Zobrazeno 91 - 100
of 387
pro vyhledávání: '"Michael S. Lawrence"'
Autor:
Jian Jin, Fei Ji, Damayanti Chakraborty, Anqi Ma, Sweta Mishra, H. Ümit Kaniskan, Thomas L. Clarke, Ruslan I. Sadreyev, Michael S. Lawrence, Ran Tang, Capucine Van Rechem, Johnathan R. Whetstine
Publikováno v:
Cancer Discov
Acquired chromosomal DNA copy gains are a feature of many tumors; however, the mechanisms that underpin oncogene amplification are poorly understood. Recent studies have begun to uncover the importance of epigenetic states and histone lysine methyltr
Autor:
Benjamin Nicholson, Daniel A. Haber, David A. Sweetser, Shyamala Maheswaran, Min-Kyung Choo, Fei Ji, Douglas S. Micalizzi, Nicholas J. Haradhvala, Sooncheol Lee, Adam Langenbucher, Myriam Boukhali, Yasutaka Kato, David B. Sykes, Ruslan I. Sadreyev, Samuel S. Truesdell, Manuel D. Díaz-Muñoz, Roopali Gandhi, Syed I. A. Bukhari, Maria Antonietta Mazzola, Ipsita Dey-Guha, David T. Myers, Michael S. Lawrence, Dongjun Lee, Radhika Raheja, Shobha Vasudevan, Christopher Tiedje, Wilhelm Haas, Jennifer Lombardi-Story
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-23 (2020)
Genome Biology
Lee, S, Micalizzi, D, Truesdell, S S, Bukhari, S I A, Boukhali, M, Lombardi-Story, J, Kato, Y, Choo, M K, Dey-Guha, I, Ji, F, Nicholson, B T, Myers, D T, Lee, D, Mazzola, M A, Raheja, R, Langenbucher, A, Haradhvala, N J, Lawrence, M S, Gandhi, R, Tiedje, C, Diaz-Muñoz, M D, Sweetser, D A, Sadreyev, R, Sykes, D, Haas, W, Haber, D A, Maheswaran, S & Vasudevan, S 2020, ' A post-transcriptional program of chemoresistance by AU-rich elements and TTP in quiescent leukemic cells ', Genome Biology, vol. 21, no. 1, 33 . https://doi.org/10.1186/s13059-020-1936-4
Genome Biology
Lee, S, Micalizzi, D, Truesdell, S S, Bukhari, S I A, Boukhali, M, Lombardi-Story, J, Kato, Y, Choo, M K, Dey-Guha, I, Ji, F, Nicholson, B T, Myers, D T, Lee, D, Mazzola, M A, Raheja, R, Langenbucher, A, Haradhvala, N J, Lawrence, M S, Gandhi, R, Tiedje, C, Diaz-Muñoz, M D, Sweetser, D A, Sadreyev, R, Sykes, D, Haas, W, Haber, D A, Maheswaran, S & Vasudevan, S 2020, ' A post-transcriptional program of chemoresistance by AU-rich elements and TTP in quiescent leukemic cells ', Genome Biology, vol. 21, no. 1, 33 . https://doi.org/10.1186/s13059-020-1936-4
Background Quiescence (G0) is a transient, cell cycle-arrested state. By entering G0, cancer cells survive unfavorable conditions such as chemotherapy and cause relapse. While G0 cells have been studied at the transcriptome level, how post-transcript
Autor:
Carlos Fernandez-del Castillo, Teppei Yamada, Linda T. Nieman, Chittampalli Yashaswini, Shyamala Maheswaran, Rebecca L. Porter, Vishal Thapar, Daniel A. Haber, Jeffrey A. Drebin, Gabriel Golczer, David P. Ryan, Michael S. Lawrence, David T. Ting, Tomohiro Kurokawa, Cristina R. Ferrone, Kevin D. Vo, Peter J. O'Dwyer, Alessandra Hillis, Annamaria Szabolcs, Anupriya S. Kulkarni, Abhijit Chougule, Theodore S. Hong, Robert Morris, Andrew S. Liss, Hongshan Guo, Neelima K.C. Magnus, Vikram Deshpande, Azfar Neyaz, Eric Tai, Matteo Ligorio
Publikováno v:
Proceedings of the National Academy of Sciences. 116:26835-26845
Transcriptional profiling has defined pancreatic ductal adenocarcinoma (PDAC) into distinct subtypes with the majority being classical epithelial (E) or quasi-mesenchymal (QM). Despite clear differences in clinical behavior, growing evidence indicate
Autor:
Beow Y. Yeap, David T. Myers, Taronish D. Dubash, Michael S. Lawrence, Alice T. Shaw, Nicholas J. Dyson, Sarah Phat, Robert Morris, Anna F. Farago, David A. Barbie, J. Paul Marcoux, Shyamala Maheswaran, Benjamin J. Drapkin, Elizabeth Kennedy, Jun Zhong, Yin P Hung, Rebecca S. Heist, Subba R. Digumarthy, Lecia V. Sequist, Aaron N. Hata, Marina Kem, Mari Mino-Kenudson, Daniel A. Haber, Marcello Stanzione, Deepa Rangachari
Publikováno v:
Cancer Discovery. 9:1372-1387
Small-cell lung cancer (SCLC) is an aggressive malignancy in which inhibitors of PARP have modest single-agent activity. We performed a phase I/II trial of combination olaparib tablets and temozolomide (OT) in patients with previously treated SCLC. W
