Zobrazeno 61 - 70
of 198
pro vyhledávání: '"Michael J. MacDonald"'
Autor:
M. A. Kendrick, Grzegorz Sabat, Annika Tibell, L. I. Szweda, C.-G. Östenson, Michael J. MacDonald, E.-C. Langberg
Most current knowledge of pancreatic islet pathophysiology in diabetes mellitus has come from animal models. Even though islets from humans are readily available, only a few come from diabetic donors. We had the uncommon opportunity to acquire islets
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8f5946e72dd81cdd91cc2fa1b3ffda8
https://europepmc.org/articles/PMC3615212/
https://europepmc.org/articles/PMC3615212/
Publikováno v:
Diabetes. 45:1626-1630
The enzyme activities of mitochondrial glycerol phosphate dehydrogenase (mGPD) (EC 1.1.99.5) and pyruvate carboxylase (PC) (EC 6.4.1.1) have been reported to be low in the pancreatic islet of several rodent models of NIDDM. The present study was unde
Autor:
Laura J. Brown, Michael J. MacDonald
Publikováno v:
Archives of Biochemistry and Biophysics. 326:79-84
cDNAs which encode the rat testis and pancreatic islet mitochondrial glycerol phosphate dehydrogenase (mGPD) (EC 1.1.99.5), the key enzyme of the glycerol phosphate shuttle, were recently cloned and sequenced and found to contain calmodulin-like calc
Publikováno v:
Human Gene Therapy. 7:71-78
Rat myoblast primary cultures were tested as a model for proinsulin synthesis and processing and unregulated insulin delivery for insulin-dependent diabetes mellitus (IDDM) gene therapy. Three human proinsulin cDNA constructs containing genetically e
Autor:
Michael J. MacDonald
Publikováno v:
Journal of Biological Chemistry. 270:20051-20058
Previous studies indicated that in pancreatic islets the amount of glucose-derived pyruvate that enters mitochondrial metabolism via carboxylation is approximately equal to that entering via decarboxylation and that both carboxylation and decarboxyla
Publikováno v:
Journal of Biological Chemistry. 269:14363-14366
The FAD-dependent, mitochondrial glycerol-3-phosphate dehydrogenase (EC 1.1.99.5) is an essential component of the glycerol phosphate shuttle and is abundant in the pancreatic insulin cell, skeletal muscle, and brain. Although DNA clones for this enz
Autor:
Michael J. MacDonald
Publikováno v:
Rhetorica. 18:103-105
Autor:
Noaman Hasan, Michael J. MacDonald, Scott W. Stoker, Melissa J. Longacre, Laura J. Brown, Mindy A. Kendrick
Publikováno v:
The Journal of biological chemistry. 284(51)
The cytosolic malic enzyme (ME1) has been suggested to augment insulin secretion via the malate-pyruvate and/or citrate-pyruvate shuttles, through the production of NADPH or other metabolites. We used selectable vectors expressing short hairpin RNA (
Publikováno v:
Journal of Biological Chemistry. 266:22392-22397
It has been shown previously that glucose-induced insulin release is completely absent in rat pancreatic islets that had been cultured for 1 day at low glucose (1 mM) and that it is restored by culturing islets for a 2nd day at high (20 mM) glucose (
Publikováno v:
Diabetes Research and Clinical Practice. 14:75-81
Affinity chromatography provides a more specific estimate of glycosylated hemoglobin (GlyHb) than does ion exchange chromatography (HbA 1 ). However, whether GlyHb correlates closer than HbA 1 with mean blood glucose has not been established. GlyHb a