Zobrazeno 41 - 50
of 126
pro vyhledávání: '"Robert F. Paulson"'
Autor:
Lindsay Snyder, Margherita T. Cantorna, Pamela A. Hankey-Giblin, Yuan Tian, Limin Zhang, Andrew D. Patterson, James Fraser, Robert F. Paulson, Adwitia Dey, Joselyn N. Allen
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 9 (2018)
Frontiers in Immunology, Vol 9 (2018)
Neurodegeneration is a critical problem in aging populations and is characterized by severe central nervous system (CNS) inflammation. Macrophages closely regulate inflammation in the CNS and periphery by taking on different activation states. The so
Autor:
Robert F. Paulson, Sunduz Keles, Emery H. Bresnick, Kyle J. Hewitt, Charu Mehta, Kirby D. Johnson
Publikováno v:
Development. 145
Hemoglobin-expressing erythrocytes (red blood cells) act as fundamental metabolic regulators by providing oxygen to cells and tissues throughout the body. Whereas the vital requirement for oxygen to support metabolically active cells and tissues is w
Publikováno v:
Erythropoiesis ISBN: 9781493974276
Bone marrow steady-state erythropoiesis maintains erythroid homeostasis throughout life. This process constantly generates new erythrocytes to replace the senescent erythrocytes that are removed by macrophages in the spleen. In contrast, anemic or hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73ffa2ef3be27943049478bebb96e0b2
https://doi.org/10.1007/978-1-4939-7428-3_5
https://doi.org/10.1007/978-1-4939-7428-3_5
Autor:
Joshua J. Coon, Nobuyuki Tanimura, Koichi R. Katsumura, Daniel R. Matson, Kyle J. Hewitt, Emery H. Bresnick, Prithvia Devadas, Sunduz Keles, Alexander S. Hebert, Siyang Hao, Jin-Soo Kim, Colin N. Dewey, Robert F. Paulson
An enhancer with amalgamated E-box and GATA motifs (+9.5) controls expression of the regulator of hematopoiesis GATA-2. While similar GATA-2-occupied elements are common in the genome, occupancy does not predict function, and GATA-2-dependent genetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7bb662254d2c3bd7437d4e7b3f978dd
https://europepmc.org/articles/PMC5578808/
https://europepmc.org/articles/PMC5578808/
Autor:
Bradley A. Carlson, Mary J. Kennett, K. Sandeep Prabhu, Chang Liao, Robert F. Paulson, Ross C. Hardison
Publikováno v:
Blood. 131(23)
Micronutrient selenium (Se) plays a key role in redox regulation through its incorporation into selenoproteins as the 21st amino acid selenocysteine (Sec). Because Se deficiency appears to be a cofactor in the anemia associated with chronic inflammat
Autor:
Robert F. Paulson, Laura L. Goodfield, Diwakar Bastihalli Tukaramrao, Michael D. Quickel, K. Sandeep Prabhu, Emily R. Finch
Supplementation with nontoxic doses of micronutrient selenium has been shown to alleviate chronic myelogenous leukemia (CML) via the elimination of leukemia stem cells (LSCs) in mice. This treatment provides a new and novel method for eliminating the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b37d0f6d9ea8ea38dcade20f1d62880
https://europepmc.org/articles/PMC5374288/
https://europepmc.org/articles/PMC5374288/
Cancer is a complex disease where cancer stem cells (CSCs) maintain unlimited replicative potential, but evade chemotherapy drugs through cellular quiescence. CSCs are able to give rise to bulk tumor cells that have the capability to override anti-pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37d5915e27ae0f865d8e4a641fda443d
https://doi.org/10.1016/bs.acr.2017.07.003
https://doi.org/10.1016/bs.acr.2017.07.003
Autor:
Emily R. Finch, Naveen Kaushal, Shailaja Hegde, Robert F. Paulson, Ujjawal H. Gandhi, Avinash K. Kudva, Craig T. Jordan, Mary J. Kennett, K. Sandeep Prabhu
Publikováno v:
Cancer Research. 74:3890-3901
Eradicating cancer stem-like cells (CSC) may be essential to fully eradicate cancer. Metabolic changes in CSC could hold a key to their targeting. Here, we report that the dietary micronutrient selenium can trigger apoptosis of CSC derived from chron
Autor:
Chen Wang, Lucy R. Osborne, Monica L. Bailey, Robert F. Paulson, William L. Stanford, Ann M. Flenniken, Mark D. Minden, Nicole M. Anderson, Kelly M. McNagny, Janet Rossant, Elizabeth S. L. Berndl, Zorana Berberovic, Dwayne L. Barber, S. Lee Adamson
Publikováno v:
Experimental Hematology. 40:48-60
The ability of random mutagenesis techniques to annotate the mammalian genome can be hampered due to genetic redundancy and compensatory pathways that mask heterozygous mutations under homeostatic conditions. The objective of this study was to devise
Autor:
Shailaja Hegde, John P. Vanden Heuvel, Mary J. Kennett, K. Sandeep Prabhu, Robert F. Paulson, Kodihalli C. Ravindra, Pamela A. Hankey, Kelsey T. Hafer, Naveen Kaushal, Jerry T. Thompson, Ujjawal H. Gandhi, Christopher R. Chiaro
Publikováno v:
Blood. 118:6909-6919
Targeting cancer stem cells is of paramount importance in successfully preventing cancer relapse. Recently, in silico screening of public gene-expression datasets identified cyclooxygenase-derived cyclopentenone prostaglandins (CyPGs) as likely agent