Zobrazeno 41 - 50
of 85
pro vyhledávání: '"Samuel K. Handelman"'
Autor:
Sangmin Lee, Michael S. Simon, Ellen K. Ritchie, Monica L. Guzman, Pinkal Desai, Michael B. Samuel, Rebecca D. Jackson, Gail J. Roboz, Alexander P. Reiner, Alan Wu, Duane C. Hassane, Samuel K. Handelman, Paul J. Christos, JoAnn E. Manson
Publikováno v:
Blood. 134:1199-1199
Background: Whole genome analyses of peripheral blood has demonstrated that acquired somatic mutations in peripheral blood also known as clonal hematopoiesis of indeterminate potential (CHIP) is present in up to 10% of individuals older than 60 years
Autor:
Philip M. Brown, Olga V. Belyaeva, Cara Nestlerode, Natalia Y. Kedishvili, Katherine Valles, Yaron Rotman, Arun J. Sanyal, Yanhua Chen, Emmanuel Thomas, Yanling Ma, Vincent L. Chen, Ynto S. de Boer, Elizabeth K. Speliotes, Suman Karki, Joseph M. Zmuda, Christopher Koh, Xiaomeng Du, Koji Fujita, Samuel K. Handelman, David E. Kleiner, T. Jake Liang
Publikováno v:
Hepatology (Baltimore, Md.). 69(4)
Non-alcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disease. A single nucleotide polymorphism (SNPs), rs6834314, was associated with serum liver enzymes in the general population, presumably reflecting liver fat or injury. We
Autor:
Hans Bisgaard, Leon Eyrich Jessen, John G. Logan, Gudmar Porleifsson, Hou-Feng Zheng, Annelies C. Ham, Tarunveer S. Ahluwalia, Struan F.A. Grant, Yongmei Liu, M. Carola Zillikens, Ivana Nedeljkovic, Mattias Lorentzon, Daniel S. Evans, Kari Stefansson, Jing Hua Zhao, Gunnar Sigurdsson, Fiona E. McGuigan, Rebecca D. Jackson, Douglas P. Kiel, M. Arfan Ikram, David Karasik, J. Brent Richards, Scott Wilson, Tamara B. Harris, Najaf Amin, James F. Wilson, Peter I. Croucher, John A Robbins, Carolina Medina-Gomez, Raimo Joro, Frances M K Williams, Stuart H. Ralston, Unnur Styrkarsdottir, Timo A. Lakka, Jian'an Luan, Cheryl L. Ackert-Bicknell, John P. Walsh, Benjamin H. Mullin, Fernando Pires Hartwig, Bruce M. Psaty, Robert A. Scott, Claes Ohlsson, Janine F. Felix, Bram C. J. van der Eerden, Jonathan H Tobias, Mike A. Nalls, Christian J. Carlsson, Cindy G. Boer, Kun Zhu, Tim D. Spector, Linda Broer, Babette S. Zemel, Martin den Heijer, Mustafa Atalay, Eric S. Orwoll, David M. Evans, Ruifang Li-Gao, John P. Kemp, Katharina E. Schraut, Dennis O. Mook-Kanamori, Kristina Åkesson, Katerina Trajanoska, Maria Nethander, Evangelia E. Ntzani, Cornelia M. van Duijn, Craig E. Pennell, Yanhua Zhou, Ching-Ti Liu, Vincenzo Forgetta, Claudia Langenberg, Fernando Rivadeneira, Vincent W. V. Jaddoe, Nathalie van der Velde, J. H. Duncan Bassett, Bernardo L. Horta, Jeroen van de Peppel, Samuel K. Handelman, Evangelos Evangelou, Klaus Bønnelykke, Renée de Mutsert, Denise H. M. Heppe, Nicholas J. Wareham, Graham R. Williams, Bo L. Chawes, Andre J. van Wijnen, Carol A. Wang, Mohsen Ghanbari, Alessandra Chesi, André G. Uitterlinden
Publikováno v:
