Zobrazeno 71 - 80
of 205
pro vyhledávání: '"Ross C. Donehower"'
Autor:
Scott H. Kaufmann, Eric K. Rowinsky, Louise B. Grochow, William Slichenmyer, Ross C. Donehower
Publikováno v:
Cancer Chemotherapy and Pharmacology. 34:S53-S57
The camptothecin analogues topotecan and irinotecan (CPT-11) are active anticancer drugs. This article reviews the accumulated results of clinical and laboratory studies performed with these agents at The Johns Hopkins Oncology Center. In a phase I c
Autor:
Louise B. Grochow, David S. Ettinger, Mary Duerr, Jane M. Borkowski, Eric K. Rowinsky, Ross C. Donehower, Tian Ling Chen
Publikováno v:
Cancer Chemotherapy and Pharmacology. 33:493-496
Aging influences the disposition and effects of several classes of drugs. Although drug clearance rate is correlated with toxicity for many anticancer drugs, few data have been published concerning the relationship of aging and clearance of chemother
Autor:
Dung T. Le, Daniel A. Laheru, David Cosgrove, Lei Zheng, Katharine Kinsman, Edna I. Flores, Ki Y. Chung, Ana De Jesus-Acosta, Luis A. Diaz, Amanda L. Blackford, Ross C. Donehower, George R. Oliver, Lalan S. Wilfong
Publikováno v:
Cancer Chemotherapy and Pharmacology
Purpose Studies treating adenocarcinoma of the pancreas with gemcitabine alone or in combination with a doublet have demonstrated modest improvements in survival. Recent reports have suggested that using the triple-drug regimen FOLFIRINOX can substan
Autor:
John M. Kirkwood, Ross C. Donehower
Publikováno v:
Current Opinion in Oncology. 5:1001-1004
Autor:
Eric K. Rowinsky, Ross C. Donehower
Publikováno v:
Cancer Treatment Reviews. 19:63-78
TAXOL (paclitaxel) is a unique new antineoplastic agent that has generated a considerable amount of scientific interest from many disciplines since it entered clinical trials in the early 1980s. There are a number of reasons for this interest. The na
Publikováno v:
JNCI Journal of the National Cancer Institute. 85:271-291
The nuclear enzyme topoisomerase I (topo I) has been recently recognized as the target for the anticancer drug camptothecin (CPT) and its derivatives. Two of the agents that target this enzyme--topotecan (TPT) and CPT-11--appear to be active against
Autor:
Daniel A. Laheru, Anirban Maitra, Alison P. Klein, Ana De Jesus-Acosta, Ralph H. Hruban, Maria Cristina Villarroel, Manuel Hidalgo, N. V. Rajeshkumar, Siân Jones, Ross C. Donehower, James R. Eshleman, Ignacio Garrido-Laguna
Publikováno v:
Molecular cancer therapeutics. 10(1)
Metastasis and drug resistance are the major causes of mortality in patients with pancreatic cancer. Once developed, the progression of pancreatic cancer metastasis is virtually unstoppable with current therapies. Here, we report the remarkable clini
Autor:
Kathleen M. Murphy, Daniel A. Laheru, Antonio Jimeno, Manuel Hidalgo, Colin D. Weekes, Sharyn D. Baker, Ross C. Donehower, Sujatha Nallapareddy, Michelle A. Rudek, Wells A. Messersmith, Alexis Norris-Kirby
Purpose The primary aim of this study was to characterize the 6-month overall survival and toxicity associated with second-line capecitabine treatment of advanced pancreatic cancer patients harboring the TYMS *2/*2 allele. The secondary aim was to an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75cacc10a499bf29916fef72963295ad
https://europepmc.org/articles/PMC3110647/
https://europepmc.org/articles/PMC3110647/
Publikováno v:
Journal of the National Cancer Institute. 101(18)
Autor:
Ross C. Donehower, Eric K. Rowinsky
Publikováno v:
Pharmacology & Therapeutics. 52:35-84
Although there has been a rapid expansion of the number of classes of compounds with antineoplastic activity, few have played a more vital role in the curative and palliative treatment of cancers than the antimicrotubule agents. Although the vinca al