Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Paul N. Moynagh"'
Autor:
Yuying Jiang, Chunmei Ma, Yingchao Hu, Yongbing Yang, Chanyuan Ma, Chunyan Wu, Lu Liu, Shuang Wen, Paul N. Moynagh, Bingwei Wang, Shuo Yang
Publikováno v:
Advanced Science, Vol 10, Iss 25, Pp n/a-n/a (2023)
Abstract The intestinal epithelium is the fastest renewing tissue in mammals and its regenerative process must be tightly controlled to minimize the risk of dysfunction and tumorigenesis. The orderly expression and activation of Yes‐associated prot
Externí odkaz:
https://doaj.org/article/2b2c4b0ccb1c48348c5a12a4a33bec85
Autor:
Joanna Zyzak, Małgorzata Mitkiewicz, Ewa Leszczyńska, Patryk Reniewicz, Paul N. Moynagh, Jakub Siednienko
Publikováno v:
Journal of Innate Immunity, Pp 1-12 (2019)
Innate immune response is a universal mechanism against invading pathogens. Toll-like receptors (TLRs), being part of a first line of defense, are responsible for detecting a variety of microorganisms. Among them TLR9, which is localized in endosomes
Externí odkaz:
https://doaj.org/article/61f9da2ebe734227b67a3c900ea98cda
Autor:
Megan Osbourn, Aoife M. Rodgers, Alice V. Dubois, Donna M. Small, Fiachra Humphries, Nezira Delagic, Paul N. Moynagh, Sinéad Weldon, Clifford C. Taggart, Rebecca J. Ingram
Publikováno v:
Biomolecules, Vol 12, Iss 12, p 1728 (2022)
Secretory leucoprotease inhibitor (SLPI) has multifaceted functions, including inhibition of protease activity, antimicrobial functions, and anti-inflammatory properties. In this study, we show that SLPI plays a role in controlling pulmonary Pseudomo
Externí odkaz:
https://doaj.org/article/023d7d828d3a4ccdb3f10ca8c6e624cd
Autor:
Linan Xu, Fiachra Humphries, Nezira Delagic, Bingwei Wang, Ashling Holland, Kevin S. Edgar, Jose R. Hombrebueno, Donna Beer Stolz, Ewa Oleszycka, Aoife M. Rodgers, Nadezhda Glezeva, Kenneth McDonald, Chris J. Watson, Mark T. Ledwidge, Rebecca J. Ingram, David J. Grieve, Paul N. Moynagh
Publikováno v:
JCI Insight, Vol 6, Iss 12 (2021)
Evolutionarily conserved signaling intermediate in Toll pathways (ECSIT) is a protein with roles in early development, activation of the transcription factor NF-κB, and production of mitochondrial reactive oxygen species (mROS) that facilitates clea
Externí odkaz:
https://doaj.org/article/0345bb89fc434b80b4c4d1233fd83303
Autor:
Jian Li, Chunmei Ma, Fei Long, Dongxue Yang, Xue Liu, Yingchao Hu, Chunyan Wu, Bingwei Wang, Min Wang, Yunzi Chen, Genyan Liu, Paul N. Moynagh, Jiawei Zhou, Tao Peng, Shuo Yang
Publikováno v:
iScience, Vol 16, Iss , Pp 468-484 (2019)
Summary: Although mitochondria are known to be involved in host defense against viral infection, the physiological role of mitophagy, a crucial mechanism for maintaining mitochondrial homeostasis, in antiviral immunity remains poorly defined. Here, w
Externí odkaz:
https://doaj.org/article/ffc7444355c14e339fc8ffda77250d36
Autor:
Fiachra Humphries, Ronan Bergin, Ruaidhri Jackson, Nezira Delagic, Bingwei Wang, Shuo Yang, Alice V. Dubois, Rebecca J. Ingram, Paul N. Moynagh
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