Medina-Gomez, C, Kemp, J P, Trajanoska, K, Luan, J, Chesi, A, Ahluwalia, T S, Mook-Kanamori, D O, Ham, A, Hartwig, F P, Evans, D S, Joro, R, Nedeljkovic, I, Zheng, H-F, Zhu, K, Atalay, M, Liu, C-T, Nethander, M, Broer, L, Porleifsson, G, Mullin, B H, Handelman, S K, Nalls, M A, Jessen, L E, Heppe, D H M, Richards, J B, Wang, C, Chawes, B, Schraut, K E, Amin, N, Wareham, N, Karasik, D, Van der Velde, N, Ikram, M A, Zemel, B S, Zhou, Y, Carlsson, C J, Liu, Y, McGuigan, F E, Boer, C G, Bonnelykke, K, Ralston, S H, Robbins, J A, Walsh, J P, Zillikens, M C, Langenberg, C, Li-Gao, R, Williams, F M K, Harris, T B, Akesson, K, Jackson, R D, Sigurdsson, G, den Heijer, M, van der Eerden, B C J, van de Peppel, J, Spector, T D, Pennell, C, Horta, B L, Felix, J F, Zhao, J H, Wilson, S G, de Mutsert, R, Bisgaard, H, Styrkarsdottir, U, Jaddoe, V W, Orwoll, E, Lakka, T A, Scott, R, Grant, S F A, Lorentzon, M, van Duijn, C M, Wilson, J F, Stefansson, K, Psaty, B M, Kiel, D P, Ohlsson, C, Ntzani, E, van Wijnen, A J, Forgetta, V, Ghanbari, M, Logan, J G, Williams, G R, Bassett, J H D, Croucher, P I, Evangelou, E, Uitterlinden, A G, Ackert-Bicknell, C L, Tobias, J H, Evans, D M & Rivadeneira, F 2018, ' Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects ', American journal of human genetics, vol. 102, no. 1, pp. 88-102 . https://doi.org/10.1016/j.ajhg.2017.12.005
American Journal of Human Genetics, 102(1), 88-102. Cell Press
Medina-Gomez, C, Kemp, J P, Trajanoska, K, Luan, J, Chesi, A, Ahluwalia, T S, Mook-Kanamori, D O, Ham, A, Hartwig, F P, Evans, D S, Joro, R, Nedeljkovic, I, Zheng, H-F, Zhu, K, Atalay, M, Liu, C-T, Nethander, M, Broer, L, Porleifsson, G, Mullin, B H, Handelman, S K, Nalls, M A, Jessen, L E, Heppe, D H M, Richards, J B, Wang, C, Chawes, B, Schraut, K E, Amin, N, Wareham, N, Karasik, D, Van der Velde, N, Ikram, M A, Zemel, B S, Zhou, Y, Carlsson, C J, Liu, Y, McGuigan, F E, Boer, C G, Bønnelykke, K, Ralston, S H, Robbins, J A, Walsh, J P, Zillikens, M C, Langenberg, C, Li-Gao, R, Williams, F M K, Harris, T B, Akesson, K, Jackson, R D, Sigurdsson, G, den Heijer, M, van der Eerden, B C J, van de Peppel, J, Spector, T D, Pennell, C, Horta, B L, Felix, J F, Zhao, J H, Wilson, S G, de Mutsert, R, Bisgaard, H, Styrkársdóttir, U, Jaddoe, V W, Orwoll, E, Lakka, T A, Scott, R, Grant, S F A, Lorentzon, M, van Duijn, C M, Wilson, J F, Stefansson, K, Psaty, B M, Kiel, D P, Ohlsson, C, Ntzani, E, van Wijnen, A J, Forgetta, V, Ghanbari, M, Logan, J G, Williams, G R, Bassett, J H D, Croucher, P I, Evangelou, E, Uitterlinden, A G, Ackert-Bicknell, C L, Tobias, J H, Evans, D M & Rivadeneira, F 2018, ' Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects ', American Journal of Human Genetics, vol. 102, no. 1, pp. 88-102 . https://doi.org/10.1016/j.ajhg.2017.12.005
American Journal of Human Genetics, 102(1), 88-102
Medina-Gomez, C, Kemp, J P, Trajanoska, K, Luan, J, Chesi, A, Ahluwalia, T S, Mook-Kanamori, D O, Ham, A, Hartwig, F P, Evans, D S, Joro, R, Nedeljkovic, I, Zheng, H F, Zhu, K, Atalay, M, Liu, C T, Nethander, M, Broer, L, Porleifsson, G, Mullin, B H, Handelman, S K, Nalls, M A, Jessen, L E, Heppe, D H M, Richards, J B, Wang, C, Chawes, B, Schraut, K E, Amin, N, Wareham, N, Karasik, D, Van der Velde, N, Ikram, M A, Zemel, B S, Zhou, Y, Carlsson, C J, Liu, Y, McGuigan, F E, Boer, C G, Bønnelykke, K, Ralston, S H, Robbins, J A, Walsh, J P, Zillikens, M C, Langenberg, C, Li-Gao, R, Williams, F M K, Harris, T B, Akesson, K, Jackson, R D, Sigurdsson, G, den Heijer, M, van der Eerden, B C J, van de Peppel, J, Spector, T D, Pennell, C, Horta, B L, Felix, J F, Zhao, J H, Wilson, S G, de Mutsert, R, Bisgaard, H, Styrkársdóttir, U, Jaddoe, V