Zobrazeno 61 - 70
of 132
pro vyhledávání: '"Rima Al-awar"'
Autor:
Adele Girgis-Gabardo, Anna Dvorkin-Gheva, Methvin Isaac, Kwang H. Kim, Rima Al-awar, Mirza S. Shakeel, Emily Ford, Craig Aarts, William D. Gwynne, John A. Hassell
Publikováno v:
BMC Cancer
BMC Cancer, Vol 20, Iss 1, Pp 1-17 (2020)
BMC Cancer, Vol 20, Iss 1, Pp 1-17 (2020)
Background Breast tumor initiating cells (BTIC) are stem-like cells that initiate and sustain tumor growth, and drive disease recurrence. Identifying therapies targeting BTIC has been hindered due primarily to their scarcity in tumors. We previously
Autor:
Yousef Najajreh, James Koropatnnick, Rima Al-awar, Richard Marcellus, Stephen Ritter, Methvin Isaac, Brian H. Shilton, M. Vincent, Mohammed Mohammed, Peter J. Ferguson
Publikováno v:
Cancer Research. 81:PO-039
Despite the innovations in chemotherapeutic treatment of pancreatic cancer, the generally poor outcome of this disease begs the search for novel targets. RAD51 is a critical component of homologous recombination DNA repair, binding with BRCA2 and for
Autor:
Gennady Poda, Marko Jakopović, Levon Halabelian, Methvin Isaac, Nikolina Radulovich, Michael Prakesch, Caroline Huard, Ahmed Aman, Dhananjay Joshi, Zhong Yao, Manuel Chan, Wiebke Schormann, Richard Marcellus, Babu Joseph, Rima Al-awar, Luka Drecun, Mohammed Mohammed, Li Niu, Brigitte L. Thériault, María Sánchez-Osuna, David Uehling, Ahmed Mamai, Ming-Sound Tsao, Jasmin Coulombe-Huntington, Taira Kiyota, Evelyne Lima-Fernandes, Punit Saraon, Ankit Rai, Jamie Snider, David W. Andrews, Cheryl H. Arrowsmith, Farzaneh Aboualizadeh, Natasha B. Leighl, Miroslav Samaržija, Victoria Wong, Anna Lyakisheva, Mike Tyers, Ratheesh Subramanian, Adrian G. Sacher, Fengling Li, Masoud Vedadi, Igor Stagljar, Shivanthy Pathmanathan
Publikováno v:
Journal of Molecular Biology. 433:167294
Activating mutations in the epidermal growth factor receptor (EGFR) are common driver mutations in non-small cell lung cancer (NSCLC). First, second and third generation EGFR tyrosine kinase inhibitors (TKIs) are effective at inhibiting mutant EGFR N
Publikováno v:
Cancer Research. 81:1222-1222
Lung cancer is the most lethal cancer globally, accounting for 1.8 million deaths in 2018. Presently, there is a need for novel targets for the development of improved therapeutics. Data mining through genetic screens suggested that Cell Division Cyc
Publikováno v:
Biomaterials. 123:39-47
We developed a novel taxane-binding peptide (TBP) modified, biodegradable polymeric micelle that overcomes limitations of drug loading and poor serum stability typically seen with particle delivery, leading to enhanced pharmacokinetics and tumor dist
Autor:
Benjamin G. Neel, Laudine Communal, Kevin R. Brown, Fernando Suarez Saiz, Sasha A. Doodnauth, Mauricio Medrano, Marian Novak, Rima Al-awar, Marcin P. Iwanicki, Jane Cullis, John Douglas Mcpherson, Robert Rottapel, Fabrice Sircoulomb, Josee Normand, Joshua Paterson, Anne Marie Mes-Massons, Laurie Ailles, Paul M. Krzyzanowski, Ronny Drapkin
Publikováno v:
Cell Reports, Vol 18, Iss 10, Pp 2343-2358 (2017)
The degree of genetic aberrations characteristic of high-grade serous ovarian cancer (HGSC) makes identification of the molecular features that drive tumor progression difficult. Here, we perform genome-wide RNAi screens and comprehensive expression
