Zobrazeno 11 - 20
of 226
pro vyhledávání: '"Richard H. Gomer"'
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Fibrosis involves increasing amounts of scar tissue appearing in a tissue, but what drives this is unclear. In fibrotic lesions in human and mouse lungs, we found extensive desialylation of glycoconjugates, and upregulation of sialidases. Th
Externí odkaz:
https://doaj.org/article/256a03a648894ef7bd5c3c950dca5d67
Publikováno v:
BMC Immunology, Vol 18, Iss 1, Pp 1-15 (2017)
Abstract Background Circulating bone marrow-derived monocytes can leave the blood, enter a tissue, and differentiate into M1 inflammatory, M2a remodeling/fibrotic, or M2c/Mreg resolving/immune-regulatory macrophages. Macrophages can also convert from
Externí odkaz:
https://doaj.org/article/c863dd59857e4551b6dc6f4d48aa62fe
Publikováno v:
mBio, Vol 10, Iss 2 (2019)
ABSTRACT In patients with invasive fungal diseases, there is often little cellular inflammatory response. We tested the idea that binding of the human constitutive plasma protein serum amyloid P component (SAP) (also called PTX2) to Candida albicans
Externí odkaz:
https://doaj.org/article/1ea2f576f2934cb5bbd422741840512d
Autor:
Darrell Pilling, Richard H. Gomer
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Pentraxins such as serum amyloid P (SAP; also known as PTX2) regulate several aspects of the innate immune system. SAP inhibits the differentiation of monocyte-derived fibroblast-like cells called fibrocytes, promotes the formation of immuno-regulato
Externí odkaz:
https://doaj.org/article/f6a478d154be424e946490417019d416
Autor:
Yu Tang, Yuantai Wu, Sarah E. Herlihy, Francisco J. Brito-Aleman, Jose H. Ting, Chris Janetopoulos, Richard H. Gomer
Publikováno v:
mBio, Vol 9, Iss 1 (2018)
ABSTRACT In eukaryotic microbes, little is known about signals that inhibit the proliferation of the cells that secrete the signal, and little is known about signals (chemorepellents) that cause cells to move away from the source of the signal. Autoc
Externí odkaz:
https://doaj.org/article/7addfcf8d05948fa8ec34887df7d8be0
Autor:
Jonathan E. Phillips, Richard H. Gomer
Publikováno v:
Disease Models & Mechanisms, Vol 8, Iss 2, Pp 147-156 (2015)
Neuronal ceroid lipofuscinosis (NCL) is the most common childhood-onset neurodegenerative disease. NCL is inevitably fatal, and there is currently no treatment available. Children with NCL show a progressive decline in movement, vision and mental abi
Externí odkaz:
https://doaj.org/article/2b5642a2ed7c4557815e0cc125702cbd
Publikováno v:
Communicative & Integrative Biology, Vol 2, Iss 4, Pp 293-297 (2009)
It is still not clear how organisms regulate the size of appendages or organs during development. During development, Dictyostelium discoideum cells form groups of ~2x104 cells. The cells secrete a protein complex called counting factor (CF) that all
Externí odkaz:
https://doaj.org/article/b0ea5782c10f4b229bf74d0ca31c4d22
Human macrophages and the eukaryotic microbeDictyostelium discoideumingest bacteria by phagocytosis, and then kill the ingested bacteria. Some pathogenic bacteria secrete linear chains of phosphate residues (polyphosphate; polyP), and the polyP cause
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4aabd32b6efc485b0fefa4811c12244
https://doi.org/10.1101/2023.05.03.539237
https://doi.org/10.1101/2023.05.03.539237
In human lung cells, the profibrotic cytokine TGF-β1 increases sialidase 3 (NEU3) protein by increasingNEU3translation without increasing levels ofNEU3mRNA. To elucidate how TGF-β1 regulates translation, we treated human lung fibroblasts (HLF) with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b08eb40cde99f37ef0a6636e96a1e431
https://doi.org/10.1101/2022.10.23.513405
https://doi.org/10.1101/2022.10.23.513405
Publikováno v:
Journal of Cell Science. 135
Dictyostelium discoideum is a unicellular eukaryote that eats bacteria, and eventually outgrows the bacteria. D. discoideum cells accumulate extracellular polyphosphate (polyP), and the polyP concentration increases as the local cell density increase