Zobrazeno 31 - 40
of 538
pro vyhledávání: '"Michael J. Welsh"'
Autor:
Ian M. Thornell, C. Cano Portillo, P. Allen, E. Stapleton, J. Ash, A. Comellas, Alejandro A. Pezzulo, Lynda S. Ostedgaard, W. Yu, Michael J. Welsh, Steven E Mather, David A. Stoltz, Joseph Zabner, David K. Meyerholz
Publikováno v:
Journal of Cystic Fibrosis. 20:S322
Autor:
Eric A. Hoffman, Daniel P. Cook, Ryan J. Adam, Linda S. Powers, Mallory R. Stroik, Peter J. Taft, Nicholas D. Gansemer, David A. Stoltz, David K. Meyerholz, Joseph Zabner, Mahmoud H. Abou Alaiwa, Mark J. Hoegger, James D. McMenimen, Michael J. Welsh, Drake C. Bouzek
Publikováno v:
Journal of Applied Physiology. 123:526-533
Mutations in the gene encoding the cystic fibrosis (CF) transmembrane conductance regulator (CFTR) anion channel cause CF. The leading cause of death in the CF population is lung disease. Increasing evidence suggests that in utero airway development
Publikováno v:
JAMA Neurology
Simmering, J E, Welsh, M J, Liu, L, Narayanan, N S & Pottegård, A 2021, ' Association of Glycolysis-Enhancing α-1 Blockers with Risk of Developing Parkinson Disease ', JAMA Neurology, vol. 78, no. 4, pp. 407-413 . https://doi.org/10.1001/jamaneurol.2020.5157
Simmering, J E, Welsh, M J, Liu, L, Narayanan, N S & Pottegård, A 2021, ' Association of Glycolysis-Enhancing α-1 Blockers with Risk of Developing Parkinson Disease ', JAMA Neurology, vol. 78, no. 4, pp. 407-413 . https://doi.org/10.1001/jamaneurol.2020.5157
Key Points Question Is use of glycolysis-enhancing drugs, such as terazosin, doxazosin, and alfuzosin, associated with decreased risk of Parkinson disease compared with use of tamsulosin, a drug prescribed for similar indications but which does not e
Autor:
Sonya L. Heltshe, S. Carter, James E. Bruce, Rachael M. Edwards, Matthew C. Radey, Michael J. Welsh, Gordon Cooke, Christopher E. Pope, Xia Wu, Pradeep K. Singh, Charles G. Gallagher, Peter Jorth, Katherine B. Hisert, Daniel J. Wolter, Frank J. Accurso, B. Grogan, Ryan J. Adam, Edward F. McKone, Seamas C. Donnelly, David A. Stoltz, Lucas R. Hoffman, Janice L. Launspach
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 195:1617-1628
Rationale: Previous work indicates that ivacaftor improves cystic fibrosis transmembrane conductance regulator (CFTR) activity and lung function in people with cystic fibrosis and G551D-CFTR mutations but does not reduce density of bacteria or marker
Autor:
Drake C. Bouzek, Mahmoud H. Abou Alaiwa, Daniel P. Cook, Connor P. Parker, David K. Meyerholz, Linda S. Powers, Nicholas M. Sawin, Nicholas D. Gansemer, David A. Stoltz, Ian M. Thornell, Thomas O. Moninger, Michael J. Welsh, Lynda S. Ostedgaard, James D. McMenimen
Publikováno v:
Proceedings of the National Academy of Sciences. 114:6842-6847
Gel-forming mucins, the primary macromolecular components of airway mucus, facilitate airway clearance by mucociliary transport. In cystic fibrosis (CF) altered mucus properties impair mucociliary transport. Airways primarily secrete two closely rela
Autor:
Michael J. Welsh, Bonnie W. Ramsey
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 195:1092-1099
Autor:
Michael J. Welsh, Carrie K. Barker, David K. Meyerholz, David A. Stoltz, Alejandro A. Pezzulo, Joseph Zabner, Jennifer A. Bartlett, Christine L. Wohlford-Lenane, Shyam Ramachandran, Paul B. McCray
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 194:845-854
Studies suggest that inappropriate responses to proinflammatory stimuli might contribute to inflammation in cystic fibrosis (CF) lungs. However, technical challenges have made it difficult to distinguish whether altered responses in CF airways are an
Autor:
Joseph Zabner, Xiaopeng Li, Christian M Brommel, R. Villacreses Rada, Annie Ehler, Steven E Mather, Michael J. Welsh, Ian M. Thornell, Lin Lu, Philip H. Karp
Publikováno v:
A108. PATHOPHYSIOLOGY IN DIFFUSE PARENCHYMAL LUNG DISEASES.
Publikováno v:
The FASEB Journal. 33
Autor:
Eric A. Hoffman, Lynda S. Ostedgaard, Anthony J. Fischer, Michael J. Welsh, Keyan Zarei, David A. Stoltz, Brieanna M Hilkin, Maria I Pino-Argumedo, Anna L Chaly, Mahmoud H. Abou Alaiwa, Nicholas D. Gansemer, Cullen R Shanrock, Patrick D Allen
Publikováno v:
JCI Insight. 4
Mucus produced by submucosal glands is a key component of respiratory mucociliary transport (MCT). When it emerges from submucosal gland ducts, mucus forms long strands on the airway surface. However, the function of those strands is uncertain. To te