Zobrazeno 91 - 100
of 145
pro vyhledávání: '"Sally, John"'
Publikováno v:
Arthritis and rheumatism. 52(3)
Objective Recent studies of 2 complex diseases, rheumatoid arthritis (RA) and Crohn's disease (CD), showed associations with genes mapping to the cytokine gene cluster on 5q31. In particular, a functional single-nucleotide polymorphism (SNP) mapping
Autor:
Anne Barton, Sally John, W. E. R. Ollier, Clive Hawkins, D Ward, Anne Hinks, Stephen Eyre, J Worthington, Anthony A. Fryer, Richard C. Strange, John Woolmore
Publikováno v:
Brain : a journal of neurology. 127(Pt 8)
Twin, family and adoption studies suggest that susceptibility to multiple sclerosis is substantially mediated by genetic factors. Linkage to human chromosome 17q, homologous to a locus linked to experimental animal models of multiple sclerosis, has b
Autor:
William Brintnell, Neil Shephard, William E R Ollier, Anne Hinks, Sally John, Alan J. Silman, Stephen Eyre, Paul Wordsworth, K MacKay, Anne Barton, Jane Worthington
Publikováno v:
Arthritis and rheumatism. 50(3)
Objective A previous whole-genome scan (WGS) of 182 UK rheumatoid arthritis (RA) affected sibling pair (ASP) families suggested linkage to HLA and 11 other chromosome regions. Replication of such findings in an independent cohort can help to distingu
Autor:
Neil James Gibson, Sally John, Anne Barton, Tracy Mills, Jane Worthington, Alan J. Silman, Giulia C. Kennedy, Wenwei Chen, Guoying Liu, Eleftheria Zeggini, Neil Shephard, Manqiu Cao, Nisha Vasavda, Steve Eyre, Keith W. Jones, Anne Hinks, William E R Ollier
Publikováno v:
American journal of human genetics. 75(1)
Despite the theoretical evidence of the utility of single-nucleotide polymorphisms (SNPs) for linkage analysis, no whole-genome scans of a complex disease have yet been published to directly compare SNPs with microsatellites. Here, we describe a whol
Autor:
David W. Ray, Adam Stevens, Sally John, Christopher E.M. Griffiths, Rachelle Donn, Eleftheria Zeggini, Helen L. Richards
Publikováno v:
The Journal of clinical endocrinology and metabolism. 89(2)
Differences in glucocorticoid (GC) sensitivity may underlie both common diseases (e.g. hypertension) and variability in response to treatment with GCs (e.g. asthma). We tested the potential involvement of the GC receptor (GR) gene in mediating GC sen
Autor:
Sally John, Gary Smalley
With her Marine husband serving overseas, will Jenna trust God's plans for their marriage--or find comfort in another's arms?Jenna Beaumont Mason had her marriage all planned out. But what she didn't plan was her husband, Kevin, unexpectedly reenlist
Autor:
Deborah P M Symmons, Alan J. Silman, Simon Smith, Anne Barton, Jane Worthington, Jonathan F. Morrison, Sally John
Publikováno v:
Arthritis and rheumatism. 48(12)
Autor:
Katrina J Scurrah, Shaoqi Rao, W. James Gauderman, Taesung Park, Stuart MacGregor, Shelley B. Bull, Martin D. Tobin, Sally John, Dai Wang, Laurent Briollais
Publikováno v:
Genetic epidemiology. 25
Longitudinal family studies provide a valuable resource for investigating genetic and environmental factors that influence long-term averages and changes over time in a complex trait. This paper summarizes 13 contributions to Genetic Analysis Worksho
Autor:
Neil Shephard, Philip Chapman, Sally John, Andrew Pickles, Milena Falcaro, Anne Hinks, Eleftheria Zeggini, Anne Barton, Jane Worthington
Publikováno v:
Scopus-Elsevier
BMC Genetics
BMC Genetics
BACKGROUND: The design of appropriate strategies to analyze and interpret linkage results for complex human diseases constitutes a challenge. Parameters such as power, definition of phenotype, and replicability have to be taken into account in order
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::098571ddfee0633353fad092f2ebe35c
https://researchonline.lshtm.ac.uk/id/eprint/1919/1/1471-2156-4-S1-S26.pdf
https://researchonline.lshtm.ac.uk/id/eprint/1919/1/1471-2156-4-S1-S26.pdf
Autor:
Jenny Barrett, John C. Bell, Sally John, Stephen Eyre, D Lee, Anita Milicic, Anne Myerscough, Sarah White, William E R Ollier, Anne Barton, Jane Worthington, Alan J. Silman, Paul Wordsworth, S. Laval, Matthew A. Brown, K MacKay
Publikováno v:
Arthritis and rheumatism. 46(3)
Objective To undertake a systematic whole-genome screen to identify regions exhibiting genetic linkage to rheumatoid arthritis (RA). Methods Two hundred fifty-two RA-affected sibling pairs from 182 UK families were genotyped using 365 highly informat