Zobrazeno 21 - 30
of 56
pro vyhledávání: '"Naomi Guppy"'
Autor:
Aaron S. Mansfield, Laurel Schunselaar, Naomi Guppy, Andrew M. Fry, Anita Singh, Sam M. Janes, Joanna Działo, Aimee Parsons, Paul Baas, Laura O'Regan, Neelam Kumar, Sara Busacca, Dean A. Fennell, Michael Sheaff, Apostolos Nakas, Annabel J. Sharkey, Alan G. Dawson
Publikováno v:
Molecular Cancer Therapeutics, 20(2), 379-388. AMER ASSOC CANCER RESEARCH
Mesothelioma is a universally lethal cancer lacking effective therapy. The spindle poison vinorelbine exhibits clinical activity in the relapsed setting, and in preclinical models requires BRCA1 to initiate apoptosis. However, the mechanisms underlyi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d700c6dfa63021d5d9560151417e146
https://hdl.handle.net/1887/3276392
https://hdl.handle.net/1887/3276392
Autor:
Jyoti S. Choudhary, Lu Yu, Snezana Susnjar, Andrew Tutt, Patty Wai, Frances Daley, Natasa Medic Milijic, Rachael Natrajan, Daniela Kolarevic, Sophie Postel-Vinay, Barrie Peck, Ioanna Mavrommati, Hannah Cottom, Gareth Muirhead, Gillian Farnie, Gerard P. Quinn, Eleanor Knight, Rebecca Marlow, Richard Buus, Patrycja Gazinska, Simon S. McDade, Sunil Pancholi, Lesley-Ann Martin, Philip A. Bland, Naomi Guppy, Maggie C.U. Cheang, Sarah Maguire, Fredrik Wallberg, Amy Gibson, Paul H. Huang, Daniela Novo, Keith Brennan, Divya Kriplani, Farzana Noor, Giulia Falgari, Erle Holgersen, Eamonn Morrison, Syed Haider, Holly E. Barker, Kalnisha Naidoo, Ioannis Roxanis, Lukas Krasny
Publikováno v:
Peck, B, Bland, P, Mavrommati, I, Muirhead, G, Cottom, H, Wai, P T, Maguire, S L, Barker, H E, Morrison, E, Kriplani, D, Yu, L, Gibson, A, Falgari, G, Brennan, K, Farnie, G, Buus, R, Marlow, R, Novo, D, Knight, E, Guppy, N, Kolarevic, D, Susnjar, S, Milijic, N M, Naidoo, K, Gazinska, P, Roxanis, I, Pancholi, S, Martin, L A, Holgersen, E M, Cheang, M C U, Noor, F, Postel-Vinay, S, Quinn, G, McDade, S, Krasny, L, Huang, P, Daley, F, Wallberg, F, Choudhary, J S, Haider, S, Tutt, A N & Natrajan, R 2021, ' 3D functional genomics screens identify CREBBP as a targetable driver in aggressive triple-negative breast cancer ', Cancer Research, vol. 81, no. 4, pp. 847-859 . https://doi.org/10.1158/0008-5472.CAN-20-1822
Peck, B, Bland, P, Mavrommati, I, Muirhead, G, Cottom, H, Wai, P T, Maguire, S L, Barker, H E, Morrison, E, Kriplani, D, Yu, L, Gibson, A, Falgari, G, Brennan, K, Farnie, G, Buus, R, Marlow, R, Novo, D, Knight, E, Guppy, N, Kolarevic, D, Susnjar, S, Milijic, N M, Naidoo, K, Gazinska, P, Roxanis, I, Pancholi, S, Martin, L-A, Holgersen, E M, Cheang, M C U, Noor, F, Postel-Vinay, S, Quinn, G, McDade, S, Krasny, L, Huang, P, Daley, F, Wallberg, F, Choudhary, J S, Haider, S, Tutt, A N & Natrajan, R 2021, ' 3D Functional Genomics Screens Identify CREBBP as a Targetable Driver in Aggressive Triple-Negative Breast Cancer ', Cancer Research, vol. 81, no. 4, pp. 847-859 . https://doi.org/10.1158/0008-5472.CAN-20-1822
Cancer Res
Peck, B, Bland, P, Mavrommati, I, Muirhead, G, Cottom, H, Wai, P T, Maguire, S L, Barker, H E, Morrison, E, Kriplani, D, Yu, L, Gibson, A, Falgari, G, Brennan, K, Farnie, G, Buus, R, Marlow, R, Novo, D, Knight, E, Guppy, N, Kolarevic, D, Susnjar, S, Milijic, N M, Naidoo, K, Gazinska, P, Roxanis, I, Pancholi, S, Martin, L-A, Holgersen, E M, Cheang, M C U, Noor, F, Postel-Vinay, S, Quinn, G, McDade, S, Krasny, L, Huang, P, Daley, F, Wallberg, F, Choudhary, J S, Haider, S, Tutt, A N & Natrajan, R 2021, ' 3D Functional Genomics Screens Identify CREBBP as a Targetable Driver in Aggressive Triple-Negative Breast Cancer ', Cancer Research, vol. 81, no. 4, pp. 847-859 . https://doi.org/10.1158/0008-5472.CAN-20-1822
