Zobrazeno 101 - 110
of 122
pro vyhledávání: '"Neil Maclean"'
Autor:
Lidia Demchyshyn, Jason E. Savage, Mase Lee, Malgorzata Dukat, Abdelmalik Slassi, Sandy Hufesein, Neil MacLean, Richard A. Glennon, Bryan L. Roth, Yuching Tsai
Publikováno v:
Bioorganicmedicinal chemistry letters. 10(20)
N-Benzenesulfonyl-5-methoxy-N,N-dimethyltryptamine (BS/5-OMe DMT; 5) was shown to bind at human 5-HT6 serotonin receptors with high affinity (Ki = 2.3 nM) relative to serotonin (Ki = 78 nM). Structural variation failed to result in significantly enha
Autor:
Louise Edwards, Lidia Demchyshyn, Neil MacLean, David H. Lee, Donna Bueschkens, Rajender Kamboj, Abdelmalik Slassi, Kirk McCallum, Methvin Isaac, Ines De Lannoy, Anne O'Brien
Publikováno v:
Bioorganicmedicinal chemistry letters. 10(9)
A series of pyrrolo[3,2,1-ij]quinoline derivatives was synthesized, evaluated for their activity against the 5-HT2c and 5-HT2a, receptors and found to be agonists at 5-HT2c with selectivity over 5-HT2a.
Autor:
Ian M. Rogers, Mark D. Minden, Timothy E Chung, John E. Dick, Shrivani Sriskanthadevan, Linda Z. Penn, Neil MacLean, Marcela Gronda, Peter J. Mullen, Feng-Hsu Lin, Mahadeo A. Sukhai, Rose Hurren, Yulia Jitkova, Stephanie Z. Xie, Aaron D. Schimmer, Bozhena Jhas, Marko Skrtic, Rob C. Laister, Xiaoming Wang
Publikováno v:
Blood. 120:2581-2581
Abstract 2581 Oxidative metabolism generates intracellular energy and metabolic intermediates necessary to promote the growth of AML cells. Recently, we demonstrated that AML cells are uniquely sensitive to inhibition of mitochondrial translation. Th
Autor:
Elisa Leung, Neil MacLean, Marcela Gronda, Methvin Isaac, Mohan Babu, Mahadeo A. Sukhai, Walid A. Houry, Aaron D. Schimmer, Zezhou Wang, Fengshu Lin, Rose Hurren, Rachel Mattson, Alicia Cole
Publikováno v:
Blood. 120:3603-3603
Abstract 3603 The mammalian mitochondrial caseinolytic protease (mClpP) is a nuclear-encoded enzyme complex responsible for degrading excess proteins in the mitochondria. It is functionally similar to the proteasome complex in the cytoplasm and struc
Autor:
Jeff Wrana, Marko Skrtic, Bozhena Livak, Neil MacLean, R. Keith Humphries, Angela C. Rutledge, Alessandro Datti, Jessie M. Cameron, Yulia Jitkova, Rose Hurren, Guri Giaever, John E. Dick, Justyna Bartoszko, Jean C.Y. Wang, Shrivani Sriskanthadevan, Xiaoming Wang, Troy Ketela, Marcela Gronda, Courteney Lai, Paul A. Spagnuolo, Jason Moffat, Corey Nislow, Zezhou Wang, Connie J. Eaves, Mark D. Minden, Aaron D. Schimmer, Yanina Eberhard, Brian H. Robinson, Marinella Gebbia
Publikováno v:
Blood. 118:233-233
Abstract 233 To identify novel therapeutic strategies that can eliminate AML and AML stem cells, we screened a library of on and off-patent drugs for candidates that could reduce the viability of engineered human AML cell lines that display the stem
Autor:
Rose Hurren, Craig D. Simpson, Aaron D. Schimmer, Neil MacLean, Troy Ketela, Yanina Eberhard, Jason Moffat
Publikováno v:
Molecular Cancer Therapeutics. 10:A22-A22
Acquisition of resistance to anchorage dependant cell death, a process termed anoikis, is a requirement for cancer cell metastasis. However, the molecular determinants of anoikis resistance and sensitivity are poorly understood. To better understand
Autor:
Robert A. Batey, Tabitha E. Wood, Michael F. Moran, Rose Hurren, Paul A. Spagnuolo, Xinliang Mao, Xiaoming Wang, Alessandro Datti, Jeff Wrana, Aaron D. Schimmer, Neil MacLean, Jiefei Tong
Publikováno v:
Web of Science
Abstract 2036 Poster Board II-13 D-cyclins are universally dysregulated in multiple myeloma and frequently over-expressed in acute leukemia. To better understand the regulation of D-cyclins and the effects of targeting their expression in myeloma and
Autor:
Neil Maclean
Publikováno v:
Oceania. 70:109-110
Autor:
Neil Maclean
Publikováno v:
Oceania. 75:308-308
Autor:
Neil Maclean
Publikováno v:
Oceania. 68:227-227