Zobrazeno 21 - 30
of 507
pro vyhledávání: '"Pedro R. Lowenstein"'
Autor:
Marianela Candolfi, Gwendalyn D. King, Kader Yagiz, James F. Curtin, Yohei Mineharu, AKM Ghulam Muhammad, David Foulad, Kurt M. Kroeger, Nick Barnett, Regis Josien, Pedro R. Lowenstein, Maria G. Castro
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 14, Iss 8, Pp 757-770 (2012)
Adenovirus-mediated delivery of the immune-stimulatory cytokine Flt3L and the conditionally cytotoxic thymidine kinase (TK) induces tumor regression and long-term survival in preclinical glioma (glioblastoma multiforme [GBM]) models. Flt3L induces ex
Externí odkaz:
https://doaj.org/article/48055997b2cf415fbca0be0e9b4482d5
Autor:
Marianela Candolfi, James F. Curtin, Kader Yagiz, Hikmat Assi, Mia K. Wibowo, Gabrielle E. Alzadeh, David Foulad, AKM G. Muhammad, Sofia Salehi, Naomi Keech, Mariana Puntel, Chunyan Liu, Nicholas R. Sanderson, Kurt M. Kroeger, Robert Dunn, Gislaine Martins, Pedro R. Lowenstein, Maria G. Castro
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 13, Iss 10, Pp 947-960 (2011)
We have demonstrated that modifying the tumor microenvironment through intratumoral administration of adenoviral vectors (Ad) encoding the conditional cytotoxic molecule, i.e., HSV1-TK and the immune-stimulatory cytokine, i.e., fms-like tyrosine kina
Externí odkaz:
https://doaj.org/article/4527ff1271c44c6f9dfe80d357ebd9d0
Autor:
Stephen V. Carney, Kaushik Banerjee, Anzar Mujeeb, Brandon Zhu, Santiago Haase, Maria L. Varela, Padma Kadiyala, Claire E. Tronrud, Ziwen Zhu, Devarshi Mukherji, Preethi Gorla, Yilun Sun, Rebecca Tagett, Felipe J. Núñez, Maowu Luo, Weibo Luo, Mats Ljungman, Yayuan Liu, Ziyun Xia, Anna Schwendeman, Tingting Qin, Maureen A. Sartor, Joseph F. Costello, Daniel P. Cahill, Pedro R. Lowenstein, Maria G. Castro
Publikováno v:
Clinical Cancer Research. 29:1763-1782
Purpose: Mutant isocitrate dehydrogenase 1 (mIDH1) alters the epigenetic regulation of chromatin, leading to a hypermethylation phenotype in adult glioma. This work focuses on identifying gene targets epigenetically dysregulated by mIDH1 to confer th
Autor:
Maria Luisa Varela, Andrea Comba, Syed M Faisal, Anna Argento, Andrea Franson, Marcus N Barissi, Sean Sachdev, Maria G Castro, Pedro R Lowenstein
Publikováno v:
Expert Opinion on Biological Therapy. 23:145-161
High-grade gliomas (HGG) are the most common malignant primary brain tumors in adults, with a median survival of ~18 months. The standard of care (SOC) is maximal safe surgical resection, and radiation therapy with concurrent and adjuvant temozolomid
Publikováno v:
Neuro-Oncology.
Autor:
Maria G. Castro, Pedro R. Lowenstein, Daniel P. Cahill, Joseph F. Costello, Maureen A. Sartor, Tingting Qin, Anna Schwendeman, Ziyun Xia, Yayuan Liu, Mats Ljungman, Weibo Luo, Maowu Luo, Felipe J. Núñez, Rebecca Tagett, Yilun Sun, Preethi Gorla, Devarshi Mukherji, Ziwen Zhu, Claire E. Tronrud, Padma Kadiyala, Maria L. Varela, Santiago Haase, Brandon Zhu, Anzar Mujeeb, Kaushik Banerjee, Stephen V. Carney
Supplementary Figures and Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31bec136e20960303ccc970834308449
https://doi.org/10.1158/1078-0432.22725171.v1
https://doi.org/10.1158/1078-0432.22725171.v1
Autor:
Maria G. Castro, Pedro R. Lowenstein, Daniel P. Cahill, Joseph F. Costello, Maureen A. Sartor, Tingting Qin, Anna Schwendeman, Ziyun Xia, Yayuan Liu, Mats Ljungman, Weibo Luo, Maowu Luo, Felipe J. Núñez, Rebecca Tagett, Yilun Sun, Preethi Gorla, Devarshi Mukherji, Ziwen Zhu, Claire E. Tronrud, Padma Kadiyala, Maria L. Varela, Santiago Haase, Brandon Zhu, Anzar Mujeeb, Kaushik Banerjee, Stephen V. Carney
Table S2. Liquid Chromatography and Mass Spectrometry Measurement of 2-hydroxyglutarate in the Conditioned Media of mIDH1 GCCs untreated, treated with vehicle (DMSO), or mIDH1 inhibitor (AGI-5198 or DS1001b)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73915f46862024d3a7fa42ac585a49a1
https://doi.org/10.1158/1078-0432.22725162
https://doi.org/10.1158/1078-0432.22725162
Autor:
Maria G. Castro, Pedro R. Lowenstein, Daniel P. Cahill, Joseph F. Costello, Maureen A. Sartor, Tingting Qin, Anna Schwendeman, Ziyun Xia, Yayuan Liu, Mats Ljungman, Weibo Luo, Maowu Luo, Felipe J. Núñez, Rebecca Tagett, Yilun Sun, Preethi Gorla, Devarshi Mukherji, Ziwen Zhu, Claire E. Tronrud, Padma Kadiyala, Maria L. Varela, Santiago Haase, Brandon Zhu, Anzar Mujeeb, Kaushik Banerjee, Stephen V. Carney
Purpose:Mutant isocitrate dehydrogenase 1 (mIDH1) alters the epigenetic regulation of chromatin, leading to a hypermethylation phenotype in adult glioma. This work focuses on identifying gene targets epigenetically dysregulated by mIDH1 to confer the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d3c3c2ce3a6c570ef17acab87c745c3
https://doi.org/10.1158/1078-0432.c.6533038
https://doi.org/10.1158/1078-0432.c.6533038
Supplementary Figure 5: Low dose Rapamycin does not enhance efficacy of Ad-Flt3L + Ad-TK/GCV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37ae65f196573b4d49acab3dbc9ff3c6
https://doi.org/10.1158/1535-7163.22499931
https://doi.org/10.1158/1535-7163.22499931
Supplementary Figure 2: Effect of Rapamycin on GL26 and RG2 cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79fe23de9a26fbd37c766eeed090ca40
https://doi.org/10.1158/1535-7163.22499940.v1
https://doi.org/10.1158/1535-7163.22499940.v1