Zobrazeno 41 - 50
of 198
pro vyhledávání: '"Michael J. MacDonald"'
Autor:
Maciej T. Malecki, Sian Ellard, Donald F. Steiner, Julie Støy, Andrew Parrish, Louis H. Philipson, Graeme I. Bell, Maggie Shepherd, Ritika R. Kapoor, Sarah E. Flanagan, Chris Boustred, Michael J. MacDonald, Beverley M. Shields, Emma L. Edghill, Khalid Hussain, Andrew T. Hattersley, Ann-Marie Patch
Publikováno v:
Diabetes. 57:1034-1042
OBJECTIVE— Insulin gene (INS) mutations have recently been described as a cause of permanent neonatal diabetes (PND). We aimed to determine the prevalence, genetics, and clinical phenotype of INS mutations in large cohorts of patients with neonatal
Autor:
Michael J. MacDonald
One of the most remarkable trends in the humanities and social sciences in recent decades has been the resurgence of interest in the history, theory, and practice of rhetoric: in an age of global media networks and viral communication, rhetoric is on
Autor:
Michael J. MacDonald
Publikováno v:
Journal of Biological Chemistry. 282:6043-6052
Insulin secretion by the beta cell depends on anaplerosis in which insulin secretagogues are metabolized by mitochondria into molecules that are most likely exported to the extramitochondrial space where they have signaling roles. However, very littl
Autor:
John C. Wallace, Phatchariya Phannasil, Sarawut Jitrapakdee, Malee Warnnissorn, Michael J. MacDonald, Chanitra Thuwajit
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129848 (2015)
PLoS ONE
PLoS ONE
Pyruvate carboxylase (PC) is an anaplerotic enzyme that catalyzes the carboxylation of pyruvate to oxaloacetate, which is crucial for replenishing tricarboxylic acid cycle intermediates when they are used for biosynthetic purposes. We examined the ex
Publikováno v:
The Journal of biological chemistry. 290(17)
The lipid composition of insulin secretory granules (ISG) has never previously been thoroughly characterized. We characterized the phospholipid composition of ISG and mitochondria in pancreatic beta cells without and with glucose stimulation. The pho
Publikováno v:
Journal of Biological Chemistry. 279:27278-27285
Coenzyme Q(0) (Q(0)), a strong electrophile, is toxic to insulin-producing cells. Q(0) was incubated with rat and human pancreatic islets and INS-1 insulinoma cells, and its attachment to cellular proteins was studied with Western analysis using anti
Publikováno v:
Hormone and Metabolic Research. 45:391-393
A comparison of an enzyme’s level in pancreatic islets with its level in other body tissues can give clues about the importance of a metabolic pathway in the islets. ATP citrate lyase plays a key role in the pyruvate citrate shuttle, as well as for
Autor:
Susanne G. Straub, Yi Jia Liu, Geoffrey W. G. Sharp, Heather Drought, Haiying Cheng, Michael J. MacDonald
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 285:E380-E389
Leucine and glutamine were used to elicit biphasic insulin release in rat pancreatic islets. Leucine did not mimic the full biphasic response of glucose. Glutamine was without effect. However, the combination of the two did mimic the biphasic respons
Autor:
Michael J. MacDonald
Publikováno v:
Metabolism. 52:993-998
Recent evidence suggests that the mitochondrial synthesis (anaplerosis) of alpha-ketoglutarate or intermediates that can be converted to alpha-ketoglutarate, such as citrate or glutamate, are important for insulin secretion stimulated by metabolizabl
Autor:
Michael J. MacDonald
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1619:77-88
Combinations of insulin secretagogue-derived metabolites were added to microgram amounts of mitochondria obtained from rat and mouse pancreatic islets and the INS-1 cell line, and the export of citric acid cycle intermediates was surveyed to study an