Zobrazeno 31 - 40
of 96
pro vyhledávání: '"Peter J Tummino"'
Autor:
Robert A. Copeland, Zhihong Lai, Tia Lewis, Kang Yan, Peter J. Tummino, Lata T. Gooljarsingh, John J. Kerrigan, Robert H. Sinnamon, Kyung O. Johanson, Christine Fernandes, Marc R. Arnone, Michael Grooms, Hong Zhang, Alastair J. King, Robert B. Kirkpatrick
Publikováno v:
Proceedings of the National Academy of Sciences. 103:7625-7630
Heat shock protein (Hsp)90 is emerging as an important therapeutic target for the treatment of cancer. Two analogues of the Hsp90 inhibitor geldanamycin are currently in clinical trials. Geldanamycin (GA) and its analogues have been reported to bind
Autor:
Glenn S. Van Aller, Peter J. Tummino, BaoChau Le, Gloria Mas, Roland S. Annan, Ryan G. Kruger, Patrick McDevitt, Nicolas Reynoird, Olena Barbash, Michael J. Huddleston, Or Gozani, Julien Sage, Shichong Liu, Benjamin A. Garcia, Robert H. Sinnamon, Anne-Flore Zmoos
Publikováno v:
Epigenetics
Epigenetics, Taylor & Francis, 2014, 7 (4), pp.340-343. ⟨10.4161/epi.19506⟩
Epigenetics, Taylor & Francis, 2014, 7 (4), pp.340-343. ⟨10.4161/epi.19506⟩
Smyd3 is a lysine methyltransferase implicated in chromatin and cancer regulation. Here we show that Smyd3 catalyzes histone H4 methylation at lysine 5 (H4K5me). This novel histone methylation mark is detected in diverse cell types and its formation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a29467a44d30ceee528cd26dfdecafa
https://hal.archives-ouvertes.fr/hal-02989821
https://hal.archives-ouvertes.fr/hal-02989821
Autor:
Larry Dick, Virendar K. Kaushik, Thomas F. Parsons, Peter J. Tummino, Susan L. Acton, Michael A. Patane, Kevin Godbout, Jin Tang, Elizabeth Baronas, Chad S Vickers, Frank Y. Hsieh, James M. Gavin, Paul Hales, Andrew J. Nichols
Publikováno v:
Journal of Biological Chemistry. 277:14838-14843
Human angiotensin-converting enzyme-related carboxypeptidase (ACE2) is a zinc metalloprotease whose closest homolog is angiotensin I-converting enzyme. To begin to elucidate the physiological role of ACE2, ACE2 was purified, and its catalytic activit
Autor:
Richard A. Alm, Mikael Berg, Bo Xu, Wei Yang, Peter J. Tummino, Daniel J Krosky, Gilles Carmel
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1594:297-306
3-Deoxy- D - manno -2-octulosonate-8-phosphate (KDO-8-P) synthase catalyzes the aldol-type condensation of phosphoenolpyruvate and D -arabinose-5-phosphate (A-5-P) to produce KDO-8-P and inorganic phosphate. All KDO-8-P synthases, as exemplified by t
Autor:
Michiel Vermeulen, Nicolas Reynoird, Julien Sage, Olena Barbash, Or Gozani, Atul J. Butte, Shichong Liu, Michael J. Huddleston, Ryan G. Kruger, Dashyant Dhanak, Purvesh Khatri, Alex W. Wilkinson, Pascal W. T. C. Jansen, Benjamin A. Garcia, Pawel K. Mazur, Peter J. Tummino, Glenn S. Van Aller
Publikováno v:
Nature
Nature, Nature Publishing Group, 2014, 510 (7504), pp.283-287. ⟨10.1038/nature13320⟩
Nature, 510, 283-7
Nature, 510, 7504, pp. 283-7
Nature, Nature Publishing Group, 2014, 510 (7504), pp.283-287. ⟨10.1038/nature13320⟩
Nature, 510, 283-7
Nature, 510, 7504, pp. 283-7
Deregulation of lysine methylation signalling has emerged as a common aetiological factor in cancer pathogenesis, with inhibitors of several histone lysine methyltransferases (KMTs) being developed as chemotherapeutics. The largely cytoplasmic KMT SM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5b53225d89fe016f3889175b6d8d1e0
