Zobrazeno 91 - 100
of 119
pro vyhledávání: '"Reuben Benjamin"'
Autor:
Trevor Bentley, Bijan Boldajipour, Matthew Streetly, Cesar Sommer, Charlotte Graham, Reuben Benjamin, Agnieszka Jozwik, Katy Sanchez, Barbra Sasu, Kirsty Cuthill, Alan Dunlop, Charlotte Attwood, Ieuan Walker, Carmel Rice, Ana M Metelo
Publikováno v:
Blood. 134:1834-1834
Introduction: Autologous anti-BCMA CAR-T cells have been successfully used in clinical trials for the treatment of relapsed refractory Multiple Myeloma (rrMM), achieving high initial response rates (>80%). However, in some patients these therapeutic
Autor:
Metod Oblak, Daria Capece, Jane F. Apperley, Jason Bennett, Heather Oakervee, Ashutosh D. Wechalekar, Michael Tarbit, Angela Chambery, Richard Kaczmarski, Domenico Raimondo, Daniela Verzella, Ian H Gabriel, Annamaria Sandomenico, Magda J Al-Obaidi, Daniel D'Andrea, Gary Acton, Menotti Ruvo, James Kelly, Guido Franzoso, Holger W. Auner, Federica Begalli, Antonio Leonardi, Reuben Benjamin, Nigel Adams, Martin Kaiser, Elizabeth A. Campbell, Laura Tornatore, Selina Bannoo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::457e790fe48deb5035b4476b6a031fdb
http://hdl.handle.net/10044/1/70571
http://hdl.handle.net/10044/1/70571
Autor:
Reuben Benjamin, R. K. Patel, Zara Margarite Sayar, Jignesh P. Patel, Roopen Arya, Victoria Cornelius, Julia Czuprynska, Lara N. Roberts
Publikováno v:
Thrombosis Research. 164:S189-S190
Autor:
Mohamad Mohty, Deborah Yallop, Oana Ciocarlie, Svetlana Balandraud, Barbara De Moerloose, André Baruchel, Nicolas Boissel, Noelle V. Frey, Marcela V. Maus, Agnieszka Jozwik, Matthiew Frigault, Reuben Benjamin, Nitin Jain, Adrian Bloor, Charlotte Graham, Ludiane Gauthier, Amina Zinai, Waseem Qasim, Jeanne Pauly, Candy Bermingham, Anne Philippe, Cyril Konto, Paul Veys, Jérôme Larghero, Sylvain Fouliard, Elias J. Jabbour
Publikováno v:
Blood. 132:896-896
Background UCART19 is an allogeneic, genetically modified CAR T-cell product (anti-CD19 scFv- 41BB-CD3ζ) manufactured from healthy donor T cells, in which TRAC and CD52 genes have been knocked out to allow its administration in non-HLA matched patie
Publikováno v:
Cells, Vol 7, Iss 10, p 155 (2018)
Cells
Cells
Patient derived anti-CD19 chimeric antigen receptor-T (CAR-T) cells are a powerful tool in achieving a complete remission in a range of B-cell malignancies, most notably B-acute lymphoblastic leukaemia (B-ALL) and diffuse large B-cell lymphoma (DLBCL
Autor:
Emma C. Morris, Karl S. Peggs, Kirsty Thomson, Panagiotis D. Kottaridis, Noha Edwards, Stephanie Verfuerth, Andy C. Rawstron, Reuben Benjamin, Simon Richardson, Iftekhar Khan, Anthony H. Goldstone, Adele K. Fielding, Jagoda Sudak, Ronjon Chakraverty, Elisabeth Vandenberghe, Stephen Mackinnon
Publikováno v:
British Journal of Haematology. 160:640-648
Following reduced intensity-conditioned allogeneic stem cell transplantation (RIC allo-SCT) for chronic lymphocytic leukaemia (CLL), there is an inverse relationship between relapse and extensive chronic graft-versus-host disease (GVHD). We evaluated
Autor:
Neil Rabin, Paul Maciocia, Reuben Benjamin, Simon Cheesman, Shirley D'Sa, Faye Sharpley, Matthew Streetly, Nicola Maciocia, Rakesh Popat, Aviva Cerner, Steve Schey, Andrew Melville, Karthik Ramasamy, Ali Rismani, Matthew W Jenner, Kwee Yong
Publikováno v:
British journal of haematology. 176(6)
Myeloma patients who become refractory to immunomodulatory agents (IMiDs) and bortezomib have poor survival, with limited therapeutic options. Pomalidomide has shown improved survival and good tolerability in this patient cohort in clinical trials, b
Autor:
Victoria Potter, Alan Dunlop, Premal H. Patel, Frédéric Dubois, Charlotte Graham, Agnieszka Jozwik, Florence Binlich, Svetlana Balandraud, Reuben Benjamin, Shireen Kassam, Victoria Metaxa, Stephen Devereux, Sandra Dupouy, Piers E.M. Patten, Anne Philippe, Amina Zinai, Rose Ellard, Cyril Konto, Antonio Pagliuca, Ghulam J. Mufti, Farzin Farzaneh, Deborah Yallop, Orla Stewart
Publikováno v:
Blood. 130:887-887
Background UCART19 is a genetically modified T-cell product manufactured from non-HLA matched healthy donor cells. Lentiviral-transduced CAR T-cells express (1) an anti-CD19 CAR (anti-CD19 scFv- 41BB- CD3ζ) and (2) an RQR8 "safety switch" that is in
Autor:
Panagiotis D. Kottaridis, Lourdes Vázquez, Jorge Sierra, Srinivas Pillai, Amit C. Nathwani, Kirsty Thomson, Reuben Benjamin, Anna Sureda, Julio Delgado, Karl S. Peggs, José A. Pérez-Simón, Dolores Caballero, Rodrigo Martino, Donald Milligan, Richard Lovell, Stephen Mackinnon
Publikováno v:
Biology of Blood and Marrow Transplantation. 14(11):1288-1297
Reduced-intensity conditioning (RIC) allogeneic hematopoietic cell transplantation is increasingly considered for patients with chronic lymphocytic leukemia (CLL). To investigate the impact of in vivo T cell depletion with alemtuzumab on the incidenc
Autor:
Reuben Benjamin, Jon E. Arnason, Gertrude Gunset, Jason Plotkin, Maud Condomines, Michel Sadelain
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 6, p e0130518 (2015)
PLoS ONE, Vol 10, Iss 6, p e0130518 (2015)
Adoptive T cell therapy represents a promising treatment for cancer. Human T cells engineered to express a chimeric antigen receptor (CAR) recognize and kill tumor cells in a MHC-unrestricted manner and persist in vivo when the CAR includes a CD28 co