Zobrazeno 41 - 50
of 212
pro vyhledávání: '"Paul A. Trainor"'
Autor:
Maureen A. Kane, Paul A. Trainor, Danika Bongfeldt, Stephen R. Shannon, Jianshi Yu, Amy E. Defnet, Alexander R. Moise
Publikováno v:
Methods Enzymol
Vitamin A (retinol) is an essential nutrient for embryonic development and adult homeostasis. Signaling by vitamin A is carried out by its active metabolite, retinoic acid (RA), following a two-step conversion. RA is a small, lipophilic molecule that
Publikováno v:
Development
Retinoic acid (RA), a vitamin A (retinol) derivative, has pleiotropic functions during embryonic development. The synthesis of RA requires two enzymatic reactions: oxidation of retinol into retinaldehyde by alcohol dehydrogenases (ADHs) or retinol de
Autor:
Amanda J. Barlow-Anacker, Ming Fu, Ankush Gosain, Christopher Seidel, Gary L. Bowlin, Korah P. Kuruvilla, Paul A. Trainor
Publikováno v:
FASEB J
Enteric nervous system (ENS) development is governed by interactions between neural crest cells (NCC) and the extracellular matrix (ECM). Hirschsprung disease (HSCR) results from incomplete NCC migration and failure to form an appropriate ENS. Prior
Autor:
José Xavier-Neto, Weiliang Huang, Maureen A. Kane, Paul A. Trainor, Hozana A. Castillo, Alexander R. Moise, Suya Wang
Publikováno v:
Developmental Dynamics. 247:976-991
Background During the final stages of heart development the myocardium grows and becomes vascularized by means of paracrine factors and cell progenitors derived from the epicardium. There is evidence to suggest that retinoic acid (RA), a metabolite o
Autor:
Suya Wang, José Xavier-Neto, Jianshi Yu, Keely Pierzchalski, Jace W. Jones, Alexander R. Moise, Maureen A. Kane, Paul A. Trainor
Publikováno v:
The FASEB Journal. 32:3765-3781
All- trans-retinoic acid (RA), a vitamin A metabolite, is an important signaling molecule required for the proper development of the heart. The epicardium is the main source of RA in the embryonic heart, yet the cardiogenic functions of epicardial-pr
Publikováno v:
Developmental Dynamics. 247:170-184
BACKGROUND: Vertebrate spinal cord development requires Sonic Hedgehog (Shh) signaling from the floorplate and notochord, where it is thought to act in concentration dependent manner to pattern distinct cell identities along the ventral-to-dorsal axi
Autor:
Jennifer L. Fish, Craig Albertson, Matthew P. Harris, Scott Lozanoff, Ralph S. Marcucio, Joan T. Richtsmeier, Paul A. Trainor
Publikováno v:
American Journal of Medical Genetics Part A. 173:985-1006
Publikováno v:
Human Molecular Genetics
Craniofacial development is a complex process that involves sequential growth and fusion of the facial prominences. When these processes fail, congenital craniofacial anomalies can occur. For example, choanal atresia (CA) is a congenital craniofacial
Autor:
Kazushi Aoto, Nobuaki Yoshida, Naoyuki Miura, Paul A. Trainor, Mohammad Khaja Mafij Uddin, Hirotomo Saitsu, Tsutomu Kume, Sachiko Iseki, Mohammod Johirul Islam, Mohammed Badrul Amin
Publikováno v:
Congenital Anomalies. 57:24-31
Foxc2, a member of the winged helix transcription factor family, is essential for eye, calvarial bone, cardiovascular and kidney development in mice. Nevertheless, how Foxc2-expressing cells and their descendent cells contribute to the development of
Autor:
Hiroshi Kurosaka, Masataka Kikuchi, Qi Wang, Takashi Yamashiro, Akihiro Nakaya, Paul A. Trainor
Publikováno v:
Disease Models & Mechanisms
Disease Models & Mechanisms, Vol 12, Iss 10 (2019)
Disease Models & Mechanisms, Vol 12, Iss 10 (2019)
Cleft palate (CP) is one of the most common congenital craniofacial anomalies in humans and can be caused by either single or multiple genetic and environmental factor(s). With respect to environmental factors, excessive intake of vitamin A during ea