Cancer Res
Triple-negative breast cancers (TNBC) are resistant to standard-of-care chemotherapy and lack known targetable driver gene alterations. Identification of novel drivers could aid the discovery of new treatment strategies for this hard-to-treat patient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e592d50d40abfd2812812de9e1d658c
https://doi.org/10.1158/0008-5472.CAN-20-1822
https://doi.org/10.1158/0008-5472.CAN-20-1822
Autor:
I Bell, Manuel Rodriguez-Justo, Katherine Lau, Naomi Guppy, Siân Culley, Dahmane Oukrif, Robert Brown, Daren J. Caruana, Geraint M.H. Thomas, Riana Gaifulina
Publikováno v:
The Analyst
A simple method completely removes contaminating paraffin from samples for clinical Raman and enhanced immunohistological analysis.
Incomplete removal of paraffin and organic contaminants from tissues processed for diagnostic histology has been
Incomplete removal of paraffin and organic contaminants from tissues processed for diagnostic histology has been
Autor:
Victoria Roulstone, Patrycja Gazinska, Alan Melcher, Andrew J. Hayes, Gareth J. Inman, Gianmaria Liccardi, Kevin J. Harrington, Naomi Guppy, Emma Davies, Pascal Meier, Jasbani H.S. Dayal, Joan Kyula-Currie, Kunzah Jamal, Henry G. Smith, Tencho Tenev, Ioannis Roxanis
Publikováno v:
EMBO Molecular Medicine
EMBO Molecular Medicine, Vol 12, Iss 6, Pp n/a-n/a (2020)
EMBO Molecular Medicine, Vol 12, Iss 6, Pp n/a-n/a (2020)
Drugs that mobilise the immune system against cancer are dramatically improving care for many people. Dying cancer cells play an active role in inducing anti‐tumour immunity but not every form of death can elicit an immune response. Moreover, resis
Autor:
Cara Brodie, Danya Cheeseman, Dominique-Laurent Couturier, Sanjeev Kumar, Jason S. Carroll, Naomi Guppy, Kosuke Yusa, Evangelia K. Papachristou, Sankari Nagarajan, Jose-Enrique Gonzalez Prada, Carlos Caldas, Alejandra Bruna, Joseph Sutton, Shanade Dunn, Emily Archer Goode, Silvia-Elena Glont, Rachael Natrajan, Shalini V. Rao, Igor Chernukhin, Rasmus Siersbæk, Kamal Kishore, Chandra Sekhar Reddy Chilamakuri, Alasdair Russell
Publikováno v:
Nature Genetics
Nature genetics
Nagarajan, S, Rao, S V, Sutton, J, Cheeseman, D, Dunn, S, Papachristou, E K, Prada, J G, Couturier, D, Kumar, S, Kishore, K, Chilamakuri, C S R, Glont, S, Archer Goode, E, Brodie, C, Guppy, N, Natrajan, R, Bruna, A, Caldas, C, Russell, A, Siersbæk, R, Yusa, K, Chernukhin, I & Carroll, J S 2020, ' ARID1A influences HDAC1/BRD4 activity, intrinsic proliferative capacity and breast cancer treatment response ', Nature Genetics, vol. 52, no. 2, pp. 187-197 . https://doi.org/10.1038/s41588-019-0541-5
Nature genetics
Nagarajan, S, Rao, S V, Sutton, J, Cheeseman, D, Dunn, S, Papachristou, E K, Prada, J G, Couturier, D, Kumar, S, Kishore, K, Chilamakuri, C S R, Glont, S, Archer Goode, E, Brodie, C, Guppy, N, Natrajan, R, Bruna, A, Caldas, C, Russell, A, Siersbæk, R, Yusa, K, Chernukhin, I & Carroll, J S 2020, ' ARID1A influences HDAC1/BRD4 activity, intrinsic proliferative capacity and breast cancer treatment response ', Nature Genetics, vol. 52, no. 2, pp. 187-197 . https://doi.org/10.1038/s41588-019-0541-5
