Zobrazeno 21 - 30
of 306
pro vyhledávání: '"Matthew R. Sydes"'
Autor:
Francesca Schiavone, Riya Bathia, Krishna Letchemanan, Lindsey Masters, Claire Amos, Anna Bara, Louise Brown, Clare Gilson, Cheryl Pugh, Nafisah Atako, Fleur Hudson, Mahesh Parmar, Ruth Langley, Richard S. Kaplan, Chris Parker, Gert Attard, Noel W. Clarke, Silke Gillessen, Nicholas D. James, Tim Maughan, Matthew R. Sydes, On behalf of past and present members of the STAMPEDE and FOCUS4 Trial Management Group
Publikováno v:
Trials, Vol 20, Iss 1, Pp 1-13 (2019)
Abstract Background There are limited research and literature on the trial management challenges encountered in running adaptive platform trials. This trial design allows both (1) the seamless addition of new research comparisons when compelling clin
Externí odkaz:
https://doaj.org/article/6e07272452b74f78bf38922ab9f8d1a4
Autor:
Carlos Diaz-Montana, William J. Cragg, Rahela Choudhury, Nicola Joffe, Matthew R. Sydes, Sally P. Stenning
Publikováno v:
Trials, Vol 20, Iss 1, Pp 1-11 (2019)
Abstract Background Triggered monitoring in clinical trials is a risk-based monitoring approach where triggers (centrally monitored, predefined key risk and performance indicators) drive the extent, timing, and frequency of monitoring visits. The TEM
Externí odkaz:
https://doaj.org/article/d71691a1a26142f6bdb186d0096e5a87
Autor:
Nurulamin M. Noor, Sarah L. Pett, Hanif Esmail, Angela M. Crook, Claire L. Vale, Matthew R. Sydes, Mahesh K.B. Parmar
Publikováno v:
F1000Research, Vol 9 (2020)
Global health pandemics, such as coronavirus disease 2019 (COVID-19), require efficient and well-conducted trials to determine effective interventions, such as treatments and vaccinations. Early work focused on rapid sequencing of severe acute respir
Externí odkaz:
https://doaj.org/article/61d8b86fa4a24a4f819a91086761b336
Autor:
Nurulamin M. Noor, Sarah L. Pett, Hanif Esmail, Angela M. Crook, Claire L. Vale, Matthew R. Sydes, Mahesh K.B. Parmar
Publikováno v:
F1000Research, Vol 9 (2020)
Global health pandemics, such as coronavirus disease 2019 (COVID-19), require efficient and well-conducted trials to determine effective interventions, such as treatments and vaccinations. Early work focused on rapid sequencing of severe acute respir
Externí odkaz:
https://doaj.org/article/22a7038099c64646b63619103441991d
Autor:
Marco Marcello, James W. Denham, Angel Kennedy, Annette Haworth, Allison Steigler, Peter B. Greer, Lois C. Holloway, Jason A. Dowling, Michael G. Jameson, Dale Roach, David J. Joseph, Sarah L. Gulliford, David P. Dearnaley, Matthew R. Sydes, Emma Hall, Martin A. Ebert
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Purpose: Dose information from organ sub-regions has been shown to be more predictive of genitourinary toxicity than whole organ dose volume histogram information. This study aimed to identify anatomically-localized regions where 3D dose is associate
Externí odkaz:
https://doaj.org/article/320ab27893814288a577a1000c3e012a
Autor:
Philip Pallmann, Alun W. Bedding, Babak Choodari-Oskooei, Munyaradzi Dimairo, Laura Flight, Lisa V. Hampson, Jane Holmes, Adrian P. Mander, Lang’o Odondi, Matthew R. Sydes, Sofía S. Villar, James M. S. Wason, Christopher J. Weir, Graham M. Wheeler, Christina Yap, Thomas Jaki
Publikováno v:
BMC Medicine, Vol 16, Iss 1, Pp 1-15 (2018)
Abstract Adaptive designs can make clinical trials more flexible by utilising results accumulating in the trial to modify the trial’s course in accordance with pre-specified rules. Trials with an adaptive design are often more efficient, informativ
Externí odkaz:
https://doaj.org/article/efc892793b0644d397320bd46ec68965
Autor:
Elizabeth J. Conroy, Barbara Arch, Nicola L. Harman, J. Athene Lane, Steff C. Lewis, John Norrie, Matthew R. Sydes, Carrol Gamble
Publikováno v:
Trials, Vol 18, Iss 1, Pp 1-14 (2017)
Abstract Background The DAMOCLES project established a widely used Data Monitoring Committee (DMC) Charter for randomised controlled trials (RCTs). Typically, within the UK, the DMC is advisory and recommends to another executive body; the Trial Stee
Externí odkaz:
https://doaj.org/article/63cb99506550487fa9b6052b3e7fd1ea
Autor:
Anne Daykin, Lucy E. Selman, Helen Cramer, Sharon McCann, Gillian W. Shorter, Matthew R. Sydes, Carrol Gamble, Rhiannon Macefield, J. Athene Lane, Alison Shaw
Publikováno v:
Trials, Vol 18, Iss 1, Pp 1-16 (2017)
Abstract Background The oversight and conduct of a randomised controlled trial involves several stakeholders, including a Trial Steering Committee (TSC), Trial Management Group (TMG), Data Monitoring Committee (DMC), funder and sponsor. We aimed to e
Externí odkaz:
https://doaj.org/article/5cfb1526bf084ccf9612bbdcae3cbfc7
Autor:
Karla Hemming, Anna Kearney, Carrol Gamble, Tianjing Li, Peter Jüni, An-Wen Chan, Matthew R. Sydes
Publikováno v:
Trials, Vol 21, Iss 1, Pp 1-2 (2020)
Externí odkaz:
https://doaj.org/article/1b6e6bef1900407cbc5105ea87cdc199
Autor:
Shaun Treweek, Peter Jüni, Tianjing Li, Jonathan Collin, Matthias Briel, An-Wen Chan, Karla Hemming, William J. Meurer, Matthew R. Sydes, Jeremy M. Grimshaw
Publikováno v:
Trials, Vol 21, Iss 1, Pp 1-2 (2020)
Externí odkaz:
https://doaj.org/article/7255e9b518734fa19cdbda4be57de538