Zobrazeno 81 - 90
of 479
pro vyhledávání: '"Richard A, Koup"'
Autor:
Michelle C Crank, Ingelise J Gordon, Galina V Yamshchikov, Sandra Sitar, Zonghui Hu, Mary E Enama, LaSonji A Holman, Robert T Bailer, Melissa B Pearce, Richard A Koup, John R Mascola, Gary J Nabel, Terrence M Tumpey, Richard M Schwartz, Barney S Graham, Julie E Ledgerwood, VRC 308 Study Team
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0123969 (2015)
A novel, swine-origin influenza A (H1N1) virus was detected worldwide in April 2009, and the World Health Organization (WHO) declared a global pandemic that June. DNA vaccine priming improves responses to inactivated influenza vaccines. We describe t
Externí odkaz:
https://doaj.org/article/62c73a0d440b48668ce1c649806319e3
Autor:
Constantinos Petrovas, Giulia Fabozzi, Rafick-Pierre Sekaly, Alessandra Noto, Maria Maddalena Perra, Craig Fenwick, Giuseppe Pantaleo, Sanjana Shah, Alexander Chassiakos, Vasilis Papaioannou, Richard A. Koup, Daniel C. Douek, Kartika Padhan, David R. Ambrozak, Khader Ghneim, Eirini Moysi, Antigoni Poultsidi, Samuel Darko, Maria Ioannou
Publikováno v:
Proc Natl Acad Sci U S A
The development of follicular helper CD4 T (TFH) cells is a dynamic process resulting in a heterogenous pool of TFH subsets. However, the cellular and molecular determinants of this heterogeneity and the possible mechanistic links between them is not
Autor:
Katherine V, Houser, Grace L, Chen, Cristina, Carter, Michelle C, Crank, Thuy A, Nguyen, Maria Claudia, Burgos Florez, Nina M, Berkowitz, Floreliz, Mendoza, Cynthia Starr, Hendel, Ingelise J, Gordon, Emily E, Coates, Sandra, Vazquez, Judy, Stein, Christopher L, Case, Heather, Lawlor, Kevin, Carlton, Martin R, Gaudinski, Larisa, Strom, Amelia R, Hofstetter, C Jason, Liang, Sandeep, Narpala, Christian, Hatcher, Rebecca A, Gillespie, Adrian, Creanga, Masaru, Kanekiyo, Julie E, Raab, Sarah F, Andrews, Yi, Zhang, Eun Sung, Yang, Lingshu, Wang, Kwanyee, Leung, Wing-Pui, Kong, Alec W, Freyn, Raffael, Nachbagauer, Peter, Palese, Robert T, Bailer, Adrian B, McDermott, Richard A, Koup, Jason G, Gall, Frank, Arnold, John R, Mascola, Barney S, Graham, Julie E, Ledgerwood, Colin, Tran
Publikováno v:
Nature medicine. 28(2)
Currently, licensed seasonal influenza vaccines display variable vaccine effectiveness, and there remains a need for novel vaccine platforms capable of inducing broader responses against viral protein domains conserved among influenza subtypes. We co
Autor:
Nicole A. Doria-Rose, Cheng Cheng, Tyler Stephens, Shuishu Wang, Steven J. Chen, Peter D. Kwong, John Paul Todd, Christopher A. Gonelli, Amarendra Pegu, Sijy O'Dell, Richard A. Koup, Vrc Production Program, Kai Xu, Baoshan Zhang, John R. Mascola, Adrian B. McDermott, Hongying Duan, Jelle van Schooten, Li Ou, Jeffrey C. Boyington, Manjula Basappa, Angela R. Corrigan, Sarah O’Connell, Sandeep Narpala, Kathryn E. Foulds, Megan E. DeMouth, Marit J. van Gils, Yaroslav Tsybovsky, Tongqing Zhou, Hui Geng
Publikováno v:
Cell reports, 35(1):108937. Cell Press
Cell Reports, Vol 35, Iss 1, Pp 108937-(2021)
Cell reports
Cell Reports, Vol 35, Iss 1, Pp 108937-(2021)
Cell reports
SUMMARY Soluble “SOSIP”-stabilized envelope (Env) trimers are promising HIV-vaccine immunogens. However, they induce high-titer responses against the glycan-free trimer base, which is occluded on native virions. To delineate the effect on base re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c25456efa28d5031ea6efc66dceedf09
