Zobrazeno 91 - 100
of 127
pro vyhledávání: '"Michael Oberst"'
Publikováno v:
Clinicalexperimental metastasis. 19(7)
Matriptase is an epithelial-derived, cell surface serine protease. This protease activates hepatocyte growth factor (HGF) and urokinase plasminogen activator (uPA), two proteins thought to be involved in the growth and motility of cancer cells, parti
Autor:
John L, Marshall, Neelesh, Bangalore, Dorraya, El-Ashry, Yair, Fuxman, Michael, Johnson, Brian, Norris, Michael, Oberst, Elizabeth, Ness, Slawomir, Wojtowicz-Praga, Pankaj, Bhargava, Naiyer, Rizvi, Said, Baidas, Michael J, Hawkins
Publikováno v:
Cancer biologytherapy. 1(4)
Bryostatin-1 is a compound known to inhibit protein kinase C expression. Clinical trials have focused on administration schedules ranging from 1 hour to 72 hour infusions. Preclinical data suggest that the down regulation of the target PKC occurs onl
Autor:
Nicklas Forsell, Anu Korosuo, Mykola Gusti, Sebastian Rüter, Petr Havlik, Michael Obersteiner
Publikováno v:
Carbon Balance and Management, Vol 14, Iss 1, Pp 1-18 (2019)
Abstract Background In 2018, the European Union (EU) adopted Regulation 2018/841, which sets the accounting rules for the land use, land use change and forestry (LULUCF) sector for the period 2021–2030. This regulation is part of the EU’s commitm
Externí odkaz:
https://doaj.org/article/90ca0f6ba1014a05982e788fd8d34b98
Publikováno v:
Frontiers in Environmental Science, Vol 9 (2021)
Growing competition for land, water and energy call for global strategies ensuring affordable food production at minimum environmental impacts. Economic modelling studies suggest trade-off relationships between environmental sustainability and food p
Externí odkaz:
https://doaj.org/article/3bfebb91a7ae4a7a89eebf2f083c8e68
Autor:
Petra Lutterbuese, Lily Cheng, Michael Oberst, Maria Amman, Steven Coats, Scott A. Hammond, Kathy Mulgrew, Laura Richman, Stacy Fuhrmann, Patrick A. Baeuerle
Publikováno v:
Cancer Research. 72:3524-3524
Colorectal cancer (CRC) cells can harbor somatic mutations with strong impact on cancer cell signaling that limit the effectiveness of both chemotherapy and targeted therapies including monoclonal antibodies and kinase inhibitors. Therefore, novel th
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-4 (2019)
Recent publications have raised concerns regarding the actual feasibility Negative Emission Technologies (NETs). Here the authors commented on the financial viability of large-scale late century NETs and suggested that expenditure peak will occur in
Externí odkaz:
https://doaj.org/article/a6a01512efd3442b935fe69f69c3859e
Autor:
Jiaqi Huang, Herren Wu, Bahija Jallal, Michael Oberst, Maria Amann, William F. Dall’ Acqua, Melissa Damschroder, Pamela Trail, Li Peng, Steven Coats, Kristen Lekstrom, Yihong Yao, Patrick A. Baeuerle, Philip Brohawn, Scott A. Hammond
Publikováno v:
Cancer Research. 70:2584-2584
MEDI-565 (MT111) is a novel bispecific single-chain antibody of the BiTE (Bi-specific T-cell engager) class that transiently links carcinoembryonic antigen (CEA) on tumor cells with human CD3 on T cells. Engagement of CD3 and CEA by MEDI-565 induces
Autor:
Dorothy C. Bennett, Jennifer Rieker, Prasun J. Mishra, Michael Oberst, Elena V. Sviderskaya, Linan Ha, Kathleen Kelly, Glenn Merlino
Publikováno v:
Cancer Research. 70:5076-5076
Cutaneous malignant melanoma is considered one of the most deadly human cancers, based upon both its penchant for metastatic spread and its typical resistance to currently available therapy. Long known to harbor oncogenic NRAS mutations, melanomas we
Autor:
Andreas Wolf, Grit Lorenczewski, Scott A. Hammond, Stacy Fuhrmann, Petra Lutterbuese, Steven Coats, Raffaele Baffa, Benno Rattel, Kathy Mulgrew, Laura Richman, Michael Oberst, Bahija Jallal, Maria Amann, Pamela Trail, Patrick A. Baeuerle
Publikováno v:
Cancer Research. 70:5625-5625
MEDI-565 (MT111) is a novel bispecific single-chain antibody of the BiTE (Bispecific T cell engager) class that transiently links carcinoembryonic antigen (CEA) on cancer cells with human CD3 on T cells. MEDI-565 specifically binds to human CEA with
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Credibility of long-term projection in quantitative models is continuously under debate and they rely on validation to prove projection accuracy. Here the authors investigated the views on the validation approaches and they show that empirical data p
Externí odkaz:
https://doaj.org/article/7cdc72172a45481998ee55c0ac4c9246