Using genome-wide clustered regularly interspaced short palindromic repeats (CRISPR) screens to understand endocrine drug resistance, we discovered ARID1A and other SWI/SNF complex components as the factors most critically required for response to tw
Autor:
Naomi Guppy, Sabari Vallath, Robert B. Good, Elizabeth K. Sage, L. Wessels, Sam M. Janes, Constantine Alifrangis, Yuki Ishii, Dean A. Fennell, Stacey Price, Annabel J. Sharkey, Howard Lightfoot, David A. Waller, Krishna K. Kolluri, S von Karstedt, David A. Tice, Syd Barthorpe, ZhengQiang Yuan, Henning Walczak, Antonella Montinaro, Magali Michaut, Alan M. Holmes, Apostolos Nakas, Sara Busacca, Steven P. Williams, Neelam Kumar, Ultan McDermott, Doraid Alrifai, Francesco Iorio, J. Le Quesne, Mathew J. Garnett
Publikováno v:
BTS/BALR/BLF Early Career Investigators awards symposium.
Introduction Malignant mesothelioma (MM) has no biomarker driven therapies in routine clinical use. We used a drug screen of molecularly characterised MM lines to identify novel genomic biomarker driven therapy. This led to the discovery of a subset
Autor:
Neelam Kumar, Elaine Borg, Elizabeth K. Sage, Krishna K. Kolluri, Naomi Guppy, Doraid Alrifai, Matthew Nankivell, Sam M. Janes, Andrew G. Nicholson, Yuki Ishii, Mary Falzon
Publikováno v:
Lung cancer (Amsterdam, Netherlands). 127
Introduction BRCA1 associated protein-1 (BAP1) is a key tumor driver in mesothelioma and a potential biomarker predicting response to several targeted therapies in clinical testing. Whether it also modulates response to cytotoxic chemotherapy is unde
Autor:
Dominique-Laurent Couturier, Jose-Enrique Gonzalez Prada, Rachael Natrajan, Carlos Caldas, Rasmus Siersbæk, Kamal Kishore, Shalini V. Rao, Igor Chernukhin, Cara Brodie, Jason S. Carroll, Silvia-Elena Glont, Alejandra Bruna, Chandra Sekhar Reddy Chilamakuri, Emily Archer Goode, Evangelia K. Papachristou, Alasdair Russell, Sankari Nagarajan, Danya Cheeseman, Naomi Guppy, Sanjeev Kumar, Kosuke Yusa, Joseph Sutton, Shanade Dunn
Publikováno v:
Nature Genetics. 52:354-354
Autor:
Jon S. Friedland, Naomi Guppy, Akif A. Khawaja, Deborah L. W. Chong, Joanna C. Porter, Sara Brilha, Catherine W.M. Ong
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Frontiers in Immunology
Frontiers in Immunology
Pulmonary tuberculosis (TB) is caused by inhalation of Mycobacterium tuberculosis, which damages the bronchial epithelial barrier to establish local infection. Matrix metalloproteinase-1 plays a crucial role in the immunopathology of TB, causing brea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2c3c949fa901f5582edcd5fd594574d
http://hdl.handle.net/10044/1/60506
http://hdl.handle.net/10044/1/60506
Autor:
Krishna Kalyan Kolluri, Constantine Alifrangis, Neelam Kumar, Yuki Ishii, Stacey Price, Magali Michaut, Steven Williams, Syd Barthorpe, Howard Lightfoot, Sara Busacca, Annabel Sharkey, Zhenqiang Yuan, Elizabeth K Sage, Sabarinath Vallath, John Le Quesne, David A Tice, Doraid Alrifai, Sylvia von Karstedt, Antonella Montinaro, Naomi Guppy, David A Waller, Apostolos Nakas, Robert Good, Alan Holmes, Henning Walczak, Dean A Fennell, Mathew Garnett, Francesco Iorio, Lodewyk Wessels, Ultan McDermott, Samuel M Janes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c624bf4747121a33cc2bc25b14d936f9
https://doi.org/10.7554/elife.30224.032
https://doi.org/10.7554/elife.30224.032