Zobrazeno 21 - 30
of 200
pro vyhledávání: '"Qing-qing Wu"'
Publikováno v:
Mediators of Inflammation, Vol 2019 (2019)
Andrographolide (Andr) is a major component isolated from the plant Andrographis paniculata. Inflammation, apoptosis, and impaired angiogenesis are implicated in the pathogenesis of high glucose (HG)-induced injury of vascular endotheliocytes. Our st
Externí odkaz:
https://doaj.org/article/fe830644ca464752aa9523ee71600253
Autor:
Ya-Ge Jin, Yuan Yuan, Qing-Qing Wu, Ning Zhang, Di Fan, Yan Che, Zhao-Peng Wang, Yang Xiao, Sha-Sha Wang, Qi-Zhu Tang
Publikováno v:
PPAR Research, Vol 2017 (2017)
Background. Puerarin is a kind of flavonoids and is extracted from Chinese herb Kudzu root. Puerarin is widely used as an adjuvant therapy in Chinese clinics. But little is known about its effects on regulating cardiac fibrosis. Methods. Mice were su
Externí odkaz:
https://doaj.org/article/998c2c8d21c0486489a1cd92fbc0e754
Autor:
Hui Zhao, Qing-Qing Wu, Lin-Feng Cao, Hou-Ying Qing, Cheng Zhang, Yuan-Hua Chen, Hua Wang, Rong-Ru Liu, De-Xiang Xu
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97266 (2014)
Several reports indicate that melatonin alleviates bleomycin (BLM)-induced pulmonary fibrosis in rodent animals. Nevertheless, the exact mechanism remains obscure. The present study investigated the effects of melatonin on endoplasmic reticulum (ER)
Externí odkaz:
https://doaj.org/article/d47d54a14bd84af193a5e059e070cac3
Publikováno v:
Chinese Medical Journal, Vol 128, Iss 20, Pp 2829-2830 (2015)
Externí odkaz:
https://doaj.org/article/59e1561cb220415eb441807a87eb85a1
Autor:
Jing Zong, Wei Deng, Heng Zhou, Zhou-yan Bian, Jia Dai, Yuan Yuan, Jie-yu Zhang, Rui Zhang, Yan Zhang, Qing-qing Wu, Hai-peng Guo, Hong-liang Li, Qi-zhu Tang
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53427 (2013)
PURPOSE: 3,3'-Diindolylmethane (DIM) is a natural component of cruciferous plants. It has strong antioxidant and anti-angiogenic effects and promotes the apoptosis of a variety of tumor cells. However, little is known about the critical role of DIM o
Externí odkaz:
https://doaj.org/article/c73cecad88e84155a67d8d1f5c834744
Autor:
Jia Dai, Di-Fei Shen, Zhou-Yan Bian, Heng Zhou, Hua-Wen Gan, Jing Zong, Wei Deng, Yuan Yuan, FangFang Li, Qing-Qing Wu, Lu Gao, Rui Zhang, Zhen-Guo Ma, Hong-Liang Li, Qi-Zhu Tang
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53412 (2013)
The inducible IκB kinase (IKKi/IKKε) is a recently described serine-threonine IKK-related kinase. Previous studies have reported the role of IKKi in infectious diseases and cancer. However, its role in the cardiac response to pressure overload rema
Externí odkaz:
https://doaj.org/article/b100b30cd1834cfb9cace38056e7aa51
Autor:
Chen Liu, Qi Yao, Tongtong Hu, Zhulan Cai, Qingwen Xie, Jinhua Zhao, Yuan Yuan, Jian Ni, Qing Qing Wu
Publikováno v:
Molecular Therapy - Nucleic Acids. 30:198-207
Cathepsin B (CTSB), a member of lysosomal cathepsin, is involved in cell autophagy and apoptosis. We previously reported that CTSB increased cardiomyocyte apoptosis in mice heart during pressure overload, while the role of CTSB on diabetic cardiomyop
Autor:
Qing-Qing, Wu, Qi, Yao, Tong-Tong, Hu, Ying, Wan, Qing-Wen, Xie, Jin-Hua, Zhao, Yuan, Yuan, Qi-Zhu, Tang
Publikováno v:
Acta Pharmacologica Sinica. 43:2562-2572
Tax1 banding protein 1 (Tax1bp1) was originally identified as an NF-κB regulatory protein that participated in inflammatory, antiviral and innate immune processes. Tax1bp1 also functions as an autophagy receptor that plays a role in autophagy. Our p
Publikováno v:
Open Journal System at Luminescience Press
Heart failure (HF) is the final manifestation of various cardiovascular (CV) diseases, which has caused a huge health burden. Although great progress has been made in the treatment strategy, it still cannot solve the dilemma of HF treatment. As a sod
Autor:
Hong-Jie, Qian, Yu, Wang, Meng-Qi, Zhang, Yuan-Chao, Xie, Qing-Qing, Wu, Li-Yu, Liang, Ye, Cao, Hua-Qing, Duan, Guang-Hui, Tian, Juan, Ma, Zhuo-Bing, Zhang, Ning, Li, Jing-Ying, Jia, Jing, Zhang, Haji Akber, Aisa, Jing-Shan, Shen, Chen, Yu, Hua-Liang, Jiang, Wen-Hong, Zhang, Zhen, Wang, Gang-Yi, Liu
Publikováno v:
Acta Pharmacologica Sinica. 43:3130-3138
VV116 (JT001) is an oral drug candidate of nucleoside analog against SARS-CoV-2. The purpose of the three phase I studies was to evaluate the safety, tolerability, and pharmacokinetics of single and multiple ascending oral doses of VV116 in healthy s