Zobrazeno 11 - 20
of 336
pro vyhledávání: '"Nir Friedman"'
Autor:
Jinghua Lu, François Van Laethem, Abhisek Bhattacharya, Marco Craveiro, Ingrid Saba, Jonathan Chu, Nicholas C. Love, Anastasia Tikhonova, Sergei Radaev, Xiaoping Sun, Annette Ko, Tomer Arnon, Eric Shifrut, Nir Friedman, Nan-Ping Weng, Alfred Singer, Peter D. Sun
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
For T cells, functional antigen receptors are selected in the thymus from a pre-selection repertoire by interaction with self MHCs. Here the authors show that specific, non-germline coded features located in the complementarity determining region 3 o
Externí odkaz:
https://doaj.org/article/2135b8948a994dbda344f75d21b684fb
Autor:
Jenia Gutin, Ronen Sadeh, Nitzan Bodenheimer, Daphna Joseph-Strauss, Avital Klein-Brill, Adi Alajem, Oren Ram, Nir Friedman
Publikováno v:
Cell Reports, Vol 22, Iss 10, Pp 2797-2807 (2018)
Summary: Transcription factor (TF) binding to DNA is crucial for transcriptional regulation. There are multiple methods for mapping such binding. These methods balance between input requirements, spatial resolution, and compatibility with high-throug
Externí odkaz:
https://doaj.org/article/d8f8baa4f4f64a3a895cab4ae35da467
Publikováno v:
Molecular Systems Biology, Vol 15, Iss 8, Pp n/a-n/a (2019)
Abstract Cells respond to environmental fluctuations by regulating multiple transcriptional programs. This response can be studied by measuring the effect of environmental changes on the transcriptome or the proteome of the cell at the end of the res
Externí odkaz:
https://doaj.org/article/aed9b2491dd94030a1b4d1b95b0b7d76
Publikováno v:
Frontiers in Human Neuroscience, Vol 13 (2019)
Measuring and assessing the cognitive load associated with different tasks is crucial for many applications, from the design of instructional materials to monitoring the mental well-being of aircraft pilots. The goal of this paper is to utilize EEG t
Externí odkaz:
https://doaj.org/article/cd3997da32f441d59beb996c08c64336
Autor:
Leticia De Mattos-Arruda, Stephen-John Sammut, Edith M. Ross, Rachael Bashford-Rogers, Erez Greenstein, Havell Markus, Sandro Morganella, Yvonne Teng, Yosef Maruvka, Bernard Pereira, Oscar M. Rueda, Suet-Feung Chin, Tania Contente-Cuomo, Regina Mayor, Alexandra Arias, H. Raza Ali, Wei Cope, Daniel Tiezzi, Aliakbar Dariush, Tauanne Dias Amarante, Dan Reshef, Nikaoly Ciriaco, Elena Martinez-Saez, Vicente Peg, Santiago Ramon y Cajal, Javier Cortes, George Vassiliou, Gad Getz, Serena Nik-Zainal, Muhammed Murtaza, Nir Friedman, Florian Markowetz, Joan Seoane, Carlos Caldas
Publikováno v:
Cell Reports, Vol 27, Iss 9, Pp 2690-2708.e10 (2019)
Summary: The detailed molecular characterization of lethal cancers is a prerequisite to understanding resistance to therapy and escape from cancer immunoediting. We performed extensive multi-platform profiling of multi-regional metastases in autopsie
Externí odkaz:
https://doaj.org/article/caa33a84a1a642cdaf3f8314c1e4dd94
Autor:
Mayuri Rege, Vidya Subramanian, Chenchen Zhu, Tsung-Han S. Hsieh, Assaf Weiner, Nir Friedman, Sandra Clauder-Münster, Lars M. Steinmetz, Oliver J. Rando, Laurie A. Boyer, Craig L. Peterson
Publikováno v:
Cell Reports, Vol 13, Iss 8, Pp 1610-1622 (2015)
The histone variant H2A.Z is a hallmark of nucleosomes flanking promoters of protein-coding genes and is often found in nucleosomes that carry lysine 56-acetylated histone H3 (H3-K56Ac), a mark that promotes replication-independent nucleosome turnove
Externí odkaz:
https://doaj.org/article/41f1b37b887c4f1e803994f1032412ff
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Adoptive immunotherapy is based on ex vivo expansion and stimulation of T-cells, followed by their transfer into patients. The need for the ex vivo culturing step provides opportunities for modulating the properties of transferred T-cells, enhancing
Externí odkaz:
https://doaj.org/article/3153ed5c36eb4209b189ecd52b771fc1
Autor:
Meytal Radzinski, Rosi Fassler, Ohad Yogev, William Breuer, Nadav Shai, Jenia Gutin, Sidra Ilyas, Yifat Geffen, Sabina Tsytkin-Kirschenzweig, Yaakov Nahmias, Tommer Ravid, Nir Friedman, Maya Schuldiner, Dana Reichmann
Publikováno v:
eLife, Vol 7 (2018)
Cellular redox status affects diverse cellular functions, including proliferation, protein homeostasis, and aging. Thus, individual differences in redox status can give rise to distinct sub-populations even among cells with identical genetic backgrou
Externí odkaz:
https://doaj.org/article/d0840b033b04419592b96828f318e0ba
Autor:
Dina Schneidman-Duhovny, Natalia Khuri, Guang Qiang Dong, Michael B Winter, Eric Shifrut, Nir Friedman, Charles S Craik, Kathleen P Pratt, Pedro Paz, Fred Aswad, Andrej Sali
Publikováno v:
PLoS ONE, Vol 13, Iss 11, p e0206654 (2018)
Accurate predictions of T-cell epitopes would be useful for designing vaccines, immunotherapies for cancer and autoimmune diseases, and improved protein therapies. The humoral immune response involves uptake of antigens by antigen presenting cells (A
Externí odkaz:
https://doaj.org/article/7669ab41e79446a5a678b9627ae1f550
Autor:
Yuichi Ichikawa, Caitlin F Connelly, Alon Appleboim, Thomas CR Miller, Hadas Jacobi, Nebiyu A Abshiru, Hsin-Jung Chou, Yuanyuan Chen, Upasna Sharma, Yupeng Zheng, Paul M Thomas, Hsuiyi V Chen, Vineeta Bajaj, Christoph W Müller, Neil L Kelleher, Nir Friedman, Daniel NA Bolon, Oliver J Rando, Paul D Kaufman
Publikováno v:
eLife, Vol 6 (2017)
The repeating subunit of chromatin, the nucleosome, includes two copies of each of the four core histones, and several recent studies have reported that asymmetrically-modified nucleosomes occur at regulatory elements in vivo. To probe the mechanisms
Externí odkaz:
https://doaj.org/article/24b6ece5ed4441b78cfba5f0e8e8b723