Zobrazeno 61 - 70
of 593
pro vyhledávání: '"Norman Wolmark"'
Autor:
Julia R. White, Stewart J. Anderson, Eleanor Elizabeth Harris, Eleftherios P. Mamounas, Daniel G. Stover, Patricia A. Ganz, Reshma Jagsi, Reena S. Cecchini, Carmen Bergom, Valerie Theberge, Mahmoud El-Tamer, Richard C. Zellars, Dean Alden Shumway, Guang-Pei Chen, Thomas B. Julian, Norman Wolmark
Publikováno v:
Journal of Clinical Oncology. 40:TPS613-TPS613
TPS613 Background: Approximately 50% of newly diagnosed breast cancers are stage 1, with the majority being ER/PR-positive, HER2-negative. Genomic assays such as the Oncotype DX® have identified patients (pts) with reduced risk of distant metastasis
Autor:
John C. Krauss, Greg Yothers, Thomas J. George, James Lloyd Wade, Atrayee Basu Mallick, James J. Lee, Shannon Leigh Huggins-Puhalla, Carmen Joseph Allegra, Samuel A. Jacobs, Norman Wolmark
Publikováno v:
Journal of Clinical Oncology. 40:3569-3569
3569 Background: Most pts with mCRC have microsatellite stable (MSS) disease (95%) which is unresponsive to checkpoint inhibition. Chemotherapy activity is mediated through both cytotoxicity as well as immunological effects including reduced T-regula
Autor:
Arvind Dasari, Yan Lin, Scott Kopetz, Samuel A. Jacobs, Peter C. Lucas, Ibrahim Halil Sahin, Dustin A. Deming, Philip Agop Philip, Theodore S. Hong, Yesenia Rojas-Khalil, Norman Wolmark, Greg Yothers, Thomas J. George, Christopher Hanyoung Lieu
Publikováno v:
Journal of Clinical Oncology. 40:TPS3643-TPS3643
TPS3643 Background: Currently, there are no biomarkers validated prospectively in randomized studies for resected colon cancer (CC) to determine need for adjuvant chemotherapy (AC). However, circulating tumor DNA (ctDNA) represents a highly specific
Autor:
Caio Max Sao Pedro Rocha Lima, Greg Yothers, Samuel A. Jacobs, Hanna Kelly Sanoff, Deirdre Jill Cohen, Katherine A Guthrie, Norah Lynn Henry, Patricia A. Ganz, Scott Kopetz, Peter C. Lucas, Charles David Blanke, Theodore S. Hong, Norman Wolmark, Howard S. Hochster, Thomas J. George, Michael J. Overman
Publikováno v:
Journal of Clinical Oncology. 40:TPS3647-TPS3647
TPS3647 Background: Despite the superiority in progression-free survival (PFS) of inhibition of programmed cell death-1 (PD-1) pathway in dMMR/MSI-H as compared to chemotherapy with either anti-vascular endothelial growth factor receptor (VEGFr) or a
Autor:
Samuel A. Jacobs, Thomas J. George, Tatjana Kolevska, James Lloyd Wade, Richard Zera, Gary L Buchschacher, Tareq Al Baghdadi, Asheesh Shipstone, Daniel Lin, Greg Yothers, Katherine L. Pogue-Geile, Shannon Leigh Huggins-Puhalla, Carmen Joseph Allegra, Norman Wolmark
Publikováno v:
Journal of Clinical Oncology. 40:3564-3564
3564 Background: Patients (pts) with KRAS wild-type (WT) mCRC treated with single agent anti-EGFR therapy (tx) have improved OS compared to BSC but only a 10-15% response rate. Prior EGFR tx may upregulate HER amplification. For pts with quadruple WT
Autor:
Thomas J. George, Greg Yothers, Anuradha Krishnamurthy, Saima Sharif, Caio Max Sao Pedro Rocha Lima, Howard S. Hochster, Jesus C. Fabregas, Alok A. Khorana, Martin Gutierrez, Moses S. Raj, Ana Acuna Villaorduna, Carmen Joseph Allegra, Samuel A. Jacobs, Alexey Aleshin, Stacie Ittershagen, Shannon Leigh Huggins-Puhalla, Norman Wolmark
Publikováno v:
Journal of Clinical Oncology. 40:TPS3642-TPS3642
TPS3642 Background: Detection of circulating tumor DNA (ctDNA) in patients (pts) following surgery is indicative of presence of minimal/molecular residual disease (MRD) and confers a near-certain risk of disease recurrence. Therapeutic strategies to
Autor:
Mohamed E. Salem, Shannon Leigh Huggins-Puhalla, Thomas J. George, Carmen Joseph Allegra, Melanie R. Palomares, Frederick L Baehner, Norman Wolmark
Publikováno v:
Journal of Clinical Oncology. 40:TPS3632-TPS3632
TPS3632 Background: Patients (pts) with stage II and III colon cancer (CC) have unique post-operative decisions regarding adjuvant chemotherapy (ACT). There is a subset of stage II pts with defined clinicopathologic features associated with poor prog
Autor:
Thomas E. Lad, Luis Baez-Diaz, Alexander H.G. Paterson, Stewart J. Anderson, Melanie Finnigan, Joël Jean Mairet, Adam Brufsky, André Robidoux, Roger R. Gomis, Louis Fehrenbacher, Norman Wolmark, Miguel Sampayo, Juan Carlos Tercero, Eleftherios P. Mamounas, Peter C. Lucas, Antonio C. Wolff, Karen M. King
Publikováno v:
JNCI Cancer Spectrum
Background The Adjuvant Zoledronic Acid (ZA) study in early breast cancer (AZURE) showed correlation between a non-amplified MAF gene in the primary tumor and benefit from adjuvant zoledronic acid (ZA). Adverse ZA outcomes occurred in MAF-amplified p
Autor:
Eric Van Cutsem, Axel Grothey, Aimery de Gramont, Hans-Joachim Schmoll, Thomas J. George, Leonard B. Saltz, Julien Taieb, Greg Yothers, Jun Yin, Romain Cohen, Steven R. Alberts, Mohamed E. Salem, Norman Wolmark, Richard M. Goldberg, Sara Lonardi, Qian Shi, Thierry André, Zhaohui Jin, Jesse G. Dixon, Rachel Kerr, Takayuki Yoshino
Publikováno v:
J Natl Cancer Inst
Background Disease-free survival (DFS) with a 3-year median follow-up (3-year DFS) was validated as a surrogate for overall survival (OS) with a 5-year median follow-up (5-year OS) in adjuvant chemotherapy colon cancer (CC) trials. Recent data show f
Autor:
Melody A. Cobleigh, Stewart J. Anderson, Norman Wolmark, Douglas W. Arthur, Allison Zibelli, J. Lyons, Marianne K. Melnik, Melissa S. Dillmon, Matthew L. Hill, David S. Parda, Eleftherios P. Mamounas, Thomas B. Julian, Samantha A. Seaward, Dennis L. Carter, V.S. Kavadi, Lavanya Tiriveedhi, Gustav Magrinat, Sushil Beriwal, Rachel Rabinovitch, Kalliopi P. Siziopikou
Publikováno v:
J Clin Oncol
PURPOSE Preclinical studies report that trastuzumab (T) can boost radiotherapy (RT) effectiveness. The primary aim of the B-43 trial was to assess the efficacy of RT alone vs concurrent RT plus T in preventing recurrence of ipsilateral breast cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff244299bf20a477f0d82018364ef159
https://europepmc.org/articles/PMC8462554/
https://europepmc.org/articles/PMC8462554/