated Janus kinases (JAKs) mediates most, if not all, of the cellular responses to peptide hormones and cytokines. Consequently, JAKs play a paramount role in homeostasis and immunity. Members of this family of ty
Autor:
Jeffrey A. Hooke, Lynn M. Neilson, Thai H. Tran, Inna Chervoneva, Albert J. Kovatich, Hallgeir Rui, Craig D. Shriver, Chengbao Liu, Boris Freydin, Serge Y. Fuchs, Amy R. Peck, Melanie A. Girondo, Takahiro Sato, Terry Hyslop, Chelain R. Goodman
Publikováno v:
Oncogene
Prolactin controls the development and function of milk-producing breast epithelia but also supports growth and differentiation of breast cancer, especially luminal subtypes. A principal signaling mediator of prolactin, Stat5, promotes cellular diffe
Autor:
Jing Jiang, Jie Xu, Dongmei Sun, Stuart J. Frank, Wen Y. Chen, Yue Zhang, Serge Y. Fuchs, John F. Langenheim, Hao Yu, Deepti Bahl, Luqin Deng
Publikováno v:
Molecular Endocrinology. 27:266-279
GH and prolactin (PRL) are structurally related hormones that exert important effects in disparate target tissues. Their receptors (GHR and PRLR) reside in the cytokine receptor superfamily and share signaling pathways. In humans, GH binds both GHR a
Autor:
Yan Li, Albert C. Koong, Constantinos Koumenis, Haiyan Zhang, George J. Cerniglia, John T. Cunningham, Lori S. Hart, Alexander E. Perl, Davide Ruggero, Andrei Thomas-Tikhonenko, Bo Qiu, Amit Maity, J. Alan Diehl, Serge Y. Fuchs, Ian G. Mills, Yan Gao, Changhong Li, Souvik Dey, Feven Tameire, Stacey L. Lehman, Meixia Bi, Huayi Liu, Tatini Datta
Publikováno v:
The Journal of clinical investigation, vol 122, iss 12
The proto-oncogene c-Myc paradoxically activates both proliferation and apoptosis. In the pathogenic state, c-Myc–induced apoptosis is bypassed via a critical, yet poorly understood escape mechanism that promotes cellular transformation and tumorig
Autor:
Ekaterina Bobrovnikova-Marjon, Dariusz Pytel, Jake A. Kushner, Brian Frederick, Hui Zheng, Constantinos Koumenis, J. Alan Diehl, Nancy L. Maas, Nilesh Chitnis, Lewis A. Chodosh, Dhruv K. Pant, Serge Y. Fuchs
Publikováno v:
Molecular Cell. 48:353-364
MicroRNAs typically function at the level of posttranscriptional gene silencing within the cytoplasm; however, increasing evidence suggests that they may also function in nuclear, Argonaut-containing complexes, to directly repress target gene transcr
Autor:
Victoria P. Werth, Darren P. Baker, Hallgeir Rui, Serge Y. Fuchs, Christine Marshall, Michael D. Gober, Kanstantsin V. Katlinski, John T. Seykora, Meena R. Sharma, Xiaoping Yang, Jun Gui
Phototherapy with ultraviolet (UV) light is a standard treatment for psoriasis, yet the mechanisms underlying the therapeutic effects are not well understood. Studies in human and mouse keratinocytes and in the skin tissues from human patients and mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb19fab45bd84fbcf46b299c96b0bf5a
https://europepmc.org/articles/PMC5035634/
https://europepmc.org/articles/PMC5035634/