Autor:
Ashok S. Bhagwat, Ramin Sakhtemani, Vimukthi Senevirathne, Roger Pique-Regi, Jessica A. Stewart, Madusha L. W. Perera, Michael S. Lawrence
Publikováno v:
J Biol Chem
Activation-induced deaminase (AID) and apolipoprotein B mRNA-editing enzyme catalytic subunit (APOBEC) enzymes convert cytosines to uracils, creating signature mutations that have been used to predict sites targeted by these enzymes. Mutation-based t
Identification of dynamic changes in chromatin conformation is a fundamental task in genetics. In 2020, Galan et al.1 presented CHESS (Comparison of Hi-C Experiments using Structural Similarity), a novel computational algorithm designed for systemati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5405ba017d03fea4dd77424d67f3235
https://doi.org/10.1101/2021.09.23.459925
https://doi.org/10.1101/2021.09.23.459925
Autor:
Adam Langenbucher, Siang-Boon Koh, Hope S. Rugo, Erica L. Mayer, Lisa A. Carey, Srinivas Vinod Saladi, Lei He, Tiffany A. Traina, Steven J. Isakoff, Vered Stearns, Minetta C. Liu, Michael S. Lawrence, Sridhar Ramaswamy, Nsan Melkonjan, Andrew Schultz, Leif W. Ellisen, Kenneth N. Ross, Karina J. Matissek
Publikováno v:
Koh, S-B, Ross, K, Isakoff, S J, Melkonjan, N, He, L, Matissek, K J, Schultz, A, Mayer, E L, Traina, T A, Carey, L A, Rugo, H S, Liu, M C, Stearns, V, Langenbucher, A, Saladi, S V, Ramaswamy, S, Lawrence, M S & Ellisen, L W 2021, ' RASAL2 Confers Collateral MEK/EGFR Dependency in Chemoresistant Triple-Negative Breast Cancer ', Clinical Cancer Research, vol. 27, no. 17, pp. 4883-4897 . https://doi.org/10.1158/1078-0432.CCR-21-0714
Clin Cancer Res
Clin Cancer Res
Purpose: While chemotherapy remains the standard treatment for triple-negative breast cancer (TNBC), identifying and managing chemoresistant tumors has proven elusive. We sought to discover hallmarks and therapeutically actionable features of refract
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47d584ccaf68267da9eb08c33d1fb8ce
https://research-information.bris.ac.uk/en/publications/1e9956ee-f86f-422d-82c9-c3c9149c2fe8
https://research-information.bris.ac.uk/en/publications/1e9956ee-f86f-422d-82c9-c3c9149c2fe8
Autor:
Ioannis Sanidas, Hanjun Lee, Purva H. Rumde, Gaylor Boulay, Robert Morris, Gabriel Golczer, Marcello Stanzione, Soroush Hajizadeh, Jun Zhong, Meagan B. Ryan, Ryan B. Corcoran, Benjamin J. Drapkin, Miguel N. Rivera, Nicholas J. Dyson, Michael S. Lawrence
Publikováno v:
Molecular Cell. 82:3333-3349.e9
The interaction of RB with chromatin is key to understanding its molecular functions. Here, for first time, we identify the full spectrum of chromatin-bound RB. Rather than exclusively binding promoters, as is often described, RB targets three fundam
Autor:
Krystle A. Lang Kuhs, Michael Cullen, Mia Steinberg, Maisa Pinheiro, Sara Bass, James S. Lewis, Michael S. Lawrence, Daniel L. Faden, Maoxuan Lin, Adam Langenbucher, Meredith Yeager, Joseph Boland, Lisa Mirabello, Robert L. Ferris
Publikováno v:
Viruses, Vol 13, Iss 1666, p 1666 (2021)
Viruses
Volume 13
Issue 8
Viruses
Volume 13
Issue 8
APOBEC (apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like) is a major mutagenic source in human papillomavirus positive oropharyngeal squamous cell carcinoma (HPV+ OPSCC). Why APOBEC mutations predominate in HPV+OPSCC remains an area o
Autor:
Songfa Zhang, Chuan Yan, David G. Millar, Qiqi Yang, James M. Heather, Adam Langenbucher, Laura T. Morton, Sean Sepulveda, Eric Alpert, Lauren R. Whelton, Dominique T. Zarrella, Mei Guo, Eleanor Minogue, Michael S. Lawrence, Bo R. Rueda, David R. Spriggs, Weiguo Lu, David M. Langenau, Mark Cobbold
Publikováno v:
Cancer research. 82(5)
Antibody–peptide epitope conjugates (APEC) are a new class of modified antibody–drug conjugates that redirect T-cell viral immunity against tumor cells. APECs contain a tumor-specific protease cleavage site linked to a patient-specific viral epit