Zobrazeno 21 - 30
of 47
pro vyhledávání: '"Norman Sachs"'
Autor:
Alexandra Duarte, Alexandra A. Duarte, Ewa Gogola, Norman Sachs, Marco Barazas, Stefano Annunziato, Julian R. de Ruiter, Arno Velds, Sohvi Blatter, Julia M. Houthuijzen, Marieke van de Ven, Hans Clevers, Piet Borst, Jos Jonkers, Sven Rottenberg
Publikováno v:
Protocol Exchange.
Autor:
Dasja Pajkrt, Sylvie M. Koekkoek, Hans Clevers, Norman Sachs, Gerrit Koen, Katja C. Wolthers, Sabine M. G. van der Sanden
Publikováno v:
Emerging Microbes & Infections
Emerging Microbes & Infections, 7(1). Nature Publishing Group
Emerging Microbes and Infections, 7(1). Nature Publishing Group
Emerging microbes and infections, 7(1):00772. Nature Publishing Group
Emerging Microbes & Infections, 7(1). Nature Publishing Group
Emerging Microbes and Infections, 7(1). Nature Publishing Group
Emerging microbes and infections, 7(1):00772. Nature Publishing Group
Human enteroviruses frequently cause severe diseases in children. Human enteroviruses are transmitted via the fecal-oral route and respiratory droplets, and primary replication occurs in the gastro-intestinal and respiratory tracts; however, how ente
Autor:
Gerald Schwank, Arjan Buijs, René M. Overmeer, Norman Sachs, Hugo J. Snippert, Cheryl Zimberlin, Ruben van Boxtel, Harry Begthel, Jeroen Korving, Richard H. van Jaarsveld, Marc van de Wetering, Hans Clevers, Jarno Drost, Meike Logtenberg, Jan Paul Medema, Geert J. P. L. Kops, Edwin Cuppen, G. Johan A. Offerhaus, Bas Ponsioen
Publikováno v:
Nature, 521(7550), 43-37. Nature Publishing Group
Nature, 521(7550), 43-7. Nature Publishing Group
Nature, 521(7550), 43. Nature Publishing Group
Nature, 521(7550), 43-7. Nature Publishing Group
Nature, 521(7550), 43. Nature Publishing Group
Crypt stem cells represent the cells of origin for intestinal neoplasia. Both mouse and human intestinal stem cells can be cultured in medium containing the stem-cell-niche factors WNT, R-spondin, epidermal growth factor (EGF) and noggin over long ti
Autor:
Charles L. Sawyers, Norman Sachs, Ruben van Boxtel, Jarno Drost, Catherine Dowling, Harry Begthel, Phillip J. Iaquinta, Ana Gracanin, Robert G.J. Vries, Edwin Cuppen, Hans Clevers, Yu Chen, Dong Gao, Wouter R. Karthaus, John Wongvipat
Publikováno v:
Cell, 159(1), 163-75. Elsevier B.V.
SummaryThe prostate gland consists of basal and luminal cells arranged as pseudostratified epithelium. In tissue recombination models, only basal cells reconstitute a complete prostate gland, yet murine lineage-tracing experiments show that luminal c
Autor:
Inha, Heo, Devanjali, Dutta, Deborah A, Schaefer, Nino, Iakobachvili, Benedetta, Artegiani, Norman, Sachs, Kim E, Boonekamp, Gregory, Bowden, Antoni P A, Hendrickx, Robert J L, Willems, Peter J, Peters, Michael W, Riggs, Roberta, O'Connor, Hans, Clevers
Publikováno v:
Nature microbiology. 3(7)
Stem-cell-derived organoids recapitulate in vivo physiology of their original tissues, representing valuable systems to model medical disorders such as infectious diseases. Cryptosporidium, a protozoan parasite, is a leading cause of diarrhoea and a
Autor:
Hans Clevers, Norman Sachs
Publikováno v:
Current Opinion in Genetics & Development, 24, 68-73. Elsevier B.V.
Preclinical models of cancer are essential for a basic understanding of cancer biology and its translation into efficient treatment options for affected patients. Cancer cell lines and xenografts derived directly from primary human tumors have proven
Publikováno v:
The Journal of investigative dermatology
Altered expression of the tetraspanin CD151 is associated with skin tumorigenesis; however, whether CD151 is causally involved in the tumorigenic process is not known. To evaluate its role in tumor formation, we subjected epidermis-specific Cd151 kno
Autor:
Paloma Ordóñez-Morán, Maiia E. Bragina, Norman Sachs, Sonja Giger, Matthias P. Lutolf, Hans Clevers, Andrea Manfrin, Nikolce Gjorevski
Publikováno v:
Nature, 539(7630), 560-564. Nature Publishing Group
Epithelial organoids recapitulate multiple aspects of real organs, making them promising models of organ development, function and disease. However, the full potential of organoids in research and therapy has remained unrealized, owing to the poorly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6fb5241bd8bbd61fcf2b6a591960b75
https://dspace.library.uu.nl/handle/1874/350458
https://dspace.library.uu.nl/handle/1874/350458
Autor:
Sander Kelderman, Daphne L. van der Velden, John B. A. G. Haanen, Joris van de Haar, Egbert F. Smit, Nienke van Rooij, Annekatrien Depla, Sovann Kaing, Myriam Chalabi, Lorenzo F. Fanchi, Hans Clevers, Norman Sachs, Monika C. Wolkers, Emile E. Voest, Krijn K. Dijkstra, Monique E. van Leerdam, Maarten Slagter, Ton N. Schumacher, Fleur Weeber, Petur Snaebjornsson, Chiara M Cattaneo, Koen J. Hartemink, Kim Monkhorst, Rosa de Groot
Publikováno v:
Dijkstra, K K, Cattaneo, C M, Weeber, F, Chalabi, M, van de Haar, J, Fanchi, L F, Slagter, M, van der Velden, D L, Kaing, S, Kelderman, S, van Rooij, N, van Leerdam, M E, Depla, A, Smit, E F, Hartemink, K J, de Groot, R, Wolkers, M C, Sachs, N, Snaebjornsson, P, Monkhorst, K, Haanen, J, Clevers, H, Schumacher, T N & Voest, E E 2018, ' Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids ', Cell, vol. 174, no. 6, pp. 1586-1598.e12 . https://doi.org/10.1016/j.cell.2018.07.009
Cell, 174(6), 1586-1598.e12. Cell Press
Cell, 174(6), 1586-1598.e12. Elsevier B.V.
Cell
Cell, 174(6), 1586. Cell Press
Cell, 174(6), 1586-1598.e12. Cell Press
Cell, 174(6), 1586-1598.e12. Elsevier B.V.
Cell
Cell, 174(6), 1586. Cell Press
Cancer immunotherapies have shown substantial clinical activity for a subset of patients with epithelial cancers. Still, technological platforms to study cancer T-cell interactions for individual patients and understand determinants of responsiveness
Publikováno v:
Proceedings of the National Academy of Sciences. 109:21468-21473
Progression through the various stages of skin tumorigenesis is correlated with an altered expression of the integrin α3β1, suggesting that it plays an important role in the tumorigenic process. Using epidermis-specific Itga3 KO mice subjected to t