Autor:
Janet Rossant, Trevor D. McKee, Rima Al-awar, Ahmed Aman, Richard Marcellus, Sean E. Egan, Amanda J. Loch, Christine E.B. Jo, Jessica R. Adams, David Uehling, Christopher Fladd, Lamis Hammoud
Publikováno v:
Stem Cell Reports, Vol 7, Iss 4, Pp 787-801 (2016)
Stem Cell Reports
Stem Cell Reports
Summary Blood vessels are formed through vasculogenesis, followed by remodeling of the endothelial network through angiogenesis. Many events that occur during embryonic vascular development are recapitulated during adult neoangiogenesis, which is cri
Autor:
Mathieu Lupien, Yulia Jitkova, Michael Mullokandov, Helen Loo Yau, Rima Al-awar, James R. Hawley, Rose Hurren, Troy Ketela, S. Kim, Veronique Voisin, Neil MacLean, Daniel D. De Carvalho, Mark D. Minden, Geethu E. Thomas, Val A. Fajardo, Ahmed Aman, Zhenyue Hao, Zaza Khuchua, G. Wei Xu, Gary D. Bader, Richard P. Bazinet, Juan J. Aristizabal Henao, Mingjing Xu, Paul J. LeBlanc, Ayesh K. Seneviratne, Steven M. Claypool, Steven M. Chan, Xiaoming Wang, Atan Gross, Aaron D. Schimmer, Ken D. Stark, David Sharon, Raphaël Chouinard-Watkins, Danny V. Jeyaraju, Caitlin Schafer, Marcela Gronda
Summary Tafazzin (TAZ) is a mitochondrial transacylase that remodels the mitochondrial cardiolipin into its mature form. Through a CRISPR screen, we identified TAZ as necessary for the growth and viability of acute myeloid leukemia (AML) cells. Genet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43b74e60e809d7c98db8697836fef410
https://europepmc.org/articles/PMC7137093/
https://europepmc.org/articles/PMC7137093/
Autor:
Rima Al-awar, David Uehling, Babu Joseph, Sheng Li, Jose M. Paredes, Tatyana Mamonova, Angel Orte, Kunhong Xiao, W. Bruce Sneddon, Qiangmin Zhang, Peter A. Friedman, Jennifer McGarvey, Hongda Liu, Frederic Jean-Alphonse, Dawei Wang
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2019, 294 (12), pp.4546-4571. ⟨10.1074/jbc.RA119.007421⟩
Journal of Biological Chemistry 12 (294), 4546-4571. (2019)
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2019, 294 (12), pp.4546-4571. ⟨10.1074/jbc.RA119.007421⟩
Journal of Biological Chemistry 12 (294), 4546-4571. (2019)
International audience; Na+-H+ exchanger regulatory factor-1 (NHERF1) is a PDZ protein that scaffolds membrane proteins, including sodium-phosphate co-transport protein 2A (NPT2A) at the plasma membrane. NHERF1 is a phosphoprotein with 40 Ser and Thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02b17dad0646bc6ce03f297a21ee2571
https://hal.inrae.fr/hal-02628955
https://hal.inrae.fr/hal-02628955
Autor:
Stéphane Richard, Cheryl H. Arrowsmith, Hiroshi Nara, Carlo C. dela Seña, Shinji Takagi, Carlos Zepeda, Rima Al-awar, Yoshinori Ishikawa, Dalia Barsyte-Lovejoy, David Macleod, Shawna Organ, Suzanne Ackloo, Peter Brown, Fengling Li, Tsukasa Sugo, Masoud Vedadi, Nozomu Sakai, David Dilworth, Mohammad S. Eram, Hideto Fukushi, Kozo Hayashi, Magdalena M. Szewczyk, Masayuki Takizawa, Rachel Harding
Protein arginine methyltransferases (PRMTs) regulate diverse biological processes and are increasingly being recognized for their potential as drug targets. Here we report the discovery of a potent, selective and cell active chemical probe for PRMT7.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4c9043a776a3a8617cea30f4df76e60