Zobrazeno 81 - 90
of 122
pro vyhledávání: '"Neil Maclean"'
Autor:
Rose Hurren, Yanina Eberhard, Aaron D. Schimmer, Jeffrey L. Wrana, Alessandro Datti, Marcela Gronda, Troy Ketela, Jason Moffat, Neil MacLean
Publikováno v:
Oncotarget
Scopus-Elsevier
Scopus-Elsevier
Evasion of death receptor ligand-induced apoptosis contributs to cancer development and progression. To better understand mechanisms conferring resistance to death ligands, we screened an siRNA library to identify sequences that sensitize resistant c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c98cee1d757616ab2d66b78129b3220
http://hdl.handle.net/11391/259089
http://hdl.handle.net/11391/259089
Autor:
Jalaj Arora, Kirk McCallum, Bill Hung, Methvin Isaac, Neil MacLean, Kathleen Da Silva, Abdelmalik Slassi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:1371-1373
A novel series of 5,5-diaryl-2-amino-4-pentenoates was synthesized and found to be potent and selective glycine transporter type-2 reuptake inhibitors.
Autor:
Kathleen Da Silva, Neil MacLean, Jalaj Arora, Bill Hung, Abdelmalik Slassi, Kirk McCallum, Methvin Isaac
Publikováno v:
ChemInform. 32
A novel series of 5,5-diaryl-2-amino-4-pentenoates was synthesized and found to be potent and selective glycine transporter type-2 reuptake inhibitors.
Autor:
Anne O'Brien, Julie Wilson, Ashok Tehim, David St-Martin, Abdelmalik Slassi, Lidia Demchyshyn, Angela Naismith, Methvin B. Issac, Tao Xin, Neil MacLean
Publikováno v:
ChemInform. 33
Autor:
Xiaoming Li, Marko Skrtic, Reza Beheshti Zavareh, Sirano Dhe-Paganon, Tabitha E. Wood, John C. Reed, Marcela Gronda, Derek Wong, Neil MacLean, Rose Hurren, Xinliang Mao, Troy Ketela, Jason Moffat, Meenakshi Venkatesan, David R. Rose, G. Wei Xu, Xiaoming Wang, Robert A. Batey, Mohsin Ali, Aaron D. Schimmer
The proteasomal pathway of protein degradation involves 2 discrete steps: ubiquitination and degradation. Here, we evaluated the effects of inhibiting the ubiquitination pathway at the level of the ubiquitin-activating enzyme UBA1 (E1). By immunoblot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::167fe70a4f879e46c72969abe6914960
https://europepmc.org/articles/PMC2920204/
https://europepmc.org/articles/PMC2920204/
Autor:
Tabitha E. Wood, Troy Ketela, Yanina Eberhard, Shadi Dalili, Rose Hurren, Xinliang Mao, Craig D. Simpson, John C. Reed, Jason Moffat, Robert A. Batey, Fernando Jose Suarez Saiz, Marcela Gronda, Aaron D. Schimmer, Kika Anyiwe, Mahadeo A. Sukhai, Mark D. Minden, Neil MacLean
Publikováno v:
Molecular cancer therapeutics. 9(1)
Evasion of death receptor ligand–induced apoptosis represents an important contributor to cancer development and progression. Therefore, molecules that restore sensitivity to death receptor stimuli would be important tools to better understand this
Autor:
Anne O'Brien, Rajender Kamboj, Cora Chen, David H. Lee, Charles Q. Meng, Tao Xin, Donna Hynd, Abdelmalik Slassi, Neil MacLean, Hong Wang, Louise Edwards, Caroline Seto, Suman Rakhit
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:1707-1709
A series of 5-alkyltryptamines (6) and the corresponding conformationally constrained analogues (8) have been synthesized. The structure activity relationships (SAR) at the 5-position of the indole skeleton and the ethylamine side chain have been stu
Autor:
Kirk McCallum, Tao Xin, Methvin Isaac, Neil MacLean, Lidia Demchyshyn, Julie Wilson, Abdelmalik Slassi, Hong Wang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:1719-1721
A novel series of 6-bicyclopiperazinyl-1-arylsulfonylindoles and 6-bicyclopiperidinyl-1-arylsulfonylindoles derivatives was synthesized and found to be potent and selective 5-HT6 receptor antagonists.
Autor:
Neil Maclean
Publikováno v:
Oceania. 61:156-176
Continuities and variation between the Tukumenga and other Maring clan-clusters form the problem of this paper. Until the establishment of colonial control, clan-clusters were in a continual process of dissolution and reconfiguration through warfare
Autor:
Feng-Hsu Lin, Aaron D. Schimmer, Mark D. Minden, Malik Slassi, Jeff Wrana, Dwayne L. Barber, Neil MacLean, Marcela Gronda, Lianne E Rotin, Michael F. Moran, Alessandro Datti
Publikováno v:
Blood. 124:2226-2226
Ibrutinib is a small-molecule Bruton’s tyrosine kinase (BTK) inhibitor yielding impressive clinical responses in B-cell malignancies, where BTK contributes to disease development and progression. We noted that BTK is expressed and constitutively ac