Zobrazeno 21 - 30
of 32
pro vyhledávání: '"Samir H. Barghout"'
Autor:
Mark D. Minden, Neil MacLean, Steven M. Chan, Sanduni Liyanagae, Sara Mirali, Changjiang Xu, James R. Hawley, Samir H. Barghout, Rashim Pal Singh, Elias Orouji, Aaron D. Schimmer, Xiaoming Wang, Gary D. Bader, Marcela Gronda, Dilshad H. Khan, Joelle Soriano, Mathieu Lupien, Veronique Voisin, Yulia Jitkova, Danny V. Jeyaraju, Geethu E. Thomas, David Sharon, Adina Borenstein, Rose Hurren, Ayesh K. Seneviratene, Andrea Arruda
Publikováno v:
Cell Stem Cell. 26:926-937.e10
Leukemic stem cells (LSCs) rely on oxidative metabolism and are differentially sensitive to targeting mitochondrial pathways, which spares normal hematopoietic cells. A subset of mitochondrial proteins is folded in the intermembrane space via the mit
Autor:
Anna Rydlewski, Jaime O. Claudio, Karen Yee, Andre C. Schuh, Aaron D. Schimmer, Mahadeo A. Sukhai, Sanduni U. Liyanage, Thirushi P. Siriwardena, Mark D. Minden, Rose Hurren, Dawn Maze, Samir H. Barghout, Steven M. Chan, Amr Rostom, Hassan Sibai, Emily Heath, Dina Khalaf, Vikas Gupta, Marcela Gronda, Tracy Stockley, Tong Zhang, Andrzej Lutynski, Simon Kavanagh, Suzanne Kamel-Reid
Publikováno v:
Leukemia research. 68
We evaluated outcomes of 100 patients with high risk AML treated with Ida-FLAG induction as first-line therapy. 72 achieved remission with one cycle; 19 did not. High risk cytogenetics and TP53 mutations were associated with failure to achieve remiss
Autor:
Samir H. Barghout, Aaron D. Schimmer
Publikováno v:
Oncotarget
Autor:
Mark D. Minden, Michael Andreeff, Rose Hurren, Mark Mabanglo, Marcela Gronda, Neil MacLean, Gautam Borthakur, Lauren Heese, Takenobu Nii, Martin Stogniew, Ran Zhao, Keith Wong, Aaron D. Schimmer, Emil F. Pai, Jo Ishizawa, Jonathan St-Germain, Ondrej Halgas, Wencai Ma, Hagop M. Kantarjian, Vivian Ruvolo, Samir H. Barghout, Andrew B. Leber, Walid Houry, Grace Egan, Yuki Nishida, Yulia Jitkova, R. Eric Davis, Brian Raught, Todd M. Link, Kensuke Kojima, John Man Chun Ma, Sarah F. Zarabi
Publikováno v:
Cancer Research. 79:2720-2720
ClpP is a mitochondrial protease and a major protein quality control mediator that primarily interacts with metabolic enzymes in mitochondria. Here, we demonstrate that activation of this protease results in prominent anti-cancer activity, and propos
Autor:
John E. Dick, Xiaoming Wang, Neil MacLean, Mark D. Minden, Samir H. Barghout, Rose Hurren, Dilshad H. Khan, Aaron D. Schimmer, Steven M. Chan, Yulia Jitkova, Sanduni U. Liyanage, Veronique Voisin, David Sharon, Joelle Soriano, Rashim Pal Singh, Gary D. Bader, Changjiang Xu, Marcela Gronda, Danny V. Jeyaraju, Eric R. Lechman
Publikováno v:
Blood. 132:1339-1339
The majority of mitochondrial proteins are encoded in the nucleus, translated in the cytoplasm and imported into the mitochondria. A subset of cysteine-rich proteins destined for the mitochondrial intermembrane space are oxidized and folded by the Mi
Autor:
Zachary Blatman, Rose Hurren, Aaron D. Schimmer, Geethu E. Thomas, Samir H. Barghout, Neil MacLean, G. Wei Xu
Publikováno v:
Blood. 132:1350-1350
UBA1 is the major ubiquitin-activating enzyme that initiates the ubiquitylation cascade whereby proteins are tagged with mono- or polyubiquitin to mark them for proteasomal degradation or modify their functions. Despite having equal levels of UBA1 pr
Publikováno v:
Biochemical and biophysical research communications. 468(1-2)
Ovarian cancer is the fifth leading cause of cancer-related mortalities in women. Epithelial ovarian cancer (EOC) represents approximately 90% of all ovarian malignancies. Most EOC patients are diagnosed at advanced stages and current chemotherapy re
Autor:
Marcela Gronda, Mark D. Minden, Danny V. Jeyaraju, John E. Dick, Eric R. Lechman, Aaron D. Schimmer, Samir H. Barghout, Dilshad H. Khan, Changjiang Xu, Yulia Jitkova, Xiaoming Wang, Sanduni U. Liyanage, Joelle Soriano, David Sharon, Gary D. Bader, Veronique Voisin, Rose Hurren, Steven M. Chan, Neil MacLean
Publikováno v:
Blood. 130:881-881
The vast majority of mitochondrial proteins are encoded in the nucleus, translated in the cytoplasm and then imported into the mitochondria. A subset of these imported proteins are folded into their mature and functional forms in the mitochondrial in
Autor:
Rose Hurren, Mark D. Minden, Michael Milhollen, Neil MacLean, Danny V. Jeyaraju, Xiaoming Wang, Samir H. Barghout, Aaron D. Schimmer, G. Wei Xu, Marcela Gronda, Marc L. Hyer, Michael Sintchak, Parasvi S. Patel, Simon Kavanagh, Tary Traore, Allison Berger, Razq Hakem
Publikováno v:
Blood. 130:814-814
Introduction: Ubiquitin-like Modifier Activating Enzyme 1 (UBA1; UAE) is the initiating enzyme in the ubiquitylation cascade in which proteins are tagged with ubiquitin moieties to regulate their degradation or function. Compared to normal hematopoie
Autor:
Yang Xin Fu, Lynne-Marie Postovit, Samir H. Barghout, Christine Yang, Abul K. Azad, Nubia Zepeda, Helen Steed, Krista Vincent, Zhihua Xu
Publikováno v:
Gynecologic oncology. 138(3)
Objective Resistance to platinum-based therapeutic agents represents a major hurdle in the treatment of epithelial ovarian cancer (EOC). There is an urgent need to better understand the underlying mechanisms. Here, we investigated the role of RUNX3 i