W, Orwoll, E, Lakka, T A, Scott, R, Grant, S F A, Lorentzon, M, van Duijn, C M, Wilson, J F, Stefansson, K, Psaty, B M, Kiel, D P, Ohlsson, C, Ntzani, E, van Wijnen, A J, Forgetta, V, Ghanbari, M, Logan, J G, Williams, G R, Bassett, J H D, Croucher, P I, Evangelou, E, Uitterlinden, A G, Ackert-Bicknell, C L, Tobias, J H, Evans, D M & Rivadeneira, F 2018, ' Life-course genome-wide association study meta-analysis of total body BMD and assessment of age-specific effects ', American Journal of Human Genetics, vol. 102, no. 1, pp. 88-102 . https://doi.org/10.1016/j.ajhg.2017.12.005
American journal of human genetics, 102(1), 88-102. Cell Press
American journal of human genetics, vol 102, iss 1
American Journal of Human Genetics
The American Journal of Human Genetics
American Journal of Human Genetics, 102(1), 88-102. Cell Press
Medina-Gomez, C, Kemp, J P, Trajanoska, K, Luan, J, Chesi, A, Ahluwalia, T S, Mook-Kanamori, D O, Ham, A, Hartwig, F P, Evans, D S, Joro, R, Nedeljkovic, I, Zheng, H-F, Zhu, K, Atalay, M, Liu, C-T, Nethander, M, Broer, L, Porleifsson, G, Mullin, B H, Handelman, S K, Nalls, M A, Jessen, L E, Heppe, D H M, Richards, J B, Wang, C, Chawes, B, Schraut, K E, Amin, N, Wareham, N, Karasik, D, Van der Velde, N, Ikram, M A, Zemel, B S, Zhou, Y, Carlsson, C J, Liu, Y, McGuigan, F E, Boer, C G, Bønnelykke, K, Ralston, S H, Robbins, J A, Walsh, J P, Zillikens, M C, Langenberg, C, Li-Gao, R, Williams, F M K, Harris, T B, Akesson, K, Jackson, R D, Sigurdsson, G, den Heijer, M, van der Eerden, B C J, van de Peppel, J, Spector, T D, Pennell, C, Horta, B L, Felix, J F, Zhao, J H, Wilson, S G, de Mutsert, R, Bisgaard, H, Styrkársdóttir, U, Jaddoe, V W, Orwoll, E, Lakka, T A, Scott, R, Grant, S F A, Lorentzon, M, van Duijn, C M, Wilson, J F, Stefansson, K, Psaty, B M, Kiel, D P, Ohlsson, C, Ntzani, E, van Wijnen, A J, Forgetta, V, Ghanbari, M, Logan, J G, Williams, G R, Bassett, J H D, Croucher, P I, Evangelou, E, Uitterlinden, A G, Ackert-Bicknell, C L, Tobias, J H, Evans, D M & Rivadeneira, F 2018, ' Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects ', American Journal of Human Genetics, vol. 102, no. 1, pp. 88-102 . https://doi.org/10.1016/j.ajhg.2017.12.005
American Journal of Human Genetics, 102(1), 88-102
Medina-Gomez, C, Kemp, J P, Trajanoska, K, Luan, J, Chesi, A, Ahluwalia, T S, Mook-Kanamori, D O, Ham, A, Hartwig, F P, Evans, D S, Joro, R, Nedeljkovic, I, Zheng, H F, Zhu, K, Atalay, M, Liu, C T, Nethander, M, Broer, L, Porleifsson, G, Mullin, B H, Handelman, S K, Nalls, M A, Jessen, L E, Heppe, D H M, Richards, J B, Wang, C, Chawes, B, Schraut, K E, Amin, N, Wareham, N, Karasik, D, Van der Velde, N, Ikram, M A, Zemel, B S, Zhou, Y, Carlsson, C J, Liu, Y, McGuigan, F E, Boer, C G, Bønnelykke, K, Ralston, S H, Robbins, J A, Walsh, J P, Zillikens, M C, Langenberg, C, Li-Gao, R, Williams, F M K, Harris, T B, Akesson, K, Jackson, R D, Sigurdsson, G, den Heijer, M, van der Eerden, B C J, van de Peppel, J, Spector, T D, Pennell, C, Horta, B L, Felix, J F, Zhao, J H, Wilson, S G, de Mutsert, R, Bisgaard, H, Styrkársdóttir, U, Jaddoe, V W, Orwoll, E, Lakka, T A, Scott, R, Grant, S F A, Lorentzon, M, van Duijn, C M, Wilson, J F, Stefansson, K, Psaty, B M, Kiel, D P, Ohlsson, C, Ntzani, E, van Wijnen, A J, Forgetta, V, Ghanbari, M, Logan, J G, Williams, G R, Bassett, J H D, Croucher, P I, Evangelou, E, Uitterlinden, A G, Ackert-Bicknell, C L, Tobias, J H, Evans, D M & Rivadeneira, F 2018, ' Life-course genome-wide association study meta-analysis of total body BMD and assessment of age-specific effects ', American Journal of Human Genetics, vol. 102, no. 1, pp. 88-102 . https://doi.org/10.1016/j.ajhg.2017.12.005