https://hal.archives-ouvertes.fr/hal-02989816
https://hal.archives-ouvertes.fr/hal-02989816
Autor:
Anna K. Bassil, Binbin Liu, Valentina S. Caputo, Nigel J. Parr, Rab K. Prinjha, BaoChau Le, Trevor D. Chapman, Irene Roberts, Nicola Harker, Jason Witherington, Leanne Cutler, Niam Al-Mahdi, Anastasios Karadimitris, Antonia Rotolo, Nicholas Smithers, Ilaria Marigo, David F. Tough, Amin Rahemtulla, Maurits F. Kleijnen, Katerina Gouvedenou, Aristeidis Chaidos, Peter J. Tummino, Mohammed Suhail Chaudhry, Olena Barbash, Andrea C. Haynes
Publikováno v:
Blood. 123(5)
The bromodomain and extraterminal (BET) protein BRD2-4 inhibitors hold therapeutic promise in preclinical models of hematologic malignancies. However, translation of these data to molecules suitable for clinical development has yet to be accomplished
Autor:
Peter Doig, Trevor J. Trust, Gilles Carmel, Peter J. Tummino, Boudewijn L. M. de Jonge, Scott D. Mills, Brian Noonan, Eric D. Brown, Maria Uria-Nickelsen, Braydon C. Guild, Richard A. Alm, Gerald F. Vovis, Donald T. Moir
Publikováno v:
Microbiology and Molecular Biology Reviews. 63:675-707
SUMMARY Helicobacter pylori is a gram-negative bacteria which colonizes the gastric mucosa of humans and is implicated in a wide range of gastroduodenal diseases. This paper reviews the physiology of this bacterium as predicted from the sequenced gen
Autor:
Larry J. Markoski, Stephen J. Gracheck, Carolyn Nouhan, Peter J. Tummino, Steven VanderRoest, James Saunders, J. V. N. Vara Prasad, Krishna R. Iyer, Christopher Gajda, Fred E. Boyer, Donna Ferguson, Elizabeth A. Lunney, John M. Domagala, Bradley Dean Tait, Michael Sinz, Donald Hupe, Tod P. Holler, Susan Elizabeth Hagen, Edmund L. Ellsworth
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:2217-2222
Dihydropyran-2-one possessing a sulfamate moiety at the 4-position of the thiophenyl ring were designed to reach S 3 ′ pocket of the HIV protease. Synthetic routes for the preparation of thiotosylates possessing 3-(2- t -butyl-5-methyl-4-sulfamate)
Autor:
J. V. N. Vara Prasad, Donald Hupe, Elizabeth A. Lunney, John M. Domagala, Donna Ferguson, Greg Zeikus, Neil Graham, Peter J. Tummino, Susan Elizabeth Hagen, Caroline Nouhan, Tod P. Holler, Edmund L. Ellsworth
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:2019-2024
5,6-Dihydro-2H-pyran-2-ones are potent inhibitors of HIV-1 protease, which bind to the S1, S2, S1', and S2' pockets and have a unique binding mode with the catalytic aspartyl groups and the flap region of the enzyme. Efforts to explore 3-position het
Autor:
Peter J. Tummino, James Saunders, Stephen J. Gracheck, Bradley Dean Tait, J. V. N. Vara Prasad, Joanne I. Brodfuehrer, Christopher Andrew Gajda, Krishna R. Iyer, Tod P. Holler, Susan Elizabeth Hagen, Steven VanderRoest, Edmund L. Ellsworth, Fred E. Boyer, Carolyn Nouhan, Donna Ferguson, Larry James Markoski, Michael Sinz, Donald Hupe, Elizabeth A. Lunney, John M. Domagala
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:1481-1486
Dihydropyran-2-ones possessing amino and carboxamide functionalities on 3-SPh (2-tert-butyl, 5-methyl) ring were synthesized and evaluated for their antiviral activities. Both the enantiomers of inhibitor 15 were synthesized. The in vitro resistance