Zobrazeno 61 - 70
of 103
pro vyhledávání: '"Paul N. Moynagh"'
Characterisation of expression patterns and functional role of Cactin in early zebrafish development
Publikováno v:
Gene expression patterns : GEP. 10(4-5)
The immune system of teleost zebrafish (Danio rerio) shows high similarity to mammalian counterparts sharing many innate immune components including Toll-Like Receptors (TLRs), cytokines, chemokines and complement molecules. As in mammals, zebrafish
Autor:
Paul N. Moynagh
Publikováno v:
Trends in immunology. 30(1)
This review highlights the emerging roles of the Pellino family of E3 ubiquitin ligases as upstream mediators in Toll-like receptor (TLR) pathways that lead to activation of MAP kinases and transcription factors. The functional importance of the Pell
Autor:
Mark Pickering, Clare Twomey, Graham K. Sheridan, Keith J. Murphy, John J. O'Connor, Paul N. Moynagh
Publikováno v:
Learningmemory (Cold Spring Harbor, N.Y.). 14(8)
Hippocampal memory-associated synaptic plasticity is driven by a cascade of transcription and new protein synthesis. In vitro electrophysiological studies on acute hippocampal slices have elucidated much of what we know about this molecular cascade.
Publikováno v:
The Journal of biological chemistry. 282(41)
Members of the Pellino family are interleukin-1 receptor-associated kinase (IRAK)-interacting proteins that possess RING-like domains. The presence of these domains led to the suggestion that Pellino proteins are ubiquitin-protein isopeptide ligases
Autor:
Shizuo Akira, Kathy Banahan, Paul N. Moynagh, Katherine A. Fitzgerald, Nancy J. Rothwell, Douglas T. Golenbock, Masahiro Yamamoto, Luke A. J. O'Neill, Emmanuel Pinteaux, Sinead M. Miggin, Aisling Dunne, Caroline Murphy, Caroline A. Jefferies, Eva M. Palsson-McDermott
Toll-like receptors (TLRs)-2 and -4 are important proteins in innate immunity, recognizing microbial products and eliciting host defense responses. Both use the adapter proteins MyD88 and MyD88 adapter-like (Mal) to activate signaling pathways. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d13c40b31aed8b170349a1429de04a93
https://europepmc.org/articles/PMC1805564/
https://europepmc.org/articles/PMC1805564/
Autor:
Niamh C. O’Sullivan, Paul N. Moynagh, Ciaran M. Regan, Lisa Conboy, Paul A. McGettigan, Graham K. Sheridan, Mark Pickering, Keith J. Murphy, Desmond G. Higgins, John J. O'Connor
Publikováno v:
Journal of neurochemistry. 101(4)
A learning event initiates a cascade of altered gene expression leading to synaptic remodelling within the hippocampal dentate gyrus, a structure vital to memory formation. To illuminate this transcriptional program of synaptic plasticity we used mic
Pro-inflammatory cytokines are known to be elevated in several neuropathological states that are associated with learning and memory. We have previously demonstrated in our laboratory that the inhibition of long-term potentiation (LTP) in the dentate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9170e876a7ddcb5e3af737fa72771817
http://mural.maynoothuniversity.ie/7192/
http://mural.maynoothuniversity.ie/7192/
Autor:
Andrew G. Bowie, Michael Carty, Martina Schröder, Rory Goodbody, Paul N. Moynagh, Julianne Stack
Toll-like receptors discriminate between different pathogen-associated molecules and activate signaling cascades that lead to immune responses. The specificity of Toll-like receptor signaling occurs by means of adaptor proteins containing Toll-interl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b446c0653bef3dfcabf882ba1889fde
http://eprints.maynoothuniversity.ie/8130/
http://eprints.maynoothuniversity.ie/8130/
Autor:
Paul N. Moynagh, Bryan D. Griffin
Despite certain structural and biochemical similarities, differences exist in the function of the NF-kappaB (nuclear factor kappaB) inhibitory proteins IkappaBalpha (inhibitory kappaBalpha) and IkappaBbeta. The functional disparity arises in part fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::706982fb10081348f756568e4bf6b1da
http://eprints.maynoothuniversity.ie/7190/
http://eprints.maynoothuniversity.ie/7190/
Autor:
Paul N. Moynagh, Bryan D. Griffin
Nuclear factor-kappaB (NFkappaB) is an inducible transcription factor that plays a key role in regulating the expression of a wide range of immune and inflammatory response genes. The activity of NFkappaB is controlled at multiple levels, including c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::041b33ff720141b900d4f8bf27e198d3
http://eprints.maynoothuniversity.ie/7202/
http://eprints.maynoothuniversity.ie/7202/