https://pure.amc.nl/en/publications/fusion-peptide-priming-reduces-immune-responses-to-hiv1-envelope-trimer-base(8874d9ca-be54-4482-9c96-b1171a7bdf93).html
https://pure.amc.nl/en/publications/fusion-peptide-priming-reduces-immune-responses-to-hiv1-envelope-trimer-base(8874d9ca-be54-4482-9c96-b1171a7bdf93).html
Autor:
Michael Chambers, Safiatou Doumbo, Sarah F. Andrews, Peter D. Crompton, Peter D. Sun, Eric O. Long, Shanping Li, Mary E. Peterson, Richard A. Koup, Boubacar Traore, Kristin L. Boswell, Adrian B. McDermott, Joshua Tan, Aissata Ongoiba, Kassoum Kayentao, Jinghua Lu, Kazutoyo Miura, Christopher M. Tipton, Ababacar Diouf, Carole A. Long, Padmapriya Sekar, Christine S. Hopp, Silvia Portugal, Jeff Skinner
Publikováno v:
The Journal of Experimental Medicine
The role of IgM in human malaria is unclear. In a cohort study in Mali, Hopp et al. find that malaria-specific memory B cells are disproportionally IgM in children, are activated during acute malaria, and produce IgM that inhibits malaria parasite gr
Publikováno v:
Methods. 154:118-124
Bispecific (bs) antibodies (Abs, bsAbs) are engineered immunoglobulins that contain two different antigen-binding sites in one molecule. bsAbs can be divided in two molecular formats; the IgG-like and non-IgG like. The structural elements of each for
Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses
Autor:
Rebecca A. Gillespie, Peter D. Kwong, Julie E. Ledgerwood, John R. Gallagher, Richard A. Koup, Madhu Prabhakaran, Brian E. Fisher, David R. Ambrozak, John R. Mascola, Ulrich Baxa, Masaru Kanekiyo, Barney S. Graham, Wing-Pui Kong, M. Gordon Joyce, Kathryn L Zephir, Adrian B. McDermott, Sarah F. Andrews, Hanne Andersen, Adrian Creanga, Adam K. Wheatley, Audray K. Harris, Kwanyee Leung, Ivelin S. Georgiev, Eun Sung Yang, Seyhan Boyoglu-Barnum, Yaroslav Tsybovsky, Hadi M. Yassine
Publikováno v:
Nature immunology
The present vaccine against influenza virus has the inevitable risk of antigenic discordance between the vaccine and the circulating strains, which diminishes vaccine efficacy. This necessitates new approaches that provide broader protection against
Autor:
Marcus Buggert, Johanna Tauriainen, Takuya Yamamoto, Juliet Frederiksen, Martin A Ivarsson, Jakob Michaëlsson, Ole Lund, Bo Hejdeman, Marianne Jansson, Anders Sönnerborg, Richard A Koup, Michael R Betts, Annika C Karlsson
Publikováno v:
PLoS Pathogens, Vol 10, Iss 7, p e1004251 (2014)
CD8(+) T cell exhaustion represents a major hallmark of chronic HIV infection. Two key transcription factors governing CD8(+) T cell differentiation, T-bet and Eomesodermin (Eomes), have previously been shown in mice to differentially regulate T cell
Externí odkaz:
https://doaj.org/article/1a4dc481bb2544cfb7f8d7a275822cd4
Autor:
Mary E Enama, Julie E Ledgerwood, Laura Novik, Martha C Nason, Ingelise J Gordon, LaSonji Holman, Robert T Bailer, Mario Roederer, Richard A Koup, John R Mascola, Gary J Nabel, Barney S Graham, VRC 011 Study Team
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e91366 (2014)
Phase 1 evaluation of the VRC HIV DNA and rAd5 vaccines delivered intramuscularly (i.m.) supported proceeding to a Phase 2 b efficacy study. Here we report comparison of the i.m., subcutaneous (s.c.) and intradermal (i.d.) routes of administration.Si
Externí odkaz:
https://doaj.org/article/2bd1714b908f4c17889a993bf675d1ce