The NLRP3 inflammasome is important for inducing IL-1β and IL-18 inflammatory responses. Here the authors show, by generating and characterizing Peli2 deficient mice and immune cells, that an E3 ubiquitin ligase Pellino2 promotes inflammasome primin
Externí odkaz:
https://doaj.org/article/b58516ad7891424abe4c474bec6c5209
Autor:
Yingchao Hu, Yuying Jiang, Sheng Li, Xiaoqing Ma, Min Chen, Rui Yang, Shuang Wen, Paul N. Moynagh, Bingwei Wang, Gang Hu, Shuo Yang
Publikováno v:
Hu, Y, Jiang, Y, Li, S, Ma, X, Chen, M, Yang, R, Wen, S, Moynagh, P N, Wang, B, Hu, G & Yang, S 2022, ' The Gasdermin D N-terminal fragment acts as a negative feedback system to inhibit inflammasome-mediated activation of Caspase-1/11 ', Proceedings of the National Academy of Sciences, vol. 119, no. 45, e2210809119 . https://doi.org/10.1073/pnas.2210809119
Inflammatory pathways usually utilize negative feedback regulatory systems to prevent tissue damage arising from excessive inflammatory response. Whether such negative feedback mechanisms exist in inflammasome activation remains unknown. Gasdermin D
Autor:
Joel S. Riley, Hajrah Khawaja, Jennifer Fox, Joanna Majkut, Caitriona Holohan, Luke M Humphreys, Jennifer Ferris, Margarita Espona-Fiedler, Daniel B. Longley, Jamie Z. Roberts, Catherine A. Higgins, Paul N. Moynagh, Nyree Crawford, Emma Evergren, Simon S. McDade, Tamas Sessler
Publikováno v:
Roberts, J Z, Holohan, C, Sessler, T, Fox, J, Crawford, N, Riley, J S, Khawaja, H, Majkut, J, Evergren, E, Humphreys, L M, Ferris, J, Higgins, C, Espona-Fiedler, M, Moynagh, P, McDade, S S & Longley, D B 2020, ' The SCFSkp2 ubiquitin ligase complex modulates TRAIL-R2-induced apoptosis by regulating FLIP(L) ', Cell Death and Differentiation, vol. 27, pp. 2726–2741 . https://doi.org/10.1038/s41418-020-0539-7
TRAIL-R2 (DR5) is a clinically-relevant therapeutic target and a key target for immune effector cells. Herein, we identify a novel interaction between TRAIL-R2 and the Skp1-Cullin-1-F-box (SCF) Cullin-Ring E3 Ubiquitin Ligase complex containing Skp2
Autor:
Patryk Reniewicz, Ewa Leszczyńska, Paul N. Moynagh, Jakub Siednienko, Joanna Zyzak, Małgorzata Mitkiewicz
Publikováno v:
Journal of Innate Immunity, Pp 1-12 (2019)
J Innate Immun
J Innate Immun
Innate immune response is a universal mechanism against invading pathogens. Toll-like receptors (TLRs), being part of a first line of defense, are responsible for detecting a variety of microorganisms. Among them TLR9, which is localized in endosomes
Publikováno v:
Oleszycka, E, Rodgers, A M, Xu, L & Moynagh, P N 2021, ' Dendritic Cell-Specific Role for Pellino2 as a Mediator of TLR9 Signaling Pathway ', Journal of Immunology, vol. 207, no. 9, pp. 2325-2336 . https://doi.org/10.4049/jimmunol.2100236
The Journal of Immunology Author Choice
The Journal of Immunology Author Choice
Ubiquitination regulates immune signaling, and multiple E3 ubiquitin ligases have been studied in the context of their role in immunity. Despite this progress, the physiological roles of the Pellino E3 ubiquitin ligases, especially Pellino2, in immun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab9418ed45dfd10b059970074ea2203e
https://pure.qub.ac.uk/en/publications/1592d775-88eb-432c-8e0d-1fa41f21d8c4
https://pure.qub.ac.uk/en/publications/1592d775-88eb-432c-8e0d-1fa41f21d8c4