Zobrazeno 51 - 60
of 69
pro vyhledávání: '"Matthew Trotter"'
Autor:
David W. M. Tan, Matthew Trotter, Kim B. Jensen, Simon Broad, Fiona M. Watt, John T. Connelly
Publikováno v:
Development (Cambridge, England)
Human epidermal stem cells express high levels of β1 integrins, delta-like 1 (DLL1) and the EGFR antagonist LRIG1. However, there is cell-to-cell variation in the relative abundance of DLL1 and LRIG1 mRNA transcripts. Single-cell global gene express
Autor:
Chad C. Bjorklund, Matthew Trotter, Anke Klippel, Anita Gandhi, Rajesh Chopra, Thomas O. Daniel, Michael Amatangelo, Anjan Thakurta
Publikováno v:
Blood. 126:5355-5355
Background: Immunomodulatory drugs exhibit several anti-Multiple Myeloma (MM) activities including: growth arrest, antiangiogenesis, inhibition of tumor necrosis factor-alpha signaling and induction of apoptosis. The mechanism of action of the IMiD®
Autor:
Anita Gandhi, Paola Neri, Nizar J. Bahlis, Matthew Trotter, Anjan Thakurta, Anke Klippel, Maria Ortiz, Michael Amatangelo, Rajesh Chopra, Thomas O. Daniel, Chad C. Bjorklund
Publikováno v:
Blood. 126:1789-1789
Background: Cereblon (CRBN) is a substrate receptor of the Cullin 4 E3 ubiquitin ligase complex CRL4CRBN and is the molecular target of the IMiD® immunomodulatory drug lenalidomide. It has been shown that cereblon is required for the anti-proliferat
Autor:
Reinhard Marks, Giovanni Martinelli, Patrick Hagner, Carrie Brachman, Antoine Thyss, Anjan Thakurta, Noel Milpied, Carla Heise, Anita Gandhi, Maria Ortiz-Estevez, Stephan Stilgenbauer, Matthew Trotter, Hsiling Chiu, Franck Morschhauser, James Carmichael, Tsvetan Biyukov, Pellegrino Musto, Marek Trneny, Luca Arcaini, Thomas O. Daniel, Rajesh Chopra
Publikováno v:
Blood. 126:821-821
Introduction: Lenalidomide (Len) is indicated for the treatment of relapsed/refractory (R/R) Mantle Cell Lymphoma (MCL) in the United States and Switzerland. Len binds to the cullin 4 ring E3 ubiquitin ligase complex resulting in ubiquitination and s
Autor:
Marc van de Wetering, Vivian W. Y. Wong, Richard Poulsom, Agnieszka Wabik, Kim B. Jensen, Hans Clevers, Fiona M. Watt, Matthew Trotter, Daniel E. Stange, Simon J.A. Buczacki, Mahalia E. Page, Doug J. Winton, Satoshi Itami, Nicholas A. Wright
Publikováno v:
Nature cell biology
Nature Cell Biology, 14(4), 401-408. Nature Publishing Group
Nature Cell Biology, 14(4), 401-408. Nature Publishing Group
Maintenance of adult tissues is carried out by stem cells and is sustained throughout life in a highly ordered manner. Homeostasis within the stem-cell compartment is governed by positive- and negative-feedback regulation of instructive extrinsic and
Publikováno v:
Molecular informatics. 31(3-4)
The support vector machine (SVM) methodology has become a popular and well-used component of present chemometric analysis. We assess a relatively recent development of the algorithm, multiple kernel learning (MKL), on published structure-property rel
Autor:
Sasha Mendjan, Matthew Trotter, Lucy E. Smithers, Roger A. Pedersen, Stephanie Brown, Ludovic Vallier, Peter J. Rugg-Gunn, Gabrielle Brons, Zhenzhi Chng, Amelie Martinez, Candy H.-H. Cho, Adrian Kee Keong Teo
The pluripotent status of embryonic stem cells (ESCs) confers upon them the capacity to differentiate into the three primary germ layers, ectoderm,mesoderm and endoderm, from which all the cells of the adult body are derived. An understanding of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::885a291dd3a446a3a3fdfc3951c971f2
https://europepmc.org/articles/PMC2687465/
https://europepmc.org/articles/PMC2687465/
Autor:
Sarah A. Teichmann, Berthold Göttgens, Matthew Trotter, Diego Miranda-Saavedra, Subhajyoti De
Publikováno v:
Nucleic Acids Research
Haematopoiesis is the process whereby blood stem cells give rise to at least fourteen functionally distinct mature cell types, and represents the best characterized mammalian adult stem cell system. Here we introduce the BloodExpress database, the fi
Autor:
Chris Boshoff, Matthew Trotter, Dimitra Bourboulia, Dimitrios Lagos, Yasuhiro Takeuchi, Mark Cannon, Fiona Gratrix, Richard J. Vart, Leonid L. Nikitenko
Publikováno v:
Cancer research. 67(9)
Kaposi's sarcoma (KS) is caused by Kaposi's sarcoma–associated herpesvirus (KSHV) and consists of proliferating spindle cells, which are related to lymphatic endothelial cells (LEC). Angiopoietin-2 (Ang2) is a secreted proangiogenic and lymphangiog
Autor:
Nick C. Matthews, Matthew Trotter, Chris Boshoff, Dimitrios Lagos, Ornella Flore, Amy Hansen, Hsei-Wei Wang, Richard J. Vart, Frances Gotch
Publikováno v:
Blood. 109(4)
Kaposi sarcoma–associated herpesvirus (KSHV) is etiologically linked to Kaposi sarcoma (KS), a tumor genetically akin to lymphatic endothelial cells (LECs). We obtained the immune transcriptional signature of KS and used KSHV-infected LECs (KLECs)