American journal of human genetics, 102(1), 88-102. Cell Press
American journal of human genetics, vol 102, iss 1
American Journal of Human Genetics
The American Journal of Human Genetics
Bone mineral density (BMD) assessed by DXA is used to evaluate bone health. In children, total body (TB) measurements are commonly used; in older individuals, BMD at the lumbar spine (LS) and femoral neck (FN) is used to diagnose osteoporosis. To dat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b60b7569222ea6cc4380b291e264b6d7
https://research.vumc.nl/en/publications/b47f10ea-5069-4e9c-80bd-d202f4dfe7f3
https://research.vumc.nl/en/publications/b47f10ea-5069-4e9c-80bd-d202f4dfe7f3
Autor:
Catherine M. Stein, Larry S. Schlesinger, Abul K. Azad, Maciej Pietrzak, Katherine Hartmann, Audrey C. Papp, Amanda C. de C. Williams, Wolfgang Sadee, Robert P. Igo, Samuel K. Handelman
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0198221 (2018)
PLoS ONE
PLoS ONE
Human alveolar macrophages (HAM) are primary bacterial niche and immune response cells during Mycobacterium tuberculosis (M.tb) infection, and human blood monocyte-derived macrophages (MDM) are a model for investigating M.tb-macrophage interactions.
Autor:
Samuel K. Handelman, Michal Seweryn, Maciej Pietrzak, Wolfgang Sadee, Grzegorz A. Rempala, Katherine Hartmann
Publikováno v:
Human Genetics. 133:1199-1215
Genetic factors strongly influence risk of common human diseases and treatment outcomes but the causative variants remain largely unknown; this gap has been called the ‘missing heritability’. We propose several hypotheses that in combination have
Autor:
William E. Ackerman, Jesse J. Kwiek, Igor O. Voronkin, Megan Mefford, Samuel K. Handelman, Jose A. Bazan, Victor Mwapasa, Daniel Janies, Jessica M. Mates, Surender B. Kumar
Publikováno v:
AIDS Research and Human Retroviruses. 30:102-112
Approximately 20% of all HIV-1 mother-to-child transmission (MTCT) occurs in utero (IU). In a chronic HIV infection, HIV-1 exists as a complex swarm of genetic variants, and following IU MTCT, viral genomic diversity is restricted through a mechanism
Publikováno v:
BMC Genomics. 17
Publikováno v:
BMC Genomics
Background Alterations in gene expression are key events in disease etiology and risk. Poor reproducibility in detecting differentially expressed genes across studies suggests individual genes may not be sufficiently informative for complex diseases,
Autor:
Elizabeth K. Speliotes, Yanhua Chen, Samuel K. Handelman, Xiaomeng Du, Brian D. Halligan, Vincent L. Chen
Publikováno v:
Gastroenterology. 156:S-1222
Publikováno v:
Cladistics. 29:560-566
It has been proposed that supertree approaches should be applied to large multilocus datasets to achieve computational tractability. Large datasets such as those derived from phylogenomics studies can be broken into many locus-specific tree searches